ES8303288A1 - Procedure for obtaining N- (trans-4-hydroxy-cycle-hexil -) - (2-amino-3,5-dibrome) benzylamine and its pharmaceutically acceptable salts. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for obtaining N- (trans-4-hydroxy-cycle-hexil -) - (2-amino-3,5-dibrome) benzylamine and its pharmaceutically acceptable salts. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES8303288A1
ES8303288A1 ES507000A ES507000A ES8303288A1 ES 8303288 A1 ES8303288 A1 ES 8303288A1 ES 507000 A ES507000 A ES 507000A ES 507000 A ES507000 A ES 507000A ES 8303288 A1 ES8303288 A1 ES 8303288A1
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ES
Spain
Prior art keywords
amino
trans
obtaining
benzylamine
translation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES507000A
Other languages
Spanish (es)
Other versions
ES507000A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Invest Farmaceutica S A Centro
Original Assignee
Invest Farmaceutica S A Centro
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Invest Farmaceutica S A Centro filed Critical Invest Farmaceutica S A Centro
Priority to ES507000A priority Critical patent/ES507000A0/en
Publication of ES8303288A1 publication Critical patent/ES8303288A1/en
Publication of ES507000A0 publication Critical patent/ES507000A0/en
Granted legal-status Critical Current

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Abstract

Procedure for the obtaining of N- (trans-4-hydroxy-ciclohexil) - (2-amino-3,5-dibromo) benzylamine and its pharmaceutically acceptable salts. Essentially in the formation of an imina through the condensation reaction of the carbonyl group of 2-amino-3,5-dibromobenzaldehido and of the amino group of trans-4-aminocicloexanol, followed by the reduction of such compound. The above condensation reaction is performed at low temperature and in organic environment, using preferently aromatic solvents. For the obtaining of the corresponding salts, inorganic acids are used preferably. Of application in the treatment of affections, by its bronchosecretaliticas properties. (Machine-translation by Google Translate, not legally binding)
ES507000A 1981-11-11 1981-11-11 PROCEDURE FOR OBTAINING N- (TRANS-4-HIDROXI-CICLO- HEXIL -) - (2-AMINO-3,5-DIBROMO) BENCILAMINE AND ITS PHARMA- CEUTICALLY ACCEPTABLE SALTS. Granted ES507000A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES507000A ES507000A0 (en) 1981-11-11 1981-11-11 PROCEDURE FOR OBTAINING N- (TRANS-4-HIDROXI-CICLO- HEXIL -) - (2-AMINO-3,5-DIBROMO) BENCILAMINE AND ITS PHARMA- CEUTICALLY ACCEPTABLE SALTS.

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES507000A ES507000A0 (en) 1981-11-11 1981-11-11 PROCEDURE FOR OBTAINING N- (TRANS-4-HIDROXI-CICLO- HEXIL -) - (2-AMINO-3,5-DIBROMO) BENCILAMINE AND ITS PHARMA- CEUTICALLY ACCEPTABLE SALTS.

Publications (2)

Publication Number Publication Date
ES8303288A1 true ES8303288A1 (en) 1983-02-01
ES507000A0 ES507000A0 (en) 1983-02-01

Family

ID=8483196

Family Applications (1)

Application Number Title Priority Date Filing Date
ES507000A Granted ES507000A0 (en) 1981-11-11 1981-11-11 PROCEDURE FOR OBTAINING N- (TRANS-4-HIDROXI-CICLO- HEXIL -) - (2-AMINO-3,5-DIBROMO) BENCILAMINE AND ITS PHARMA- CEUTICALLY ACCEPTABLE SALTS.

Country Status (1)

Country Link
ES (1) ES507000A0 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012167A (en) * 2012-12-16 2013-04-03 石药集团中诺药业（石家庄）有限公司 Preparation method of ambroxol hydrochloride

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107488119A (en) * 2016-06-13 2017-12-19 张家港市锦丰润尔发五金塑料厂 The dibromo N of 2 amino 3,5（Anti- 4 hydroxyl ring ethyl）The preparation method of benzylamine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103012167A (en) * 2012-12-16 2013-04-03 石药集团中诺药业（石家庄）有限公司 Preparation method of ambroxol hydrochloride

Also Published As

Publication number Publication date
ES507000A0 (en) 1983-02-01

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