ES8707108A1 - Hydrophilising of micronised antibiotic particles - Google Patents
Hydrophilising of micronised antibiotic particlesInfo
- Publication number
- ES8707108A1 ES8707108A1 ES556739A ES556739A ES8707108A1 ES 8707108 A1 ES8707108 A1 ES 8707108A1 ES 556739 A ES556739 A ES 556739A ES 556739 A ES556739 A ES 556739A ES 8707108 A1 ES8707108 A1 ES 8707108A1
- Authority
- ES
- Spain
- Prior art keywords
- weight
- particles
- binding agent
- parts
- surfactant
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000002245 particle Substances 0.000 title abstract 5
- 230000003115 biocidal effect Effects 0.000 title abstract 2
- 239000011230 binding agent Substances 0.000 abstract 3
- 239000004094 surface-active agent Substances 0.000 abstract 3
- 239000008187 granular material Substances 0.000 abstract 2
- 239000000126 substance Substances 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- RZVAJINKPMORJF-UHFFFAOYSA-N Acetaminophen Chemical compound CC(=O)NC1=CC=C(O)C=C1 RZVAJINKPMORJF-UHFFFAOYSA-N 0.000 abstract 1
- BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 abstract 1
- 229960001138 acetylsalicylic acid Drugs 0.000 abstract 1
- 150000001720 carbohydrates Chemical class 0.000 abstract 1
- 230000001427 coherent effect Effects 0.000 abstract 1
- 239000013078 crystal Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229960005489 paracetamol Drugs 0.000 abstract 1
- 239000000843 powder Substances 0.000 abstract 1
Landscapes
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The surface of micronized and hydrophilized powder particles of a water-resistant or not readily soluble substance is covered with a coherent layer of a maximum of 0.1 parts by weight of surfactant in a maximum of 10 parts by weight of a binding agent (relative to 100 parts by weight of the substance). Instant granulates or tablets are prepared from a not easily soluble or insoluble antibiotic, and effervescent granulates or tablets are prepared from a water-resistant pharmaceutical substance, of medium to easy solubility, such as acetylsalicylic acid or paracetamol for example. The particles will be preferably attached to carbohydrate crystals by means of a binding agent. For preparation, a solution which, relative to the weight of the particles to be lyophilized, contains at least a surfactant in an amount of 0.01 to 0.1% by weight, and a binding agent in an amount equivalent to five to ten times the weight of the surfactant used, is sucked through a loose mass of particles, at a pressure less than 800 mbar, preferably less than 100 mbar.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES556739A ES8707108A1 (en) | 1986-06-25 | 1986-06-25 | Hydrophilising of micronised antibiotic particles |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES556739A ES8707108A1 (en) | 1986-06-25 | 1986-06-25 | Hydrophilising of micronised antibiotic particles |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8707108A1 true ES8707108A1 (en) | 1987-07-16 |
| ES556739A0 ES556739A0 (en) | 1987-07-16 |
Family
ID=8491646
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES556739A Expired ES8707108A1 (en) | 1986-06-25 | 1986-06-25 | Hydrophilising of micronised antibiotic particles |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES8707108A1 (en) |
-
1986
- 1986-06-25 ES ES556739A patent/ES8707108A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ES556739A0 (en) | 1987-07-16 |
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