ES8605782A1 - N-Hydroxy-ethyl nicotinamide nitrate ester prodn. - Google Patents
N-Hydroxy-ethyl nicotinamide nitrate ester prodn.Info
- Publication number
- ES8605782A1 ES8605782A1 ES549223A ES549223A ES8605782A1 ES 8605782 A1 ES8605782 A1 ES 8605782A1 ES 549223 A ES549223 A ES 549223A ES 549223 A ES549223 A ES 549223A ES 8605782 A1 ES8605782 A1 ES 8605782A1
- Authority
- ES
- Spain
- Prior art keywords
- nitrate ester
- hydroxy
- prodn
- formula
- nicotinamide nitrate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Pyridine Compounds (AREA)
Abstract
The nitrate ester of N-(2-hydroxyethyl) nicotinamide of formula (I) is made by reaction of nicotinoyl imidazolide of formula (II) with a nitrate ester of 2-hydroxy ethylamine of formula H2NCH2CH2ONO2 (III) in presence of an inert organic solvent e.g. ethers or alkyl halides under mild anhydrous conditions, for 1-6 hours, to obtain (I) and its salts with organic or inorganic acids.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES549223A ES8605782A1 (en) | 1985-11-22 | 1985-11-22 | N-Hydroxy-ethyl nicotinamide nitrate ester prodn. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES549223A ES8605782A1 (en) | 1985-11-22 | 1985-11-22 | N-Hydroxy-ethyl nicotinamide nitrate ester prodn. |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8605782A1 true ES8605782A1 (en) | 1986-04-01 |
ES549223A0 ES549223A0 (en) | 1986-04-01 |
Family
ID=8490257
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES549223A Expired ES8605782A1 (en) | 1985-11-22 | 1985-11-22 | N-Hydroxy-ethyl nicotinamide nitrate ester prodn. |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES8605782A1 (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012089769A1 (en) | 2010-12-28 | 2012-07-05 | Procos S.P.A. | Process for the manufacture of nicorandil |
-
1985
- 1985-11-22 ES ES549223A patent/ES8605782A1/en not_active Expired
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2012089769A1 (en) | 2010-12-28 | 2012-07-05 | Procos S.P.A. | Process for the manufacture of nicorandil |
Also Published As
Publication number | Publication date |
---|---|
ES549223A0 (en) | 1986-04-01 |
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