ES8601929A1 - Procedimiento de fabricacion de benzodiazepinas cianetiladas - Google Patents

Procedimiento de fabricacion de benzodiazepinas cianetiladas

Info

Publication number
ES8601929A1
ES8601929A1 ES539059A ES539059A ES8601929A1 ES 8601929 A1 ES8601929 A1 ES 8601929A1 ES 539059 A ES539059 A ES 539059A ES 539059 A ES539059 A ES 539059A ES 8601929 A1 ES8601929 A1 ES 8601929A1
Authority
ES
Spain
Prior art keywords
benzodiazepin
acyloxy
ethylated
prepn
cyano
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES539059A
Other languages
English (en)
Other versions
ES539059A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Gerot Pharmazeutika GmbH
Original Assignee
Gerot Pharmazeutika GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gerot Pharmazeutika GmbH filed Critical Gerot Pharmazeutika GmbH
Publication of ES539059A0 publication Critical patent/ES539059A0/es
Publication of ES8601929A1 publication Critical patent/ES8601929A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton

Abstract

PROCEDIMIENTO DE FABRICACION DE BENZODIAZEPINAS CIANETILADAS.CONSISTE EN TRANSFORMAR EN AMBIENTE BASICO 3-ACILOXI-1,4-BENZODIAZEPINAS-2-ONE DE FORMULA (II) CON UNIONES DE FORMULA (III), SAPONIFICANDOSE ACTO SEGUIDO DE FORMA ALCALINA LOS NUEVOS PRODUCTOS INTERMEDIOS DE FORMULA (IV), SIN AISLARLOS, PARA OBTENER BENZODIAZEPINAS CIANETILADAS DE FORMULA (I) DONDE R1 PUEDE SER H, HALOGENO, TRIFLUORMETILO O NITRO, Y R2 PUEDE SER H O HALOGENO.TIENEN UTILIDAD COMO AGENTES HIPNOTICOS.
ES539059A 1984-01-18 1984-12-26 Procedimiento de fabricacion de benzodiazepinas cianetiladas Expired ES8601929A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0015084A AT379391B (de) 1984-01-18 1984-01-18 Verfahren zur herstellung cyanaethylierter benzodiazepine

Publications (2)

Publication Number Publication Date
ES539059A0 ES539059A0 (es) 1985-11-16
ES8601929A1 true ES8601929A1 (es) 1985-11-16

Family

ID=3482860

Family Applications (1)

Application Number Title Priority Date Filing Date
ES539059A Expired ES8601929A1 (es) 1984-01-18 1984-12-26 Procedimiento de fabricacion de benzodiazepinas cianetiladas

Country Status (6)

Country Link
KR (1) KR910006989B1 (es)
AT (1) AT379391B (es)
ES (1) ES8601929A1 (es)
NO (1) NO161672C (es)
NZ (1) NZ210740A (es)
PT (1) PT79831B (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101923058B1 (ko) * 2012-04-30 2019-02-20 김영진 고유전 고분자 복합 조성물 및 이를 이용한 에너지 저장 소자

Also Published As

Publication number Publication date
NO850189L (no) 1985-07-19
PT79831A (en) 1985-02-01
KR910006989B1 (ko) 1991-09-14
KR850005420A (ko) 1985-08-26
NZ210740A (en) 1987-07-31
ATA15084A (de) 1984-11-15
NO161672C (no) 1989-09-13
NO161672B (no) 1989-06-05
PT79831B (en) 1986-10-28
ES539059A0 (es) 1985-11-16
AT379391B (de) 1985-12-27

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