ES8308879A1 - Un procedimiento para la preparacion de nuevos derivados bencilicos trisustituidos - Google Patents

Un procedimiento para la preparacion de nuevos derivados bencilicos trisustituidos

Info

Publication number
ES8308879A1
ES8308879A1 ES515988A ES515988A ES8308879A1 ES 8308879 A1 ES8308879 A1 ES 8308879A1 ES 515988 A ES515988 A ES 515988A ES 515988 A ES515988 A ES 515988A ES 8308879 A1 ES8308879 A1 ES 8308879A1
Authority
ES
Spain
Prior art keywords
alkyl
group
preparation
pharmaceutical composition
composition containing
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515988A
Other languages
English (en)
Other versions
ES515988A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beecham Group PLC
Original Assignee
Beecham Group PLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beecham Group PLC filed Critical Beecham Group PLC
Publication of ES8308879A1 publication Critical patent/ES8308879A1/es
Publication of ES515988A0 publication Critical patent/ES515988A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
    • C07D513/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS BENCILICOS TRISUSTITUIDOS, DE SUS SALES FISIOLOGICAMENTE COMPATIBLES Y DE SUS SOLVATOS, DE FORMULA (I), EN LA QUE A, R<1 Y R<2 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE REDUCCION DE UN COMPUESTO DE FORMULA (I), EN LA QUE R<1<0 ES HIDROXILO O HIDROXILO PROTEGIDO; Y R<1<1 Y R<3 PUEDEN SER VARIOS TIPOS DE RADIALES; SEGUIDA DE LA EVENTUAL TRANSFORMACION DE R<1<0 O R<1<1 EN R<1 O R<2. LA REDUCCION SE LLEVA A CABO POR HIDROGENACION EN PRESENCIA DE UN CATALIZADOR DE OXIDO DE PLATINO O DE RODIO A LA PRESION ATMOSFERICA O LIGERAMENTE SUPERIOR, EN UN DISOLVENTE POLAR INERTE, A LA TEMPERATURA AMBIENTE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LOS TRASTORNOS DEL SISTEMA NERVIOSO CENTRAL RELACIONADOS CON UN EXCESO DE LIBERACION DE DOPAMINA.
ES515988A 1981-09-28 1982-09-27 Un procedimiento para la preparacion de nuevos derivados bencilicos trisustituidos Granted ES515988A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB8129282 1981-09-28
GB8135161 1981-11-21

Publications (2)

Publication Number Publication Date
ES8308879A1 true ES8308879A1 (es) 1983-10-01
ES515988A0 ES515988A0 (es) 1983-10-01

Family

ID=26280830

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515988A Granted ES515988A0 (es) 1981-09-28 1982-09-27 Un procedimiento para la preparacion de nuevos derivados bencilicos trisustituidos

Country Status (3)

Country Link
EP (1) EP0076089A3 (es)
AU (1) AU8872482A (es)
ES (1) ES515988A0 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4895943A (en) * 1988-10-25 1990-01-23 Pfizer Inc. Preparation of 1,4-diazabicyclo(3.2.2)nonane
CA1321751C (en) * 1989-02-21 1993-08-31 Eugene C. Crichlow Mechanism mediating ruminal stasis in ruminal lactic acidosis
EP0398578B1 (en) * 1989-05-17 1997-03-12 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents
EP0629190A1 (en) * 1992-01-28 1994-12-21 Smithkline Beecham Plc Compounds as calcium channel antagonists
US5288872A (en) * 1992-03-13 1994-02-22 Wake Forest University Compounds for treatment of neurodegenerative diseases
US5227385A (en) * 1992-03-13 1993-07-13 Wake Forest University Method for treatment of neurodegenerative diseases
EP1318988A2 (en) 2000-09-11 2003-06-18 Sepracor, Inc. Ligands for monoamine receptors and transporters, and methods of use thereof (neurotransmission)
US7294637B2 (en) 2000-09-11 2007-11-13 Sepracor, Inc. Method of treating addiction or dependence using a ligand for a monamine receptor or transporter

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH433359A (de) * 1962-11-13 1967-04-15 Boehringer & Soehne Gmbh Verfahren zur Herstellung neuer 3a-Phenyl-granatan-Derivate
US3509161A (en) * 1967-07-10 1970-04-28 Boehringer & Soehne Gmbh 3-phenyl-granatene-(2)-derivatives
US4180669A (en) * 1976-12-13 1979-12-25 Abbott Laboratories 2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol

Also Published As

Publication number Publication date
EP0076089A2 (en) 1983-04-06
AU8872482A (en) 1983-04-14
EP0076089A3 (en) 1983-05-25
ES515988A0 (es) 1983-10-01

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