ES8506721A1 - Penam deriv. prodn. - Google Patents

Penam deriv. prodn.

Info

Publication number
ES8506721A1
ES8506721A1 ES531428A ES531428A ES8506721A1 ES 8506721 A1 ES8506721 A1 ES 8506721A1 ES 531428 A ES531428 A ES 531428A ES 531428 A ES531428 A ES 531428A ES 8506721 A1 ES8506721 A1 ES 8506721A1
Authority
ES
Spain
Prior art keywords
derivs
formula
acid adduct
tetraaza
cpds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES531428A
Other languages
Spanish (es)
Other versions
ES531428A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8506721A1 publication Critical patent/ES8506721A1/en
Publication of ES531428A0 publication Critical patent/ES531428A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Display Devices Of Pinball Game Machines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Prepn. of pyrazolo-benzadiazepin (derivs. of the formula (I) (where R' is H or methyl, R2 is methyl or ethyl and n is 2 or 3) is claimed. - The process comprises (i) methylating or alkylating to corresponding piperazinyl-tetraaza tricyclic cpds. or (ii) acylating the tetraaza tricyclic cpds. of the formula (II) (where R' is as above) with acetic acid derivs. of the formula (III) (where R2 and n are as above and Z is an exit gp.). - Opt. the obtd. bases are converted to acid adduct salts or the acid adduct salts are converted to free bases or pharmacologically acceptable acid adduct salts. - (I) and their derivs. are gastrointestinally active. (First major country equivalent to DK8200439-A)
ES531428A 1982-01-22 1984-04-09 A PROCEDURE FOR THE PREPARATION OF A PENAM DERIVATIVE Granted ES531428A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8201754 1982-01-22

Publications (2)

Publication Number Publication Date
ES8506721A1 true ES8506721A1 (en) 1985-07-16
ES531428A0 ES531428A0 (en) 1985-07-16

Family

ID=10527792

Family Applications (2)

Application Number Title Priority Date Filing Date
ES519191A Granted ES519191A0 (en) 1982-01-22 1983-01-21 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF PENAM.
ES531428A Granted ES531428A0 (en) 1982-01-22 1984-04-09 A PROCEDURE FOR THE PREPARATION OF A PENAM DERIVATIVE

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES519191A Granted ES519191A0 (en) 1982-01-22 1983-01-21 A PROCEDURE FOR THE PREPARATION OF A DERIVATIVE OF PENAM.

Country Status (12)

Country Link
KR (1) KR840003257A (en)
AT (2) AT381095B (en)
CA (1) CA1202959A (en)
DK (1) DK23083A (en)
ES (2) ES519191A0 (en)
FI (1) FI830193L (en)
GR (1) GR77868B (en)
JO (1) JO1228B1 (en)
MX (1) MX155039A (en)
NO (1) NO830184L (en)
PL (2) PL240237A1 (en)
PT (1) PT76127A (en)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE811314A (en) * 1973-03-15 1974-08-20 PROCESS FOR THE PREPARATION OF CEPHALOSPORINS AND PENICILLINS
NZ195030A (en) * 1979-10-09 1983-06-17 Beecham Group Ltd Preparation of 6 -methoxy-penam derivatives

Also Published As

Publication number Publication date
PL240237A1 (en) 1984-02-27
PT76127A (en) 1983-02-01
FI830193A0 (en) 1983-01-20
NO830184L (en) 1983-07-25
MX155039A (en) 1988-01-22
AT384611B (en) 1987-12-10
FI830193L (en) 1983-07-23
ES8407054A1 (en) 1984-08-16
KR840003257A (en) 1984-08-20
AT381095B (en) 1986-08-25
DK23083A (en) 1983-07-23
CA1202959A (en) 1986-04-08
JO1228B1 (en) 1985-04-20
ATA20483A (en) 1986-01-15
ATA256085A (en) 1987-05-15
ES519191A0 (en) 1984-08-16
ES531428A0 (en) 1985-07-16
PL244195A1 (en) 1984-09-10
GR77868B (en) 1984-09-25
DK23083D0 (en) 1983-01-20

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