ES8606352A1 - Procedimiento de preparacion de derivados del pirrol - Google Patents
Procedimiento de preparacion de derivados del pirrolInfo
- Publication number
- ES8606352A1 ES8606352A1 ES550085A ES550085A ES8606352A1 ES 8606352 A1 ES8606352 A1 ES 8606352A1 ES 550085 A ES550085 A ES 550085A ES 550085 A ES550085 A ES 550085A ES 8606352 A1 ES8606352 A1 ES 8606352A1
- Authority
- ES
- Spain
- Prior art keywords
- pyrrole
- bromo
- benzoyl
- derivs
- prepn
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- KAESVJOAVNADME-UHFFFAOYSA-N Pyrrole Chemical compound C=1C=CNC=1 KAESVJOAVNADME-UHFFFAOYSA-N 0.000 title abstract 4
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 abstract 2
- SAQAERNKMHATDZ-UHFFFAOYSA-N 2-bromo-1h-pyrrole Chemical compound BrC1=CC=CN1 SAQAERNKMHATDZ-UHFFFAOYSA-N 0.000 abstract 1
- HHONATOJHSQDPZ-UHFFFAOYSA-N 3H-pyrrolizine Chemical compound C1=CN2CC=CC2=C1 HHONATOJHSQDPZ-UHFFFAOYSA-N 0.000 abstract 1
- FERIUCNNQQJTOY-UHFFFAOYSA-M Butyrate Chemical compound CCCC([O-])=O FERIUCNNQQJTOY-UHFFFAOYSA-M 0.000 abstract 1
- FERIUCNNQQJTOY-UHFFFAOYSA-N Butyric acid Natural products CCCC(O)=O FERIUCNNQQJTOY-UHFFFAOYSA-N 0.000 abstract 1
- 239000002841 Lewis acid Substances 0.000 abstract 1
- 238000007126 N-alkylation reaction Methods 0.000 abstract 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 abstract 1
- 229910021627 Tin(IV) chloride Inorganic materials 0.000 abstract 1
- 229940035676 analgesics Drugs 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 229940121363 anti-inflammatory agent Drugs 0.000 abstract 1
- PASDCCFISLVPSO-UHFFFAOYSA-N benzoyl chloride Chemical compound ClC(=O)C1=CC=CC=C1 PASDCCFISLVPSO-UHFFFAOYSA-N 0.000 abstract 1
- WTEOIRVLGSZEPR-UHFFFAOYSA-N boron trifluoride Chemical compound FB(F)F WTEOIRVLGSZEPR-UHFFFAOYSA-N 0.000 abstract 1
- XBPOBCXHALHJFP-UHFFFAOYSA-N ethyl 4-bromobutanoate Chemical compound CCOC(=O)CCCBr XBPOBCXHALHJFP-UHFFFAOYSA-N 0.000 abstract 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 abstract 1
- 230000003301 hydrolyzing effect Effects 0.000 abstract 1
- 150000007517 lewis acids Chemical class 0.000 abstract 1
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 abstract 1
- 235000015320 potassium carbonate Nutrition 0.000 abstract 1
- 229910000027 potassium carbonate Inorganic materials 0.000 abstract 1
- 239000012312 sodium hydride Substances 0.000 abstract 1
- 229910000104 sodium hydride Inorganic materials 0.000 abstract 1
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 abstract 1
- 239000011592 zinc chloride Substances 0.000 abstract 1
- 235000005074 zinc chloride Nutrition 0.000 abstract 1
- JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 abstract 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS DEL PIRROL. COMPRENDE: A) N-ALQUILAR AL 2-BROMOPIRROL CON 4-BROMOBUTIRATO DE ETILO EN PRESECIA DE CARBONATO POTASICO ANHIDRO, PARA DAR (A); B) HACER REACCIONARA (A) CON CLORURO DE BENZOILO, EN PRESENCIA DE UN ACIDO DE LEWIS COMO TRIFLUORURO DE BORO, CLORURO DE CINC Y CLORURO ESTANNICO, PARA DAR (B); C) CICLAR A (B) EN PRESENCIA DE HIDRURO SODICO Y EN DIMETILFORMAMIDA, PARA DAR (C); Y D) HIDROLIZAR EN MEDIO BASICO A (C) PARA OBTENER UN COMPUESTO DE FORMULA (I). SIENDO; A, 2-BROMO-1-PIRROL-BUTIRATO DE ETILO; B, 2-BROMO-5-BENZOIL-1-PIRROLBUTIRATO DE ETILO; C, 5-BENZOIL-1,2-DIHIDRO-3H-PIRROLO(1,2-A)PIRROL-1-CARBETOXI Y R H. SE UTILIZAN COMO ANTIINFLAMATORIOS Y ANALGESICOS.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES550085A ES8606352A1 (es) | 1985-12-18 | 1985-12-18 | Procedimiento de preparacion de derivados del pirrol |
| PT83428A PT83428B (pt) | 1985-12-18 | 1986-09-24 | Processo de preparacao de derivados do pirrol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES550085A ES8606352A1 (es) | 1985-12-18 | 1985-12-18 | Procedimiento de preparacion de derivados del pirrol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES8606352A1 true ES8606352A1 (es) | 1986-04-01 |
| ES550085A0 ES550085A0 (es) | 1986-04-01 |
Family
ID=8490475
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES550085A Expired ES8606352A1 (es) | 1985-12-18 | 1985-12-18 | Procedimiento de preparacion de derivados del pirrol |
Country Status (2)
| Country | Link |
|---|---|
| ES (1) | ES8606352A1 (es) |
| PT (1) | PT83428B (es) |
-
1985
- 1985-12-18 ES ES550085A patent/ES8606352A1/es not_active Expired
-
1986
- 1986-09-24 PT PT83428A patent/PT83428B/pt not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| PT83428A (en) | 1986-10-01 |
| ES550085A0 (es) | 1986-04-01 |
| PT83428B (pt) | 1988-07-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19970612 |