ES8405024A1 - Tylosin derivs. - Google Patents

Tylosin derivs.

Info

Publication number
ES8405024A1
ES8405024A1 ES520905A ES520905A ES8405024A1 ES 8405024 A1 ES8405024 A1 ES 8405024A1 ES 520905 A ES520905 A ES 520905A ES 520905 A ES520905 A ES 520905A ES 8405024 A1 ES8405024 A1 ES 8405024A1
Authority
ES
Spain
Prior art keywords
alkyl
substd
opt
tylosin
epoxy
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES520905A
Other languages
Spanish (es)
Other versions
ES520905A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Microbial Chemistry Research Foundation
Original Assignee
Microbial Chemistry Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56107485A external-priority patent/JPS5815997A/en
Priority claimed from JP56154068A external-priority patent/JPS5855497A/en
Application filed by Microbial Chemistry Research Foundation filed Critical Microbial Chemistry Research Foundation
Publication of ES520905A0 publication Critical patent/ES520905A0/en
Publication of ES8405024A1 publication Critical patent/ES8405024A1/en
Expired legal-status Critical Current

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Tylosin derivs. of formula (I) are new. (R1 is OH, halogen, NR5R6, NX (opt. substd. by an oxo gp., OH, 1-6C alkyl or 1-6C hydroxyalkyl), or imidazolyl, morpholino or piperazino (each opt. substd. by 1-6C alkyl) or O-COCH2R8; R5 is H or 1-6C alkyl opt. substd. by a OH gp.; R6 is H, 1-6C alkyl opt. substd. by a OH gp., aryl, aralkyl, 3-10C cycloalkyl, CO(O)mR7 or CH2R13; m is 0 or 1; R7 is 1-6C alkyl, aryl, aralkyl, furaryl or pyridinyl; R13 is CH2F, CHF2 or CF3; X is (CH2)n; n is 2-15; R8 is NR9R10 or SR11; R9 and R10 are H or 1-6C alkyl; or R9 + R10 form 3-7C alkylene; R11 is furanyl or pyridinyl; R2 is H or 1-6C alkanoyl; R3 is Me or CH2CHO; R4 is H or OH; A is O, (alpha H, beta OH) or (alpha OH, beta H); the wavy line is a single or double bond; and the broken line is a single or double bond or an epoxy-bridged single bond. Provided that (1) when R1 is OH, R3 is Me and R4 is H, or the broken line is an epoxy-bridged single bond; and (2) when R1 is halogen, R3 is Me or the broken line is an epoxy-bridged bond). (I) are broad-spectrum antibacterials with greater activity then tylosin. Dose is 0.01-1 g administered 1-4 times daily.
ES520905A 1981-07-09 1983-03-23 Tylosin derivs. Expired ES8405024A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56107485A JPS5815997A (en) 1981-07-09 1981-07-09 Novel tylosin derivative
JP56154068A JPS5855497A (en) 1981-09-29 1981-09-29 Novel tylosin derivative

Publications (2)

Publication Number Publication Date
ES520905A0 ES520905A0 (en) 1984-05-16
ES8405024A1 true ES8405024A1 (en) 1984-05-16

Family

ID=26447514

Family Applications (1)

Application Number Title Priority Date Filing Date
ES520905A Expired ES8405024A1 (en) 1981-07-09 1983-03-23 Tylosin derivs.

Country Status (1)

Country Link
ES (1) ES8405024A1 (en)

Also Published As

Publication number Publication date
ES520905A0 (en) 1984-05-16

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