Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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STWB Inc
Original Assignee
Sterling Drug Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/135,100external-prioritypatent/US4297360A/en
Priority claimed from US06/198,461external-prioritypatent/US4313951A/en
Application filed by Sterling Drug IncfiledCriticalSterling Drug Inc
Publication of ES8302661A1publicationCriticalpatent/ES8302661A1/en
Publication of ES497110A0publicationCriticalpatent/ES497110A0/en
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
Procedure for the obtaining of 2 (1H) -piridines, as well as their salts of addition of acid or cationic salts, of formula (I), in which r is lower rent; py 4-, 3- o 2-pyridinyl substituted or non-substitute; and q and r can be various types of radicals. It consists in the reaction of a compound of formula (II), in which r and r are lower rent, with malonamide to obtain a compound in which q is carbamilo, or with N-r - α -cianoacetamide if q is cyan. The reaction is carried out by heating the reagents to the reflow temperature in an inert solvent, in the presence of a basic condensation agent, such as a lower alcohol. These compounds have pharmacological applications as cardiotonic agents. (Machine-translation by Google Translate, not legally binding)
ES80497110A1980-03-281980-11-25
A PROCEDURE FOR PREPARING A 2 (1H) -PYRIDINONE
GrantedES497110A0
(en)
5-(Pyridinyl)-6-(lower-alkyl)-2(1H)-pyridinones, 1,2-dihydro-2-oxo-5-(pyridinyl)-6-(lower-alkyl)nicotinic acids and lower-alkyl esters thereof, and cardiotonic use thereof