ES8207524A2 - By procedure for the preparation of 4-hydroxy-tetrahydropyran-2-ona derivatives (Machine-translation by Google Translate, not legally binding) - Google Patents

By procedure for the preparation of 4-hydroxy-tetrahydropyran-2-ona derivatives (Machine-translation by Google Translate, not legally binding)

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Publication number
ES8207524A2
ES8207524A2 ES503916A ES503916A ES8207524A2 ES 8207524 A2 ES8207524 A2 ES 8207524A2 ES 503916 A ES503916 A ES 503916A ES 503916 A ES503916 A ES 503916A ES 8207524 A2 ES8207524 A2 ES 8207524A2
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ES
Spain
Prior art keywords
translation
procedure
preparation
machine
legally binding
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES503916A
Other languages
Spanish (es)
Other versions
ES503916A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority to ES503916A priority Critical patent/ES503916A0/en
Publication of ES8207524A2 publication Critical patent/ES8207524A2/en
Publication of ES503916A0 publication Critical patent/ES503916A0/en
Granted legal-status Critical Current

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Abstract

Improvements introduced in the proceeding of the main patent number 494.301, by: a procedure for the preparation of derivatives of 4-hydroxytetrahydropyran-2-ona. The modifications are characterized by: 1. Condensing the dianion of an acetoactic ether with a general formula aldehyde (I) to obtain compound (II). 2. Reduce the ceto group to a hydroxyl group. 3. Saponificate the ester, lactonize and separate the cis and trans racematos. 4. Form diasteromeric x-methylbencilamids of trasn-racemato and separate diasteromeros. 5. Hydrolyze the diastereiomer that contains the product (I) - trans-enantiomero and lactonizar. (Machine-translation by Google Translate, not legally binding)
ES503916A 1981-07-13 1981-07-13 BY PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-HYDROXY-TETRAHIDROPIRAN-2-ONA Granted ES503916A0 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES503916A ES503916A0 (en) 1981-07-13 1981-07-13 BY PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-HYDROXY-TETRAHIDROPIRAN-2-ONA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES503916A ES503916A0 (en) 1981-07-13 1981-07-13 BY PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-HYDROXY-TETRAHIDROPIRAN-2-ONA

Publications (2)

Publication Number Publication Date
ES8207524A2 true ES8207524A2 (en) 1982-10-01
ES503916A0 ES503916A0 (en) 1982-10-01

Family

ID=8482688

Family Applications (1)

Application Number Title Priority Date Filing Date
ES503916A Granted ES503916A0 (en) 1981-07-13 1981-07-13 BY PROCEDURE FOR THE PREPARATION OF DERIVATIVES OF 4-HYDROXY-TETRAHIDROPIRAN-2-ONA

Country Status (1)

Country Link
ES (1) ES503916A0 (en)

Also Published As

Publication number Publication date
ES503916A0 (en) 1982-10-01

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Effective date: 20170710