ES8605757A1 - Un procedimiento de preparacion de derivados del acido melilotico - Google Patents

Un procedimiento de preparacion de derivados del acido melilotico

Info

Publication number
ES8605757A1
ES8605757A1 ES530498A ES530498A ES8605757A1 ES 8605757 A1 ES8605757 A1 ES 8605757A1 ES 530498 A ES530498 A ES 530498A ES 530498 A ES530498 A ES 530498A ES 8605757 A1 ES8605757 A1 ES 8605757A1
Authority
ES
Spain
Prior art keywords
acid
derivatives
carbon atoms
reaction
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530498A
Other languages
English (en)
Other versions
ES530498A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RICHARD LAB M
Original Assignee
RICHARD LAB M
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RICHARD LAB M filed Critical RICHARD LAB M
Publication of ES8605757A1 publication Critical patent/ES8605757A1/es
Publication of ES530498A0 publication Critical patent/ES530498A0/es
Granted legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO MELILOTICO QUE RESPONDE A LA FORMULA GENERAL (I), EN LA QUE X ES UN ATOMO DE HALOGENO, PRINCIPALMENTE CL O F, Y SUS SALES TALES COMO LAS DE METALES ALCALINOS, ALCALINOTERREOS O DE AMONIO, Y LOS ESTERES ALQUILICOS DE 1 A 4 ATOMOS DE CARBONO. COMPRENDE LAS SIGUIENTES ETAPAS: PRIMERA, SE HACE REACCIONAR UN HALOGENOFENOL CON CLOROFORMO Y UN ALCALI, PARA FORMAR UN ALDEHIDO DEL HALOGENOFENOL; SEGUNDA, SE CONDENSA EL ALDEHIDO CON ANHIDRIDO ACETICO EN PRESENCIA DE ACETATO POTASICO; TERCERA, SE HALOGENA EL ACIDO OBTENIDO PARA FORMAR EL DERIVADO HALOGENADO DEL ACIDO ACETIL-MELILOTICO; Y POR ULTIMO, EVENTUALMENTE, SE TRANSFORMA EL ACIDO EN UNA SAL O EN UN ESTER. DE APLICACION EN LA PREPARACION DE MEDICAMENTOS Y COMPOSICIONES FARMACEUTICAS, POR SUS PROPIEDADES CARDIOVASCULARES Y ANALGESICAS.
ES530498A 1984-02-23 1984-03-09 Un procedimiento de preparacion de derivados del acido melilotico Granted ES530498A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP84400361A EP0153538B1 (fr) 1984-02-23 1984-02-23 Nouveaux dérivés de l'acide mélilotique, et médicaments les contenant

Publications (2)

Publication Number Publication Date
ES8605757A1 true ES8605757A1 (es) 1985-12-16
ES530498A0 ES530498A0 (es) 1985-12-16

Family

ID=8192879

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530498A Granted ES530498A0 (es) 1984-02-23 1984-03-09 Un procedimiento de preparacion de derivados del acido melilotico

Country Status (4)

Country Link
EP (1) EP0153538B1 (es)
AT (1) ATE23852T1 (es)
DE (1) DE3461461D1 (es)
ES (1) ES530498A0 (es)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2995598A (en) * 1958-02-27 1961-08-08 Smith Miller & Patch Inc Beta(ortho-acetoxyphenyl)propionic acid and salts thereof
FR2473039A1 (fr) * 1980-01-07 1981-07-10 Richard Sa Laboratoire M Nouveau medicament antiagregant plaquettaire et analgesique a base d'acide acetyl melilotique

Also Published As

Publication number Publication date
ES530498A0 (es) 1985-12-16
EP0153538B1 (fr) 1986-11-26
EP0153538A1 (fr) 1985-09-04
ATE23852T1 (de) 1986-12-15
DE3461461D1 (en) 1987-01-15

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 20050906