ES8303399A1 - "un metodo para preparar una 2-(piridilbutilamino)-pirimidona". - Google Patents

"un metodo para preparar una 2-(piridilbutilamino)-pirimidona".

Info

Publication number
ES8303399A1
ES8303399A1 ES512426A ES512426A ES8303399A1 ES 8303399 A1 ES8303399 A1 ES 8303399A1 ES 512426 A ES512426 A ES 512426A ES 512426 A ES512426 A ES 512426A ES 8303399 A1 ES8303399 A1 ES 8303399A1
Authority
ES
Spain
Prior art keywords
pyridyl
chemical process
methoxy
methyl
yrimid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512426A
Other languages
English (en)
Other versions
ES512426A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
SmithKline Beecham Corp
Original Assignee
SmithKline Beecham Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by SmithKline Beecham Corp filed Critical SmithKline Beecham Corp
Publication of ES512426A0 publication Critical patent/ES512426A0/es
Publication of ES8303399A1 publication Critical patent/ES8303399A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
    • C07D213/63—One oxygen atom
    • C07D213/65—One oxygen atom attached in position 3 or 5

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Peptides Or Proteins (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE 2-(PIRIDILBUTILAMINO)-PIRIMIDONA, DE FORMULA (I), Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES. CONSISTE EN LA REACCION DE UNA GUANIDINA DE FORMULA (II), CON UN 2-FORMIL-3-PIRIDINIL PROPIONATO, DE FORMULA (III), EN LA QUE ALK ES ALCOHILO INFERIOR C <- . LA REACCION SE LLEVA A CABO EN EL SISTEMA DISOLVENTE AGUA/HIDROCARBURO HALOGENADO, EN MEDIO NEUTRO O DEBILMENTE BASICO, EN PRESENCIA DE UN AGENTE DE TRANSFERENCIA DE FASE. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD DE BLOQUEO DEL RECEPTOR H DE LA HISTAMINA.
ES512426A 1981-05-27 1982-05-21 "un metodo para preparar una 2-(piridilbutilamino)-pirimidona". Expired ES8303399A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB8116156 1981-05-27

Publications (2)

Publication Number Publication Date
ES512426A0 ES512426A0 (es) 1983-02-01
ES8303399A1 true ES8303399A1 (es) 1983-02-01

Family

ID=10522080

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512426A Expired ES8303399A1 (es) 1981-05-27 1982-05-21 "un metodo para preparar una 2-(piridilbutilamino)-pirimidona".

Country Status (11)

Country Link
EP (1) EP0066442B1 (es)
JP (1) JPS57200365A (es)
AT (1) ATE14581T1 (es)
AU (1) AU548256B2 (es)
DE (1) DE3265063D1 (es)
DK (1) DK234982A (es)
ES (1) ES8303399A1 (es)
GR (1) GR75490B (es)
IE (1) IE52967B1 (es)
PT (1) PT74865B (es)
ZA (1) ZA823607B (es)

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1564502A (en) * 1975-07-31 1980-04-10 Smith Kline French Lab Guanidines thioureas and 1,1-diamino-2-nitroethylene derivatives
US4154834A (en) * 1975-12-29 1979-05-15 Smith Kline & French Laboratories Limited Substituted isocytosines having histamine H2 -antagonist activity
PH16240A (en) * 1978-04-11 1983-08-11 Smith Kline French Lab Process for making histamine antagonist
AU531142B2 (en) * 1979-04-04 1983-08-11 Smith Kline & French Laboratories Limited 2 amino- pyimindones
ZW21281A1 (en) * 1980-10-01 1981-11-18 Smith Kline French Lab Amine derivatives

Also Published As

Publication number Publication date
EP0066442A1 (en) 1982-12-08
IE52967B1 (en) 1988-04-27
JPS57200365A (en) 1982-12-08
ES512426A0 (es) 1983-02-01
AU8410382A (en) 1982-12-02
PT74865B (en) 1983-12-07
IE821263L (en) 1982-11-27
ATE14581T1 (de) 1985-08-15
DE3265063D1 (en) 1985-09-05
GR75490B (es) 1984-07-23
AU548256B2 (en) 1985-12-05
EP0066442B1 (en) 1985-07-31
PT74865A (en) 1982-06-01
DK234982A (da) 1982-11-28
ZA823607B (en) 1983-03-30

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