ES8600209A1 - Mejoras en la preparacion de cristales grandes del acido n-benciloxicarbonil-l-aspartico - Google Patents
Mejoras en la preparacion de cristales grandes del acido n-benciloxicarbonil-l-asparticoInfo
- Publication number
- ES8600209A1 ES8600209A1 ES535388A ES535388A ES8600209A1 ES 8600209 A1 ES8600209 A1 ES 8600209A1 ES 535388 A ES535388 A ES 535388A ES 535388 A ES535388 A ES 535388A ES 8600209 A1 ES8600209 A1 ES 8600209A1
- Authority
- ES
- Spain
- Prior art keywords
- benzyloxycarbonyl
- aspartic acid
- crystals
- preparation
- large crystals
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- XYXYXSKSTZAEJW-VIFPVBQESA-N (2s)-2-(phenylmethoxycarbonylamino)butanedioic acid Chemical compound OC(=O)C[C@@H](C(O)=O)NC(=O)OCC1=CC=CC=C1 XYXYXSKSTZAEJW-VIFPVBQESA-N 0.000 title abstract 4
- 239000013078 crystal Substances 0.000 title abstract 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 108010011485 Aspartame Proteins 0.000 abstract 1
- 108010016626 Dipeptides Proteins 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- IAOZJIPTCAWIRG-QWRGUYRKSA-N aspartame Chemical compound OC(=O)C[C@H](N)C(=O)N[C@H](C(=O)OC)CC1=CC=CC=C1 IAOZJIPTCAWIRG-QWRGUYRKSA-N 0.000 abstract 1
- 229960003438 aspartame Drugs 0.000 abstract 1
- 235000010357 aspartame Nutrition 0.000 abstract 1
- 239000000605 aspartame Substances 0.000 abstract 1
- 238000002425 crystallisation Methods 0.000 abstract 1
- 230000008025 crystallization Effects 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 229910052751 metal Inorganic materials 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C269/00—Preparation of derivatives of carbamic acid, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
- C07C269/08—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Peptides Or Proteins (AREA)
- Seasonings (AREA)
Abstract
MEJORAS EN LA PREPARACION DE CRISTALES GRANDES DEL ACIDO N-BENCILOXICARBONIL-L-ASPARTICO.CONSISTENTES EN: ADIFICAR CON CLH A LA SOLUCION ACUOSA DE UNA SAL DE METALDIALCALI DE ACIDO N-BENCILOXICARBONIL-L-ASPARTICO A UN PH H 2,5; CALENTAR LA SOLUCION ACUOSA DE LA SAL DE METAL DIALCALI DE ACIDO N-BENCILOXICARBONIL-L-ASPARTICO A UNA TEMPERATURA ENTRE 20J Y 45JC; ENFRIAR POR DEBAJO DE 10JC A LA SOLUCION ACUOSA DE LA SAL DE METAL DIALCALI DE ACIDO N-BENCILOXICARBONIL CALENTADA A 20JC; Y AN/ADIR CRISTALES SEMINALES DE ACIDO N-BENCILOXICARBONIL-L-ASPARTICO A UNA SOLUCION ACUOSA DE UNA SAL DE METAL DIALCALI DE ACIDO N-BENCILOXICARBONIL-L-ASPARTICO, ADIFICADA Y CALENTADA ENTRE 20 Y 45JC.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/526,580 US4570015A (en) | 1983-08-26 | 1983-08-26 | Preparation of large crystals of N-benzyloxycarbonyl-L-aspartic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES535388A0 ES535388A0 (es) | 1985-10-01 |
| ES8600209A1 true ES8600209A1 (es) | 1985-10-01 |
Family
ID=24097911
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES535388A Expired ES8600209A1 (es) | 1983-08-26 | 1984-08-24 | Mejoras en la preparacion de cristales grandes del acido n-benciloxicarbonil-l-aspartico |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US4570015A (es) |
| JP (1) | JPS60185755A (es) |
| KR (1) | KR850001770A (es) |
| DE (1) | DE3431246A1 (es) |
| ES (1) | ES8600209A1 (es) |
| FR (1) | FR2551060A1 (es) |
| GB (1) | GB2149397A (es) |
| IT (1) | IT1177976B (es) |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH553751A (de) * | 1970-05-19 | 1974-09-13 | Stamicarbon | Verfahren zur herstellung von aspartylaminosaeure-estern. |
| US3957864A (en) * | 1975-03-31 | 1976-05-18 | Commercial Solvents Corporation | Process for recovery of 1-glutamic acid |
| JPS56110661A (en) * | 1980-02-04 | 1981-09-01 | Ajinomoto Co Inc | Preparation of n-benzyloxycarbonyl-l-aspartic acid |
| US4293706A (en) * | 1980-06-19 | 1981-10-06 | Ppg Industries, Inc. | Preparation of N-benzyloxycarbonyl aspartic acid |
| US4450284A (en) * | 1981-08-10 | 1984-05-22 | Ppg Industries, Inc. | Method for purifying N-benzyloxycarbonyl aspartic acid |
-
1983
- 1983-08-26 US US06/526,580 patent/US4570015A/en not_active Expired - Lifetime
-
1984
- 1984-08-21 GB GB08421156A patent/GB2149397A/en not_active Withdrawn
- 1984-08-24 ES ES535388A patent/ES8600209A1/es not_active Expired
- 1984-08-24 FR FR8413226A patent/FR2551060A1/fr not_active Withdrawn
- 1984-08-24 DE DE19843431246 patent/DE3431246A1/de not_active Withdrawn
- 1984-08-25 KR KR1019840005196A patent/KR850001770A/ko not_active Application Discontinuation
- 1984-08-27 IT IT48762/84A patent/IT1177976B/it active
- 1984-08-27 JP JP59176885A patent/JPS60185755A/ja active Granted
Also Published As
| Publication number | Publication date |
|---|---|
| GB8421156D0 (en) | 1984-09-26 |
| ES535388A0 (es) | 1985-10-01 |
| IT8448762A1 (it) | 1986-02-27 |
| GB2149397A (en) | 1985-06-12 |
| IT8448762A0 (it) | 1984-08-27 |
| JPS60185755A (ja) | 1985-09-21 |
| DE3431246A1 (de) | 1985-03-21 |
| FR2551060A1 (fr) | 1985-03-01 |
| US4570015A (en) | 1986-02-11 |
| JPH0587501B2 (es) | 1993-12-16 |
| KR850001770A (ko) | 1985-04-01 |
| IT1177976B (it) | 1987-09-03 |
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