ES8504798A1 - Process for the preparation of vincamine - Google Patents

Process for the preparation of vincamine

Info

Publication number
ES8504798A1
ES8504798A1 ES526749A ES526749A ES8504798A1 ES 8504798 A1 ES8504798 A1 ES 8504798A1 ES 526749 A ES526749 A ES 526749A ES 526749 A ES526749 A ES 526749A ES 8504798 A1 ES8504798 A1 ES 8504798A1
Authority
ES
Spain
Prior art keywords
vincamine
temperature
preparation
subjected
tabersonin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES526749A
Other languages
Spanish (es)
Other versions
ES526749A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT23905/82A external-priority patent/IT1153301B/en
Priority claimed from IT19861/83A external-priority patent/IT1161203B/en
Application filed by Individual filed Critical Individual
Publication of ES8504798A1 publication Critical patent/ES8504798A1/en
Publication of ES526749A0 publication Critical patent/ES526749A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D461/00—Heterocyclic compounds containing indolo [3,2,1-d,e] pyrido [3,2,1,j] [1,5]-naphthyridine ring systems, e.g. vincamine

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Steroid Compounds (AREA)

Abstract

To prepare vincamine from vincadifformin or tabersonin, the starting compound is subjected to an oxidation with a peracid in the presence of a protecting agent from amongst the group of the copper salts and oxalic acid, care being taken that the temperature does not exceed 5 DEG C and is preferably in the range from -5 DEG C to 0 DEG C. The reaction mixture obtained is subsequently subjected to a rearrangement at a monitored acidic pH while heating and keeping the mixture at a temperature from 30 to 35 DEG C.
ES526749A 1982-10-25 1983-10-25 PROCEDURE FOR THE PREPARATION OF VINCAMINA Granted ES526749A0 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT23905/82A IT1153301B (en) 1982-10-25 1982-10-25 Vincamine and 14,15-dehydro-vincamine prepn
IT19861/83A IT1161203B (en) 1983-03-02 1983-03-02 Vincamine and 14,15-dehydro-vincamine prepn

Publications (2)

Publication Number Publication Date
ES8504798A1 true ES8504798A1 (en) 1985-04-16
ES526749A0 ES526749A0 (en) 1985-04-16

Family

ID=26327335

Family Applications (1)

Application Number Title Priority Date Filing Date
ES526749A Granted ES526749A0 (en) 1982-10-25 1983-10-25 PROCEDURE FOR THE PREPARATION OF VINCAMINA

Country Status (4)

Country Link
CH (1) CH657617A5 (en)
DE (1) DE3338705A1 (en)
ES (1) ES526749A0 (en)
FR (1) FR2534920A1 (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102276599B (en) * 2011-08-18 2012-10-17 张家口市格瑞高新技术有限公司 Process for preparing vincamine by semisynthetic method

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH625239A5 (en) * 1974-08-09 1981-09-15 Buskine Sa
FR2332280A1 (en) * 1975-11-20 1977-06-17 Kunesch Nicole Vincamine and (16)-epivincamine prepn. - from tabersonine salt by hydrogenating and oxidative rearrangement

Also Published As

Publication number Publication date
FR2534920A1 (en) 1984-04-27
DE3338705A1 (en) 1984-04-26
CH657617A5 (en) 1986-09-15
FR2534920B3 (en) 1985-03-01
ES526749A0 (en) 1985-04-16

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