ES8407392A1 - Lymphocytes able to destroy cancer cells - Google Patents
Lymphocytes able to destroy cancer cellsInfo
- Publication number
- ES8407392A1 ES8407392A1 ES523253A ES523253A ES8407392A1 ES 8407392 A1 ES8407392 A1 ES 8407392A1 ES 523253 A ES523253 A ES 523253A ES 523253 A ES523253 A ES 523253A ES 8407392 A1 ES8407392 A1 ES 8407392A1
- Authority
- ES
- Spain
- Prior art keywords
- gra
- lectin
- cells
- lymphocytes
- cancer cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Lymphocytes which are toxic to cancer cells and specific for a glyco-related antigen (GRA) of such cells are made by sensitising leucocytes to a GRA. Particularly the GRA is a component of cancer cell membranes and combines with a lectin specifically at the galactose or N-acetylgalactosamine terminal gp. GRA are isolated from human cancer cells by complexing with a lectin e.g. groundnut or soya lectin for glactose specificity, or Dolictios agglutinin or Luma bean lactin for N-acetylgalactosamine. Both types of lectin can be used to recover a single antigen. Also new are pharmaceutical compsns. contg. sensitised lymphocytes or GRA. Sensitised cells destroy cancer cells carrying the corresponding GRA and are specific since GRA do not occur on normal cells. They can be used in prevention or treatment of cancer.
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP56156413A JPS5857318A (en) | 1981-10-01 | 1981-10-01 | Production of lymphocytes inhibiting cancer cells |
JP15641481A JPS5857321A (en) | 1981-10-01 | 1981-10-01 | Anticancer agent |
JP56158472A JPS5859922A (en) | 1981-10-05 | 1981-10-05 | Cancer cell-disturbing lymphocyte |
JP56158473A JPS5859923A (en) | 1981-10-05 | 1981-10-05 | Carcinostatic agent |
Publications (2)
Publication Number | Publication Date |
---|---|
ES523253A0 ES523253A0 (en) | 1984-10-01 |
ES8407392A1 true ES8407392A1 (en) | 1984-10-01 |
Family
ID=27473414
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514450A Expired ES8402615A1 (en) | 1981-10-01 | 1982-06-30 | Lymphocytes able to destroy cancer cells |
ES523253A Expired ES8407392A1 (en) | 1981-10-01 | 1983-06-14 | Lymphocytes able to destroy cancer cells |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES514450A Expired ES8402615A1 (en) | 1981-10-01 | 1982-06-30 | Lymphocytes able to destroy cancer cells |
Country Status (3)
Country | Link |
---|---|
CA (1) | CA1201988A (en) |
ES (2) | ES8402615A1 (en) |
PH (1) | PH22474A (en) |
-
1982
- 1982-06-30 ES ES514450A patent/ES8402615A1/en not_active Expired
- 1982-06-30 CA CA000406449A patent/CA1201988A/en not_active Expired
- 1982-06-30 PH PH27516A patent/PH22474A/en unknown
-
1983
- 1983-06-14 ES ES523253A patent/ES8407392A1/en not_active Expired
Also Published As
Publication number | Publication date |
---|---|
ES514450A0 (en) | 1984-03-01 |
ES523253A0 (en) | 1984-10-01 |
CA1201988A (en) | 1986-03-18 |
ES8402615A1 (en) | 1984-03-01 |
PH22474A (en) | 1988-09-12 |
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