ES8605782A1 - N-Hydroxy-ethyl nicotinamide nitrate ester prodn. - Google Patents

N-Hydroxy-ethyl nicotinamide nitrate ester prodn.

Info

Publication number
ES8605782A1
ES8605782A1 ES549223A ES549223A ES8605782A1 ES 8605782 A1 ES8605782 A1 ES 8605782A1 ES 549223 A ES549223 A ES 549223A ES 549223 A ES549223 A ES 549223A ES 8605782 A1 ES8605782 A1 ES 8605782A1
Authority
ES
Spain
Prior art keywords
nitrate ester
hydroxy
prodn
formula
nicotinamide nitrate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES549223A
Other languages
Spanish (es)
Other versions
ES549223A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
BERENGUER BENEYTO LAB
Original Assignee
BERENGUER BENEYTO LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by BERENGUER BENEYTO LAB filed Critical BERENGUER BENEYTO LAB
Priority to ES549223A priority Critical patent/ES8605782A1/en
Publication of ES8605782A1 publication Critical patent/ES8605782A1/en
Publication of ES549223A0 publication Critical patent/ES549223A0/en
Expired legal-status Critical Current

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Abstract

The nitrate ester of N-(2-hydroxyethyl) nicotinamide of formula (I) is made by reaction of nicotinoyl imidazolide of formula (II) with a nitrate ester of 2-hydroxy ethylamine of formula H2NCH2CH2ONO2 (III) in presence of an inert organic solvent e.g. ethers or alkyl halides under mild anhydrous conditions, for 1-6 hours, to obtain (I) and its salts with organic or inorganic acids.
ES549223A 1985-11-22 1985-11-22 N-Hydroxy-ethyl nicotinamide nitrate ester prodn. Expired ES8605782A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES549223A ES8605782A1 (en) 1985-11-22 1985-11-22 N-Hydroxy-ethyl nicotinamide nitrate ester prodn.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES549223A ES8605782A1 (en) 1985-11-22 1985-11-22 N-Hydroxy-ethyl nicotinamide nitrate ester prodn.

Publications (2)

Publication Number Publication Date
ES8605782A1 true ES8605782A1 (en) 1986-04-01
ES549223A0 ES549223A0 (en) 1986-04-01

Family

ID=8490257

Family Applications (1)

Application Number Title Priority Date Filing Date
ES549223A Expired ES8605782A1 (en) 1985-11-22 1985-11-22 N-Hydroxy-ethyl nicotinamide nitrate ester prodn.

Country Status (1)

Country Link
ES (1) ES8605782A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012089769A1 (en) 2010-12-28 2012-07-05 Procos S.P.A. Process for the manufacture of nicorandil

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2012089769A1 (en) 2010-12-28 2012-07-05 Procos S.P.A. Process for the manufacture of nicorandil

Also Published As

Publication number Publication date
ES549223A0 (en) 1986-04-01

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