ES8604917A3 - Prepn. of ranitidine for treatment of ulcers - by reacting 2-(((5-(di:methylamino)-methyl-2-furanyl) methyl) thio ethanamine with 1-nitro-3-methyl ketenimine - Google Patents

Prepn. of ranitidine for treatment of ulcers - by reacting 2-(((5-(di:methylamino)-methyl-2-furanyl) methyl) thio ethanamine with 1-nitro-3-methyl ketenimine

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Publication number
ES8604917A3
ES8604917A3 ES85543966A ES543966A ES8604917A3 ES 8604917 A3 ES8604917 A3 ES 8604917A3 ES 85543966 A ES85543966 A ES 85543966A ES 543966 A ES543966 A ES 543966A ES 8604917 A3 ES8604917 A3 ES 8604917A3
Authority
ES
Spain
Prior art keywords
methyl
nitro
thio
ketenimine
furanyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES85543966A
Other languages
Spanish (es)
Other versions
ES543966A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Medichem SA
Original Assignee
Medichem SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from YU2608/82A external-priority patent/YU42819B/en
Application filed by Medichem SA filed Critical Medichem SA
Priority to ES543966A priority Critical patent/ES543966A0/en
Publication of ES8604917A3 publication Critical patent/ES8604917A3/en
Publication of ES543966A0 publication Critical patent/ES543966A0/en
Granted legal-status Critical Current

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Abstract

N-(2-(((5-dimethylamino methyl 2-furanyl) methyl) thio) ethyl) N'-methyl 2-nitro 1,1-ethene diamine of formula (I) is made by (a) treating a soln. of 1-methyl-thio- 1-methylamino 2-nitro ethene (IV) with a heavy metal salt selected from AgNO3, CoCl2, CoCl or HgCl, in organic solvent, e.g. methanol or acetonitrile, in presence of triethylamine and at ambient temp. to produce 1-nitro-3-methyl ketenimine CH3-N=C=CH-NO2 (III); and (b) reacting this with a cpd. of formula (II) at ambient temp. in presence of triethylamine and in methanol or acetonitrile to obtain (I) and its acceptable addn. salts.
ES543966A 1982-11-22 1985-06-07 PROCEDURE FOR THE PREPARATION OF N- (2 - ((((5- (DIMETILA-MINO) -METIL-2-FURANIL) METHYL) THIO) ETIL) -N'-METHYL-2-NITRO-1,1- ETENDIAMINE Granted ES543966A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES543966A ES543966A0 (en) 1982-11-22 1985-06-07 PROCEDURE FOR THE PREPARATION OF N- (2 - ((((5- (DIMETILA-MINO) -METIL-2-FURANIL) METHYL) THIO) ETIL) -N'-METHYL-2-NITRO-1,1- ETENDIAMINE

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
YU2608/82A YU42819B (en) 1982-11-22 1982-11-22 Process for preparing n-/2-///5-(dimethyl-amino)-methyl-2-furanyl/methyl/thio/ethyl-n'-methyl-2-nitro-1,1-ethene diamine
ES543966A ES543966A0 (en) 1982-11-22 1985-06-07 PROCEDURE FOR THE PREPARATION OF N- (2 - ((((5- (DIMETILA-MINO) -METIL-2-FURANIL) METHYL) THIO) ETIL) -N'-METHYL-2-NITRO-1,1- ETENDIAMINE

Publications (2)

Publication Number Publication Date
ES8604917A3 true ES8604917A3 (en) 1986-03-01
ES543966A0 ES543966A0 (en) 1986-03-01

Family

ID=26156106

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543966A Granted ES543966A0 (en) 1982-11-22 1985-06-07 PROCEDURE FOR THE PREPARATION OF N- (2 - ((((5- (DIMETILA-MINO) -METIL-2-FURANIL) METHYL) THIO) ETIL) -N'-METHYL-2-NITRO-1,1- ETENDIAMINE

Country Status (1)

Country Link
ES (1) ES543966A0 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036479A1 (en) * 1990-11-09 1993-05-16 Richter Gedeon Vegyeszet Procedure for preparing 1 - (- 2 - ((5-dimethylamine-2-furyl) -metiltio) -amino-1-methylamino-2-nitroethylene. (Machine-translation by Google Translate, not legally binding)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2036479A1 (en) * 1990-11-09 1993-05-16 Richter Gedeon Vegyeszet Procedure for preparing 1 - (- 2 - ((5-dimethylamine-2-furyl) -metiltio) -amino-1-methylamino-2-nitroethylene. (Machine-translation by Google Translate, not legally binding)

Also Published As

Publication number Publication date
ES543966A0 (en) 1986-03-01

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