ES8504710A1 - Process for the optical resolution of a mixture of the enantiomers of trans-3-((4-methoxyphenoxy)-methyl)-1-methyl-4-phenylpiperidine. - Google Patents

Process for the optical resolution of a mixture of the enantiomers of trans-3-((4-methoxyphenoxy)-methyl)-1-methyl-4-phenylpiperidine.

Info

Publication number
ES8504710A1
ES8504710A1 ES530355A ES530355A ES8504710A1 ES 8504710 A1 ES8504710 A1 ES 8504710A1 ES 530355 A ES530355 A ES 530355A ES 530355 A ES530355 A ES 530355A ES 8504710 A1 ES8504710 A1 ES 8504710A1
Authority
ES
Spain
Prior art keywords
methyl
phenylpiperidine
methoxyphenoxy
enantiomers
trans
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES530355A
Other languages
Spanish (es)
Other versions
ES530355A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferrosan ApS
Original Assignee
Ferrosan ApS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferrosan ApS filed Critical Ferrosan ApS
Publication of ES8504710A1 publication Critical patent/ES8504710A1/en
Publication of ES530355A0 publication Critical patent/ES530355A0/en
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/20—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms
    • C07D211/22—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by singly bound oxygen or sulphur atoms by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

A mixture of enantiomers of trans-3-[(4-methoxyphenoxy)-methyl]-1-methyl-4-phenylpiperidine is separated into the optically active pure forms by reacting it with an enantiomer of mandelic acid or a derivative thereof to form two diastereomeric compounds and by precipitating one of the diastereomeric compounds formed. The precipitated compound is subsequently separated and is optionally converted into the free base or a pharmaceutically acceptable salt thereof. The yield obtained is substantially higher than the yield obtained by a prior art process employing a tartaric acid derivative as resolving agent.
ES530355A 1983-03-07 1984-03-07 PROCEDURE FOR THE OPTICAL RESOLUTION OF A MIXTURE OF ENANTIOMERS OF A DERIVATIVE OF PIPERIDINE. Granted ES530355A0 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK111583A DK149624C (en) 1983-03-07 1983-03-07 PROCEDURE FOR THE PREPARATION OF (+) - TRANS-3 - (((4-METHOXYPHENOXY) -METHYL) -1-METHYL-4-PHENYLPIPERIDINE OR A PHARMACEUTICAL ACCEPTABLE SALT FROM A MIXTURE OF ENANTIOMY

Publications (2)

Publication Number Publication Date
ES8504710A1 true ES8504710A1 (en) 1985-05-01
ES530355A0 ES530355A0 (en) 1985-05-01

Family

ID=8101175

Family Applications (1)

Application Number Title Priority Date Filing Date
ES530355A Granted ES530355A0 (en) 1983-03-07 1984-03-07 PROCEDURE FOR THE OPTICAL RESOLUTION OF A MIXTURE OF ENANTIOMERS OF A DERIVATIVE OF PIPERIDINE.

Country Status (12)

Country Link
US (1) US4571424A (en)
EP (1) EP0123832B1 (en)
JP (1) JPS6069065A (en)
AT (1) ATE30910T1 (en)
CA (1) CA1257599A (en)
DE (1) DE3467574D1 (en)
DK (1) DK149624C (en)
ES (1) ES530355A0 (en)
FI (1) FI80261C (en)
GR (1) GR81929B (en)
IE (1) IE57002B1 (en)
NO (1) NO164594C (en)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE66332B1 (en) * 1986-11-03 1995-12-27 Novo Nordisk As Piperidine compounds and their preparation and use
US5254556A (en) * 1988-11-07 1993-10-19 Janssen Pharmaceutica N.V. 3-piperidinyl-1,2-benzisoxazoles
IL98757A (en) * 1990-07-18 1997-01-10 Novo Nordisk As Piperidine derivatives their preparation and pharmaceutical compositions containing them
DE69404306T2 (en) * 1993-05-28 1997-10-30 Pfizer METHOD FOR THE PRODUCTION AND OPTICAL RESOLUTION OF 2-PHENYL-3-AMINOPIPERIDINE
US7470244B2 (en) * 1996-01-26 2008-12-30 Harrison Jr Shelton E Flexion-discouraging splint system, method and device
AU2004271800A1 (en) 2003-09-12 2005-03-24 Pfizer Inc. Combinations comprising alpha-2-delta ligands and serotonin / noradrenaline re-uptake inhibitors
DE102005063192A1 (en) * 2005-12-30 2007-07-05 Basf Ag Producing optically active trans-2,6-dimethylmorpholine useful as an intermediate for fungicides and pharmaceuticals comprises reacting racemic trans-2,6-dimethylmorpholine with optically active mandelic acid

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1422263A (en) * 1973-01-30 1976-01-21 Ferrosan As 4-phenyl-piperidine compounds
US4442113A (en) * 1981-05-07 1984-04-10 A/S Ferrosan Long-term weight reduction of obese patients using femoxetine

Also Published As

Publication number Publication date
CA1257599A (en) 1989-07-18
DK111583A (en) 1984-09-08
FI80261B (en) 1990-01-31
GR81929B (en) 1984-12-12
IE57002B1 (en) 1992-03-11
FI840872A0 (en) 1984-03-05
FI840872A (en) 1984-09-08
NO840847L (en) 1984-09-10
US4571424A (en) 1986-02-18
IE840496L (en) 1984-09-07
ATE30910T1 (en) 1987-12-15
NO164594B (en) 1990-07-16
DK149624C (en) 1987-02-02
JPS6069065A (en) 1985-04-19
FI80261C (en) 1990-05-10
CA1265522C (en) 1990-02-06
NO164594C (en) 1990-10-24
DE3467574D1 (en) 1987-12-23
EP0123832A1 (en) 1984-11-07
DK149624B (en) 1986-08-18
DK111583D0 (en) 1983-03-07
EP0123832B1 (en) 1987-11-19
ES530355A0 (en) 1985-05-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991108