ES8306729A1 - Novel 2-isopropyl-pyrido[2,1-b]quinazolines and their non-toxic salts, process for their preparation and pharmaceutical compositions containing these compounds - Google Patents
Novel 2-isopropyl-pyrido[2,1-b]quinazolines and their non-toxic salts, process for their preparation and pharmaceutical compositions containing these compoundsInfo
- Publication number
- ES8306729A1 ES8306729A1 ES511866A ES511866A ES8306729A1 ES 8306729 A1 ES8306729 A1 ES 8306729A1 ES 511866 A ES511866 A ES 511866A ES 511866 A ES511866 A ES 511866A ES 8306729 A1 ES8306729 A1 ES 8306729A1
- Authority
- ES
- Spain
- Prior art keywords
- quinazolines
- novel
- pharmaceutical compositions
- pyrido
- isopropyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- OWMJIRZHTRAWQP-UHFFFAOYSA-N 2-propan-2-yl-9H-pyrido[2,1-b]quinazoline Chemical class C(C)(C)C1=CC2=CN3C(N=C2C=C1)=CC=CC3 OWMJIRZHTRAWQP-UHFFFAOYSA-N 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
- 231100000252 nontoxic Toxicity 0.000 title 1
- 230000003000 nontoxic effect Effects 0.000 title 1
- 150000003839 salts Chemical class 0.000 title 1
- 125000002294 quinazolinyl group Chemical class N1=C(N=CC2=CC=CC=C12)* 0.000 abstract 2
- QWNMKHLBVHTPFW-UHFFFAOYSA-N 2-amino-5-propan-2-ylbenzoic acid Chemical compound CC(C)C1=CC=C(N)C(C(O)=O)=C1 QWNMKHLBVHTPFW-UHFFFAOYSA-N 0.000 abstract 1
- UAWMVMPAYRWUFX-UHFFFAOYSA-N 6-Chloronicotinic acid Chemical compound OC(=O)C1=CC=C(Cl)N=C1 UAWMVMPAYRWUFX-UHFFFAOYSA-N 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Abstract
The novel quinazolines correspond to the general formula below < IMAGE > in which the radical R represents a carboxyl, carboxamide, cyano or tetrazolyl radical. They are prepared by reaction of 5-isopropylanthranilic acid with 6-chloronicotinic acid. These novel quinazolines form the active constitutent of pharmaceutical compositions which can be administered orally.
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES511866A ES8306729A1 (en) | 1982-04-30 | 1982-04-30 | Novel 2-isopropyl-pyrido[2,1-b]quinazolines and their non-toxic salts, process for their preparation and pharmaceutical compositions containing these compounds |
IT67457/83A IT1160121B (en) | 1982-04-30 | 1983-04-28 | COMPOUND 2 ISOPROPYLPYRID 2 1 B CHINAZOLINE ITS NON-TOXIC SALTS WITH ANTIANAPYLACTIC ACTIVITY AND PROCEDURE FOR THEIR PREPARATION |
DE19833315471 DE3315471A1 (en) | 1982-04-30 | 1983-04-28 | Novel 2-isopropyl-pyrido[2,1-b]quinazolines and their non-toxic salts, process for their preparation and pharmaceutical compositions containing these compounds |
FR8307202A FR2526023B1 (en) | 1982-04-30 | 1983-04-29 | NOVEL 2-ISOPROPYL PYRIDO (2-1-B) QUINAZOLINES AND THEIR NON-TOXIC SALTS, PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
BE0/215100A BE902544Q (en) | 1982-04-30 | 1985-05-30 | NOVELS 2-ISOPROPYL PYRIDO (2-1-b) QUINAZOLINE AND THEIR NON-TOXIC SALTS PROCESS FOR PRODUCING THE SAME AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ES511866A ES8306729A1 (en) | 1982-04-30 | 1982-04-30 | Novel 2-isopropyl-pyrido[2,1-b]quinazolines and their non-toxic salts, process for their preparation and pharmaceutical compositions containing these compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
ES511866A0 ES511866A0 (en) | 1983-06-01 |
ES8306729A1 true ES8306729A1 (en) | 1983-06-01 |
Family
ID=8484086
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES511866A Expired ES8306729A1 (en) | 1982-04-30 | 1982-04-30 | Novel 2-isopropyl-pyrido[2,1-b]quinazolines and their non-toxic salts, process for their preparation and pharmaceutical compositions containing these compounds |
Country Status (5)
Country | Link |
---|---|
BE (1) | BE902544Q (en) |
DE (1) | DE3315471A1 (en) |
ES (1) | ES8306729A1 (en) |
FR (1) | FR2526023B1 (en) |
IT (1) | IT1160121B (en) |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NZ186759A (en) * | 1977-03-24 | 1981-03-16 | Hoffmann La Roche | 11h-pyrido(2,1-b)quinazolin-11-ones |
-
1982
- 1982-04-30 ES ES511866A patent/ES8306729A1/en not_active Expired
-
1983
- 1983-04-28 DE DE19833315471 patent/DE3315471A1/en not_active Ceased
- 1983-04-28 IT IT67457/83A patent/IT1160121B/en active
- 1983-04-29 FR FR8307202A patent/FR2526023B1/en not_active Expired
-
1985
- 1985-05-30 BE BE0/215100A patent/BE902544Q/en not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DE3315471A1 (en) | 1983-12-01 |
ES511866A0 (en) | 1983-06-01 |
BE902544Q (en) | 1985-09-16 |
IT8367457A0 (en) | 1983-04-28 |
FR2526023A1 (en) | 1983-11-04 |
IT1160121B (en) | 1987-03-04 |
FR2526023B1 (en) | 1986-10-03 |
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