ES8504125A1 - Procedimiento de preparacion de indolinas - Google Patents

Procedimiento de preparacion de indolinas

Info

Publication number
ES8504125A1
ES8504125A1 ES524479A ES524479A ES8504125A1 ES 8504125 A1 ES8504125 A1 ES 8504125A1 ES 524479 A ES524479 A ES 524479A ES 524479 A ES524479 A ES 524479A ES 8504125 A1 ES8504125 A1 ES 8504125A1
Authority
ES
Spain
Prior art keywords
phenyl
substituted
hexaloctahydro
alkanoisoindoles
isoindoles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES524479A
Other languages
English (en)
Other versions
ES524479A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wyeth Holdings LLC
Original Assignee
American Cyanamid Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by American Cyanamid Co filed Critical American Cyanamid Co
Publication of ES8504125A1 publication Critical patent/ES8504125A1/es
Publication of ES524479A0 publication Critical patent/ES524479A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
    • C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/56—Ring systems containing three or more rings
    • C07D209/58—[b]- or [c]-condensed
    • C07D209/72—4,7-Endo-alkylene-iso-indoles
    • C07D209/76—4,7-Endo-alkylene-iso-indoles with oxygen atoms in positions 1 and 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO DE PREPARACION DE INDOLINAS.CONSISTE EN: HIDROGENAR CATALITICAMENTE UNA 2-(FENILO SUSTITUIDO)-5-BICICLO ALQUENO-2,3-DICARBOXIMIDA DE FORMULA (II) CON UN METAL NOBLE CATALIZADOR EN UN SOLVENTE ORGANICO A TEMPERATURA AMBIENTE Y 2-3 ATMOSFERAS DE PRESION PARA OBTENER 2-(FENILO SUSTITUIDO)-5-BICICLO-ALCANO-2,3-DICARBOXIAMIDA DE FORMULA (III); Y REDUCIR EL BICICLOALCANO CON BORANO EN UN SOLVENTE ORGANICO INERTE A LA TEMPERATURA DE REFLUJO DE LA MISMA, PARA OBTENER INDOLINAS DE FORMULA (I), DONDE N ES 1 A 3; R1 Y R2 SON H, HIDROXI, ALQUILO CON C 1 A 3 Y OTROS; Y R3 SON H O ALQUILO CON C 1 A 3.TIENEN APLICACION COMO AGENTES ANTIDEPRESIVOS EN ANIMALES DE SANGRE CALIENTE.
ES524479A 1982-07-28 1983-07-27 Procedimiento de preparacion de indolinas Granted ES524479A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US40249482A 1982-07-28 1982-07-28

Publications (2)

Publication Number Publication Date
ES8504125A1 true ES8504125A1 (es) 1985-04-01
ES524479A0 ES524479A0 (es) 1985-04-01

Family

ID=23592140

Family Applications (1)

Application Number Title Priority Date Filing Date
ES524479A Granted ES524479A0 (es) 1982-07-28 1983-07-27 Procedimiento de preparacion de indolinas

Country Status (14)

Country Link
EP (1) EP0100426A1 (es)
JP (1) JPS5933261A (es)
KR (1) KR840005424A (es)
AU (1) AU1734183A (es)
DK (1) DK344083A (es)
ES (1) ES524479A0 (es)
FI (1) FI832716A (es)
GR (1) GR77560B (es)
IL (1) IL69150A0 (es)
NO (1) NO832734L (es)
PH (1) PH18828A (es)
PL (1) PL243202A1 (es)
PT (1) PT77114B (es)
ZA (1) ZA835505B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2008107336A (ru) 2005-07-27 2009-09-10 Дов Фармасьютикал, Инк. (Us) Новые 1-арил-з-азабицикло{3.1.0.} гексаны: получение и применение для лечения психоневрологических расстройств
KR101294014B1 (ko) * 2006-01-06 2013-08-09 선오비온 파마슈티컬스 인코포레이티드 모노아민 재흡수 저해제로서의 시클로알킬아민
CA2746055C (en) * 2008-12-16 2016-12-13 Sunovion Pharmaceuticals Inc. Triple reuptake inhibitors and methods of their use
US20140206740A1 (en) 2011-07-30 2014-07-24 Neurovance, Inc. Use Of (1R,5S)-(+)-(Napthalen-2-yl)-3-Azabicyclo[3.1.0]Hexane In The Treatment Of Conditions Affected By Monoamine Neurotransmitters
US12110296B2 (en) * 2018-10-17 2024-10-08 N.E. Chemcat Corporation Compound, and method for producing the same

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2112548B1 (es) * 1970-11-09 1976-07-02 Eisai Co Ltd
US3917642A (en) * 1971-11-19 1975-11-04 Cities Service Co Brominated tricyclic imide flame retardants

Also Published As

Publication number Publication date
AU1734183A (en) 1984-02-02
ZA835505B (en) 1984-04-25
JPS5933261A (ja) 1984-02-23
KR840005424A (ko) 1984-11-12
PT77114B (en) 1986-01-27
FI832716A0 (fi) 1983-07-27
DK344083A (da) 1984-01-29
PH18828A (en) 1985-10-07
EP0100426A1 (en) 1984-02-15
DK344083D0 (da) 1983-07-27
GR77560B (es) 1984-09-24
PT77114A (en) 1983-08-01
ES524479A0 (es) 1985-04-01
PL243202A1 (en) 1985-07-02
IL69150A0 (en) 1983-11-30
FI832716A (fi) 1984-01-29
NO832734L (no) 1984-01-30

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