ES8603506A1 - Azahomoerythromycin B derivatives and intermediates thereof. - Google Patents
Azahomoerythromycin B derivatives and intermediates thereof.Info
- Publication number
- ES8603506A1 ES8603506A1 ES535624A ES535624A ES8603506A1 ES 8603506 A1 ES8603506 A1 ES 8603506A1 ES 535624 A ES535624 A ES 535624A ES 535624 A ES535624 A ES 535624A ES 8603506 A1 ES8603506 A1 ES 8603506A1
- Authority
- ES
- Spain
- Prior art keywords
- homoerythromycin
- aza
- intermediates
- deoxo
- azahomoerythromycin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Oncology (AREA)
- Animal Behavior & Ethology (AREA)
- Communicable Diseases (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
9-Deoxo-9a-methyl-9a-aza- 9a-homoerythromycin B (I) and 4"-epi-9-deoxo-9a-methyl- 9a-aza-9a-homoerythromycin B (IA) of formula (A) and their salts are new. In (A), Q = gp. of formula (a) in (I) or gp. of formula (b) in (IA). - The intermediates 9a-aza-9a-homoerythromycin B (IIa) and 4"-epi-9a-aza-9a-homoerythromycin B (IIb) and their 9-deoxo derivs., and 4"-deoxy-4"-oxo-9-deoxo-9a-methyl -9a-aza-9a-homoerythromycin B (III) and its 2'-O-(2-3C alkanoyl) esters are new.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52982783A | 1983-09-06 | 1983-09-06 |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8603506A1 true ES8603506A1 (en) | 1985-12-16 |
ES535624A0 ES535624A0 (en) | 1985-12-16 |
Family
ID=24111404
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES535624A Granted ES535624A0 (en) | 1983-09-06 | 1984-09-04 | A PROCEDURE FOR THE PREPARATION OF 9-DEOXO-9A-METHYL-9A-AZA-9A-HOMOERYTHROMYCIN B OR A SALT THEREOF |
Country Status (9)
Country | Link |
---|---|
EP (1) | EP0136831B1 (en) |
JP (1) | JPS6072896A (en) |
AT (1) | ATE38519T1 (en) |
CA (1) | CA1239398A (en) |
DE (1) | DE3475073D1 (en) |
DK (1) | DK159450C (en) |
ES (1) | ES535624A0 (en) |
GR (1) | GR80277B (en) |
IE (1) | IE57632B1 (en) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5075289A (en) * | 1988-06-07 | 1991-12-24 | Abbott Laboratories | 9-r-azacyclic erythromycin antibiotics |
US5912331A (en) * | 1991-03-15 | 1999-06-15 | Merck & Co., Inc. | Process for the preparation of 9-deoxo-9(Z)-hydroxyiminoerythromycin A |
US5985844A (en) * | 1992-03-26 | 1999-11-16 | Merck & Co., Inc. | Homoerythromycin A derivatives modified at the 4"-and 8A-positions |
US5189159A (en) * | 1992-04-02 | 1993-02-23 | Merck & Co., Inc. | 8a-AZA-8a-homoerythromycin cyclic iminoethers |
US5215980A (en) * | 1992-01-17 | 1993-06-01 | Merck & Co., Inc. | 10-AZA-9-deoxo-11-deoxy-erythromycin A and derivatives thereof |
US5210235A (en) * | 1992-08-26 | 1993-05-11 | Merck & Co., Inc. | Methods of elaborating erythromycin fragments into amine-containing fragments of azalide antibiotics |
US5332807A (en) * | 1993-04-14 | 1994-07-26 | Merck & Co., Inc. | Process of producing 8A- and 9A-azalide antibiotics |
US6407074B1 (en) | 1997-06-11 | 2002-06-18 | Pfizer Inc | C-4″-substituted macrolide derivatives |
HN1998000074A (en) * | 1997-06-11 | 1999-01-08 | Pfizer Prod Inc | DERIVATIVES FROM MACROLIDES C-4 SUBSTITUTED |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SI7910768A8 (en) * | 1979-04-02 | 1996-06-30 | Pliva Pharm & Chem Works | Process for pripering 11-aza-4-0-cladinosyl-6-0-desosaminyl-15-ethyl- 7,13,14-trihydroxy-3,5,7,9,12,14-hexamethyl- oxacyclopentadecane-2-one and their derivatives |
SI8110592A8 (en) * | 1981-03-06 | 1996-06-30 | Pliva Pharm & Chem Works | Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof |
US4382085A (en) * | 1982-03-01 | 1983-05-03 | Pfizer Inc. | 4"-Epi erythromycin A and derivatives thereof as useful antibacterial agents |
US4496546A (en) * | 1982-04-12 | 1985-01-29 | Pfizer Inc. | Erythromycin D and esters thereof |
US4474768A (en) * | 1982-07-19 | 1984-10-02 | Pfizer Inc. | N-Methyl 11-aza-10-deoxo-10-dihydro-erytromycin A, intermediates therefor |
PH19293A (en) * | 1982-11-15 | 1986-03-04 | Pfizer | Epimeric azahomoerythromycin,pharmaceutical composition containing the same and method of use thereof |
-
1984
- 1984-09-03 DE DE8484306009T patent/DE3475073D1/en not_active Expired
- 1984-09-03 EP EP84306009A patent/EP0136831B1/en not_active Expired
- 1984-09-03 GR GR80277A patent/GR80277B/en unknown
- 1984-09-03 AT AT84306009T patent/ATE38519T1/en not_active IP Right Cessation
- 1984-09-04 CA CA000462343A patent/CA1239398A/en not_active Expired
- 1984-09-04 ES ES535624A patent/ES535624A0/en active Granted
- 1984-09-05 DK DK423084A patent/DK159450C/en not_active IP Right Cessation
- 1984-09-05 IE IE2267/84A patent/IE57632B1/en not_active IP Right Cessation
- 1984-09-06 JP JP59187244A patent/JPS6072896A/en active Pending
Also Published As
Publication number | Publication date |
---|---|
DK423084A (en) | 1985-03-07 |
EP0136831A3 (en) | 1986-03-19 |
EP0136831B1 (en) | 1988-11-09 |
DE3475073D1 (en) | 1988-12-15 |
DK159450B (en) | 1990-10-15 |
GR80277B (en) | 1985-01-04 |
EP0136831A2 (en) | 1985-04-10 |
IE842267L (en) | 1985-03-06 |
JPS6072896A (en) | 1985-04-24 |
DK423084D0 (en) | 1984-09-05 |
DK159450C (en) | 1991-03-18 |
ATE38519T1 (en) | 1988-11-15 |
IE57632B1 (en) | 1993-02-10 |
CA1239398A (en) | 1988-07-19 |
ES535624A0 (en) | 1985-12-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3363686D1 (en) | 4"-keto and-4"-amino-4"-deoxy avermectin compounds and substituted amino derivatives thereof | |
AU5845786A (en) | Pyrano(3,2-C) pyridine derivatives | |
GB8330517D0 (en) | 6-vinyl-furo-(3,4-c)pyridine derivatives | |
ES8603506A1 (en) | Azahomoerythromycin B derivatives and intermediates thereof. | |
GB2165237B (en) | 1,3-oxazolidine-2-one derivatives | |
IL72432A0 (en) | Anthracyclin derivatives,a process for their preparation and their use as cytostatic agents | |
AU6401490A (en) | 2'-deoxy-4'-thioribonucleosides as antiviral and anticancer agents | |
AU5083385A (en) | Printing plate for offset printing | |
PH21312A (en) | 4,5,6,7-tetrahydrothiazole (5,4-c) pyridine derivatives | |
DE3279073D1 (en) | Plasmid p sg 2 and process for its production | |
FI883812A0 (en) | 4'-DESHYDROXIEPIPODOFYLLOTOXIN -GLUKOSIDER, SYNTES OCH ANVAENDNING. | |
CS675186A2 (en) | Zpusob vyroby novych 12 a 13 substituovanych derivatu ergolinu | |
SE8504657D0 (en) | NEW 5-FLUORO-2'-DEOXIURIDIN DERIVATIVES AND STATES THEREOF, PROCEDURES FOR THEIR PREPARATION AND ANTITUMOR AGENTS CONTAINING THESE | |
IE780610L (en) | Dimeric indole-dihydroindoles | |
DE3362287D1 (en) | Improvements in or relating to de(mycinosyloxy)tylosin derivatives | |
GR65242B (en) | Method for the preparation of 2-n-acyl and alkyl-6'-n-alkyl-and 6',6'-di-n-alkyl derivatives of fortimicin a and b | |
FR2460917B1 (en) | ||
GB2010814A (en) | 2'-n-substituted fortimicin b and derivatives | |
ZA854877B (en) | 4h-pyrimido(2,1a)isoquinolin-4-one derivatives | |
AU571273B2 (en) | Bis(3,5-dioxopiperazine)-ethane derivatives | |
ES8602007A1 (en) | 2,6-dioxa-bicyclo-û2,2,2-octan-7-yl-acetaldehydes | |
DK132386A (en) | 5H-PYRIDO (3 ', 4'.4,5) PYRROLO (3,2-C) PYRIDINE DERIVATIVES AND PROCEDURES FOR PREPARING THEREOF | |
DE3565268D1 (en) | Novel tylosin derivatives | |
PT80882A (en) | 4-substituted-1,2,4,6-thiatrizine derivatives | |
GB8407082D0 (en) | Furo-(3,4-c)pyridine derivatives |