ES8205410A1 - Pyrazolopyridinones and Pyridinylnicotinates - Google Patents
Pyrazolopyridinones and PyridinylnicotinatesInfo
- Publication number
- ES8205410A1 ES8205410A1 ES500395A ES500395A ES8205410A1 ES 8205410 A1 ES8205410 A1 ES 8205410A1 ES 500395 A ES500395 A ES 500395A ES 500395 A ES500395 A ES 500395A ES 8205410 A1 ES8205410 A1 ES 8205410A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- halo
- addition salts
- pyridinylnicotinates
- pyrazolopyridinones
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/53—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
- C07D213/46—Oxygen atoms
- C07D213/50—Ketonic radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/80—Acids; Esters in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/84—Nitriles
- C07D213/85—Nitriles in position 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
Abstract
1,2-Dihydro-1-R-5-PY-6-Q-3H- pyrazoloÄ3,4-bÜpyridin-3-ones of the general formula I: < IMAGE > (R=alkyl, hydroxyalkyl, 2,3- dihodroxypropyl, alkoxyalkyl Q=H, alkyl PY=3- or 4-pyridyl optionally bearing one or two alkyl substituents) and acid-addition salts thereof, which are cardiotonic agents, are prepared by reacting an alkyl 2-halo-5-PY-6-Q- nicotinate with 1-R-hydrazine. The alkyl 2-halo-5-PY-6-Q-nicotinates and acid addition salts thereof are intermediates or cardiotonics.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US06/130,628 US4264612A (en) | 1980-03-17 | 1980-03-17 | Lower-alkyl 2-halo-5-(pyridinyl)nicotinates, their preparation and use as cardiotonics |
US06/130,623 US4265895A (en) | 1980-03-17 | 1980-03-17 | 1,2-Dihydro-5-pyridinyl-3H-pyrazolo[3,4-b]pyridin-3-ones and their use as cardiotonics |
Publications (2)
Publication Number | Publication Date |
---|---|
ES8205410A1 true ES8205410A1 (en) | 1982-06-01 |
ES500395A0 ES500395A0 (en) | 1982-06-01 |
Family
ID=26828659
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES500395A Granted ES500395A0 (en) | 1980-03-17 | 1981-03-16 | A PROCEDURE FOR PREPARING A PIRAZOLO-PIRIDINONE |
Country Status (16)
Country | Link |
---|---|
AU (1) | AU6813881A (en) |
DE (1) | DE3110313A1 (en) |
DK (1) | DK117081A (en) |
ES (1) | ES500395A0 (en) |
FI (1) | FI810779L (en) |
FR (1) | FR2478098A1 (en) |
GB (1) | GB2073179A (en) |
IL (1) | IL62306A0 (en) |
IT (1) | IT1141999B (en) |
LU (1) | LU83221A1 (en) |
NL (1) | NL8101269A (en) |
NO (1) | NO810833L (en) |
NZ (1) | NZ196453A (en) |
PH (1) | PH15978A (en) |
PT (1) | PT72674B (en) |
SE (1) | SE8101592L (en) |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2953571A (en) * | 1957-12-13 | 1960-09-20 | Gen Aniline & Film Corp | Pyrazolopyridines |
AU454992B2 (en) * | 1970-06-03 | 1974-10-28 | Euclid Inc | Exhaust diverting valve for dumpable vehicles having heated dump bodies |
DE2232038A1 (en) * | 1972-06-30 | 1974-01-10 | Hoechst Ag | 3-AMINO-1H-PYRAZOLO SQUARE CLAMP ON 3.4-ANGLE BRACKET FOR PYRIDINE, THEIR PRODUCTION AND USE |
US4081451A (en) * | 1975-03-20 | 1978-03-28 | Schering Corporation | Process for preparing 2-halogeno nicotinic acids |
US4072746A (en) * | 1975-10-14 | 1978-02-07 | Sterling Drug Inc. | 3-Amino-5-(pyridinyl)-2(1H)-pyridinones |
-
1981
- 1981-03-05 IL IL62306A patent/IL62306A0/en unknown
- 1981-03-06 AU AU68138/81A patent/AU6813881A/en not_active Abandoned
- 1981-03-09 NZ NZ196453A patent/NZ196453A/en unknown
- 1981-03-10 IT IT20272/81A patent/IT1141999B/en active
- 1981-03-10 PH PH25338A patent/PH15978A/en unknown
- 1981-03-11 NO NO810833A patent/NO810833L/en unknown
- 1981-03-11 GB GB8107632A patent/GB2073179A/en not_active Withdrawn
- 1981-03-12 SE SE8101592A patent/SE8101592L/en not_active Application Discontinuation
- 1981-03-13 FI FI810779A patent/FI810779L/en not_active Application Discontinuation
- 1981-03-16 ES ES500395A patent/ES500395A0/en active Granted
- 1981-03-16 NL NL8101269A patent/NL8101269A/en not_active Application Discontinuation
- 1981-03-16 DK DK117081A patent/DK117081A/en not_active Application Discontinuation
- 1981-03-16 LU LU83221A patent/LU83221A1/en unknown
- 1981-03-16 FR FR8105222A patent/FR2478098A1/en not_active Withdrawn
- 1981-03-17 DE DE19813110313 patent/DE3110313A1/en not_active Withdrawn
- 1981-03-17 PT PT72674A patent/PT72674B/en unknown
Also Published As
Publication number | Publication date |
---|---|
FI810779L (en) | 1981-09-18 |
SE8101592L (en) | 1981-09-18 |
PT72674A (en) | 1981-04-01 |
IT8120272A0 (en) | 1981-03-10 |
AU6813881A (en) | 1981-09-24 |
PT72674B (en) | 1982-03-22 |
GB2073179A (en) | 1981-10-14 |
DK117081A (en) | 1981-09-18 |
IL62306A0 (en) | 1981-05-20 |
NO810833L (en) | 1981-09-18 |
LU83221A1 (en) | 1981-10-30 |
FR2478098A1 (en) | 1981-09-18 |
NL8101269A (en) | 1981-10-16 |
DE3110313A1 (en) | 1981-12-24 |
PH15978A (en) | 1983-05-16 |
NZ196453A (en) | 1983-12-16 |
ES500395A0 (en) | 1982-06-01 |
IT1141999B (en) | 1986-10-08 |
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