ES8407392A1 - Lymphocytes able to destroy cancer cells - Google Patents

Lymphocytes able to destroy cancer cells

Info

Publication number
ES8407392A1
ES8407392A1 ES523253A ES523253A ES8407392A1 ES 8407392 A1 ES8407392 A1 ES 8407392A1 ES 523253 A ES523253 A ES 523253A ES 523253 A ES523253 A ES 523253A ES 8407392 A1 ES8407392 A1 ES 8407392A1
Authority
ES
Spain
Prior art keywords
gra
lectin
cells
lymphocytes
cancer cells
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES523253A
Other languages
Spanish (es)
Other versions
ES523253A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Otsuka Pharmaceutical Co Ltd
Original Assignee
Otsuka Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56156413A external-priority patent/JPS5857318A/en
Priority claimed from JP15641481A external-priority patent/JPS5857321A/en
Priority claimed from JP56158472A external-priority patent/JPS5859922A/en
Priority claimed from JP56158473A external-priority patent/JPS5859923A/en
Application filed by Otsuka Pharmaceutical Co Ltd filed Critical Otsuka Pharmaceutical Co Ltd
Publication of ES523253A0 publication Critical patent/ES523253A0/en
Publication of ES8407392A1 publication Critical patent/ES8407392A1/en
Expired legal-status Critical Current

Links

Landscapes

  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Lymphocytes which are toxic to cancer cells and specific for a glyco-related antigen (GRA) of such cells are made by sensitising leucocytes to a GRA. Particularly the GRA is a component of cancer cell membranes and combines with a lectin specifically at the galactose or N-acetylgalactosamine terminal gp. GRA are isolated from human cancer cells by complexing with a lectin e.g. groundnut or soya lectin for glactose specificity, or Dolictios agglutinin or Luma bean lactin for N-acetylgalactosamine. Both types of lectin can be used to recover a single antigen. Also new are pharmaceutical compsns. contg. sensitised lymphocytes or GRA. Sensitised cells destroy cancer cells carrying the corresponding GRA and are specific since GRA do not occur on normal cells. They can be used in prevention or treatment of cancer.
ES523253A 1981-10-01 1983-06-14 Lymphocytes able to destroy cancer cells Expired ES8407392A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP56156413A JPS5857318A (en) 1981-10-01 1981-10-01 Production of lymphocytes inhibiting cancer cells
JP15641481A JPS5857321A (en) 1981-10-01 1981-10-01 Anticancer agent
JP56158472A JPS5859922A (en) 1981-10-05 1981-10-05 Cancer cell-disturbing lymphocyte
JP56158473A JPS5859923A (en) 1981-10-05 1981-10-05 Carcinostatic agent

Publications (2)

Publication Number Publication Date
ES523253A0 ES523253A0 (en) 1984-10-01
ES8407392A1 true ES8407392A1 (en) 1984-10-01

Family

ID=27473414

Family Applications (2)

Application Number Title Priority Date Filing Date
ES514450A Expired ES8402615A1 (en) 1981-10-01 1982-06-30 Lymphocytes able to destroy cancer cells
ES523253A Expired ES8407392A1 (en) 1981-10-01 1983-06-14 Lymphocytes able to destroy cancer cells

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES514450A Expired ES8402615A1 (en) 1981-10-01 1982-06-30 Lymphocytes able to destroy cancer cells

Country Status (3)

Country Link
CA (1) CA1201988A (en)
ES (2) ES8402615A1 (en)
PH (1) PH22474A (en)

Also Published As

Publication number Publication date
ES514450A0 (en) 1984-03-01
ES523253A0 (en) 1984-10-01
CA1201988A (en) 1986-03-18
ES8402615A1 (en) 1984-03-01
PH22474A (en) 1988-09-12

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