ES8305747A1 - Procedimiento para la obtencion de derivados del acido 1,2,5-oxadiazol-3,4-dicarboxilico. - Google Patents

Procedimiento para la obtencion de derivados del acido 1,2,5-oxadiazol-3,4-dicarboxilico.

Info

Publication number
ES8305747A1
ES8305747A1 ES515446A ES515446A ES8305747A1 ES 8305747 A1 ES8305747 A1 ES 8305747A1 ES 515446 A ES515446 A ES 515446A ES 515446 A ES515446 A ES 515446A ES 8305747 A1 ES8305747 A1 ES 8305747A1
Authority
ES
Spain
Prior art keywords
group
oxadiazole
moles
atoms
image
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES515446A
Other languages
English (en)
Other versions
ES515446A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Cassella Farbwerke Mainkur AG
Original Assignee
Cassella AG
Cassella Farbwerke Mainkur AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cassella AG, Cassella Farbwerke Mainkur AG filed Critical Cassella AG
Publication of ES8305747A1 publication Critical patent/ES8305747A1/es
Publication of ES515446A0 publication Critical patent/ES515446A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
    • C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
    • C07D271/08—1,2,5-Oxadiazoles; Hydrogenated 1,2,5-oxadiazoles

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DEL ACIDO 1,2,5-OXADIAZOL-3,4-DICARBOXILICO Y DE SUS COMPUESTOS DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I), EN LA QUE R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE UN ESTER DE ACIDO 1,2,5-OXADIAZOL-3,4-BIS-CARBOXILICO, DE FORMULA (II) CON UNA AMINA DE FORMULA R NH O R R NH, EN LAS QUE R ES ALQUILO C <- , Y R , R Y R PUEDEN SER VARIOS TIPOS DE RADICALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE O DISPERSANTE ADECUADO, O MEZCLAS DE LOS MISMOS, A UNA TEMPERATURA COMPRENDIDA ENTRE -10 C Y 120 C. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE ELEVADA PRESION SANGUINEA Y DE LA ANGINA DE PECHO.
ES515446A 1981-09-03 1982-09-02 Procedimiento para la obtencion de derivados del acido 1,2,5-oxadiazol-3,4-dicarboxilico. Granted ES515446A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19813134849 DE3134849A1 (de) 1981-09-03 1981-09-03 1,2,5-oxadiazol-3,4-dicarbonsaeurederivate, verfahren zu ihrer herstellung, ihre verwendung und sie enthaltende pharmazeutische zubereitungen

Publications (2)

Publication Number Publication Date
ES8305747A1 true ES8305747A1 (es) 1983-05-01
ES515446A0 ES515446A0 (es) 1983-05-01

Family

ID=6140748

Family Applications (1)

Application Number Title Priority Date Filing Date
ES515446A Granted ES515446A0 (es) 1981-09-03 1982-09-02 Procedimiento para la obtencion de derivados del acido 1,2,5-oxadiazol-3,4-dicarboxilico.

Country Status (6)

Country Link
EP (1) EP0075141A1 (es)
JP (1) JPS5852279A (es)
DD (1) DD209195A5 (es)
DE (1) DE3134849A1 (es)
ES (1) ES515446A0 (es)
SU (1) SU1138026A3 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4217794A1 (de) * 1992-05-29 1993-12-02 Cassella Ag Phenylfuroxane
DE4218582A1 (de) * 1992-06-05 1993-12-09 Cassella Ag Pyridyl-1,2,5-oxadiazol-carbonamid-2-oxide
DE4220264A1 (de) * 1992-06-20 1993-12-23 Cassella Ag Phenyl-1,2,5-oxadiazol-carbonamid-2-oxide
RU2489428C1 (ru) * 2012-02-21 2013-08-10 Федеральное государственное унитарное предприятие "Специальное конструкторско-технологическое бюро "Технолог" Способ получения 3, 4-бис(3-аминофуразан-4-ил)-фуразана и его n, n'-диацильных производных
JP6569341B2 (ja) * 2015-07-10 2019-09-04 住友化学株式会社 ２−ハロアセト酢酸アミドの製造方法
CN114105900B (zh) * 2021-11-25 2023-07-11 浙江工业大学 一种3,4-二苯甲酮-1,2,5-恶二唑的制备方法

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3012862A1 (de) * 1980-04-02 1981-10-08 Cassella Ag, 6000 Frankfurt Substituierte 1,2,5-oxdiazol-2-oxide als pharmazeutische wirkstoffe, ihre verwendung und sie enthaltende arzneimittel

Also Published As

Publication number Publication date
SU1138026A3 (ru) 1985-01-30
JPS5852279A (ja) 1983-03-28
DD209195A5 (de) 1984-04-25
EP0075141A1 (de) 1983-03-30
DE3134849A1 (de) 1983-03-10
ES515446A0 (es) 1983-05-01

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