ES8402589A1 - 5,6,7,8-Tetrahydro-1,6 naphthyridine derivatives and their preparation - Google Patents
5,6,7,8-Tetrahydro-1,6 naphthyridine derivatives and their preparationInfo
- Publication number
- ES8402589A1 ES8402589A1 ES516935A ES516935A ES8402589A1 ES 8402589 A1 ES8402589 A1 ES 8402589A1 ES 516935 A ES516935 A ES 516935A ES 516935 A ES516935 A ES 516935A ES 8402589 A1 ES8402589 A1 ES 8402589A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- lower alkyl
- hydrogen
- piperazinyl
- piperidinyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- FPEAARFNXIWCTP-UHFFFAOYSA-N 5,6,7,8-tetrahydro-1,6-naphthyridine Chemical class C1=CC=C2CNCCC2=N1 FPEAARFNXIWCTP-UHFFFAOYSA-N 0.000 title abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 4
- 239000001257 hydrogen Substances 0.000 abstract 4
- -1 4-hydroxy-4-phenyl-1-piperidinyl Chemical group 0.000 abstract 3
- 229910052736 halogen Chemical group 0.000 abstract 3
- 150000002367 halogens Chemical group 0.000 abstract 3
- 125000003545 alkoxy group Chemical group 0.000 abstract 2
- 125000002947 alkylene group Chemical group 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 125000004214 1-pyrrolidinyl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000012886 Vertigo Diseases 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 150000002431 hydrogen Chemical group 0.000 abstract 1
- 125000005322 morpholin-1-yl group Chemical group 0.000 abstract 1
- 239000003158 myorelaxant agent Substances 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000004193 piperazinyl group Chemical group 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 231100000889 vertigo Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/185—Radicals derived from carboxylic acids from aliphatic carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/36—Radicals substituted by singly-bound nitrogen atoms
- C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
5,6,7,8-Tetrahydro-1,6-naphthyridine derivatives for use in treating vertigo and as a central muscle relaxant have the general formula < IMAGE > wherein R1 and R2 are each hydrogen or a lower alkyl group or R1 and R2 are bonded together to form an alkylene group with 2 to 5 carbon atoms, R3 is hydrogen, a lower alkyl group, benzyl group or a phenyl group represented by the formula < IMAGE > in which R4 is hydrogen or halogen or a lower alkyl or lower alkoxy group, A is a linear or branched alkylene group with 2 to 4 carbon atoms, and Y is a diloweralkylamino 1-pyrrolidinyl, 1-loweralkylpyrrolidinyl, 1 -piperidinyl, 4-hydroxy-4-phenyl-1-piperidinyl, 4-hydroxy-4-(halogenphenyl)-1 -piperidinyl, 1-morpholinyl, 4-loweralkyl-1-piperazinyl, 4-benzyl-1 -piperazinyl, 4-pyridyl-1-piperazinyl group or a piperazinyl group represented by the formula < IMAGE > in which R5 is hydrogen or halogen, a lower alkyl, halogen substituted lower alkyl or lower alkoxy group. These compounds can be in the form of their non-toxic salts.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP55150719A JPS5775983A (en) | 1980-10-29 | 1980-10-29 | Novel derivative of 5,6,7,-tetrahydro-2,6-naphthyridine and its preparation |
| JP56154863A JPS5857379A (en) | 1981-10-01 | 1981-10-01 | 5,6,7,8-tetrahydro-1,6-naphthyridine derivative and its preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| ES516935A0 ES516935A0 (en) | 1984-02-16 |
| ES8402589A1 true ES8402589A1 (en) | 1984-02-16 |
Family
ID=26480230
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES516935A Expired ES8402589A1 (en) | 1980-10-29 | 1982-10-15 | 5,6,7,8-Tetrahydro-1,6 naphthyridine derivatives and their preparation |
Country Status (4)
| Country | Link |
|---|---|
| DE (1) | DE3143016A1 (en) |
| ES (1) | ES8402589A1 (en) |
| GB (1) | GB2087390B (en) |
| IT (1) | IT8124760A0 (en) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6294547B1 (en) * | 1997-06-30 | 2001-09-25 | Nippon Kayaku Kabushiki Kaisha | Naphthyridine deratives or salts thereof |
| US6433174B1 (en) * | 1998-12-16 | 2002-08-13 | Nippon Kayaku Kabushiki Kaisha | Process for producing novel naphthyridine derivatives |
| EP1848430B1 (en) * | 2004-12-31 | 2017-08-02 | Dr. Reddy's Laboratories Ltd. | Novel benzylamine derivatives as cetp inhibitors |
| US8604055B2 (en) | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
| WO2013024358A2 (en) | 2011-08-18 | 2013-02-21 | Dr. Reddy's Laboratories Ltd. | Substituted heterocyclic amine compounds as cholestryl ester-transfer protein (cetp) inhibitors |
| IN2014CN02290A (en) | 2011-09-27 | 2015-06-19 | Reddys Lab Ltd Dr |
-
1981
- 1981-10-29 GB GB8132554A patent/GB2087390B/en not_active Expired
- 1981-10-29 DE DE19813143016 patent/DE3143016A1/en not_active Withdrawn
- 1981-10-29 IT IT8124760A patent/IT8124760A0/en unknown
-
1982
- 1982-10-15 ES ES516935A patent/ES8402589A1/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DE3143016A1 (en) | 1982-05-27 |
| ES516935A0 (en) | 1984-02-16 |
| IT8124760A0 (en) | 1981-10-29 |
| GB2087390A (en) | 1982-05-26 |
| GB2087390B (en) | 1984-06-13 |
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