ES8204726A1 - Procedimiento para la preparacion de acidos carboxilicos - Google Patents

Procedimiento para la preparacion de acidos carboxilicos

Info

Publication number
ES8204726A1
ES8204726A1 ES498766A ES498766A ES8204726A1 ES 8204726 A1 ES8204726 A1 ES 8204726A1 ES 498766 A ES498766 A ES 498766A ES 498766 A ES498766 A ES 498766A ES 8204726 A1 ES8204726 A1 ES 8204726A1
Authority
ES
Spain
Prior art keywords
thiazoline
thiazole
hydroxyphenyl
influencing
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES498766A
Other languages
English (en)
Other versions
ES498766A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES498766A0 publication Critical patent/ES498766A0/es
Publication of ES8204726A1 publication Critical patent/ES8204726A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/08—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D277/12—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Obesity (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS CARBOXILICOS Y DE SUS SALES CON BASES FISIOLOGICAMENTE COMPATIBLES DE FORMULA (I), EN LA QUE R2 ES HIDROGENO, HIDROXILO O METILO, R4 ES HIDROGENO O METILO Y R1 Y R3 PUEDEN SER VARIOS TIPOS DE RADICALES. CONSISTE EN LA REACCION DE CONDENSACION DE UN COMPUESTO DE FORMULA (II), EN LA QUE R1-R4 SONLOS MISMOS QUE EN LA FORMULA (I), CON CISTEINA O UNA DE SUS SALES. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO, A TEMPERATURA MODERADAMENTE ALTA. LA SEPARACION Y PURIFICACION DEL PRODUCTO SE EFECTUA SIGUIENDO METODOS CONVENCIONALES. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU EFECTO INHIBIDOR SOBRE LA BIOSINTESIS DEL COLAGENO.
ES498766A 1980-01-29 1981-01-23 Procedimiento para la preparacion de acidos carboxilicos Expired ES8204726A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19803002989 DE3002989A1 (de) 1980-01-29 1980-01-29 Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels

Publications (2)

Publication Number Publication Date
ES498766A0 ES498766A0 (es) 1982-05-01
ES8204726A1 true ES8204726A1 (es) 1982-05-01

Family

ID=6093111

Family Applications (2)

Application Number Title Priority Date Filing Date
ES498766A Expired ES8204726A1 (es) 1980-01-29 1981-01-23 Procedimiento para la preparacion de acidos carboxilicos
ES498750A Granted ES498750A0 (es) 1980-01-29 1981-01-23 Procedimiento para la preparacion de acidos carboxilicos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES498750A Granted ES498750A0 (es) 1980-01-29 1981-01-23 Procedimiento para la preparacion de acidos carboxilicos

Country Status (7)

Country Link
US (1) US4457936A (es)
EP (1) EP0033151B1 (es)
JP (1) JPS56120675A (es)
AT (1) ATE7297T1 (es)
CA (1) CA1171420A (es)
DE (2) DE3002989A1 (es)
ES (2) ES8204726A1 (es)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
USRE34656E (en) * 1983-12-29 1994-07-05 The Research Foundation Of State University Of New York Use of tetracycline to enhance bone protein synthesis and/or treatment of bone deficiency
US4666897A (en) * 1983-12-29 1987-05-19 Research Foundation Of State University Inhibition of mammalian collagenolytic enzymes by tetracyclines
US4935412A (en) * 1983-12-29 1990-06-19 The Research Foundation Of State University Of New York Non-antibacterial tetracycline compositions possessing anti-collagenolytic properties and methods of preparing and using same
DE3432094A1 (de) * 1984-08-31 1986-03-06 Hoechst Ag, 6230 Frankfurt Ester der pyridin-2,4- und -2,5- dicarbonsaeure als arzneimittel zur inhibierung der prolin- und lysinhydroxylase
DE3544338A1 (de) * 1985-12-14 1987-06-19 Hoechst Ag Peptid-derivate mit inhibitorischer wirkung auf hydroxylierende enzyme, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
IT1196485B (it) * 1986-07-14 1988-11-16 Zambon Spa Derivati dell'acido tiazolidin-4-carbossilico ad attivita' farmaceutica
JPS6339868A (ja) * 1986-08-04 1988-02-20 Otsuka Pharmaceut Factory Inc ジ低級アルキルフエノ−ル誘導体
DE3643012A1 (de) * 1986-12-17 1988-06-30 Hoechst Ag 2,3-disubstituierte isoxazolidine, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung
WO1992009279A1 (en) * 1990-11-30 1992-06-11 Teijin Limited 2-arylthiazole derivative and pharmaceutical composition containing the same
US5840739A (en) * 1992-11-16 1998-11-24 University Of Florida Research Foundation, Inc. Thiazoline acid derivatives
DK0842165T3 (da) * 1996-03-25 2001-08-06 Alcon Lab Inc Thiazolidin-4-carboxylsyrederivater som cytobeskyttende midler
EP0878480A1 (en) * 1997-05-14 1998-11-18 H.W. Prof. Dr. Müller A method for the improvement of neuronal regeneration
CA2355117A1 (en) 1998-02-19 1999-08-26 Gabe Soto .beta.-lactam-like chaperone inhibitors
US6083966A (en) 1998-08-31 2000-07-04 University Of Florida Thiazoline acid derivatives
WO2000016763A2 (en) 1998-09-21 2000-03-30 University Of Florida Research Foundation, Inc. Antimalarial agents
EP1488791A3 (en) * 1998-09-21 2005-04-06 University Of Florida Research Foundation, Inc. Antimalarial agents
WO2000033836A1 (en) * 1998-12-04 2000-06-15 Ontogen Corporation 5-membered heterocycles for the treatment of human diseases involving modulators of selectins
US6875883B2 (en) 2002-05-15 2005-04-05 Genzyme Corporation Synthesis of benzonitriles from substituted benzaldehyde
WO2005034949A1 (en) 2003-09-09 2005-04-21 University Of Florida Desferrithiocin derivatives and their use as iron chelators
US20120095058A1 (en) * 2003-12-03 2012-04-19 Hanauske-Abel H M Method of preventing survival of retrovirally cells and of inhibiting formation of infectious retroviruses
KR101519441B1 (ko) 2004-12-23 2015-05-12 아레나 파마슈티칼스, 인크. 5ｈｔ２ｃ 수용체 조정물질 조성물 및 그의 사용 방법
BRPI0610644B8 (pt) 2005-04-04 2021-05-25 Univ Florida composto e composição farmacêutica que compreende tal composto e um veículo ou diluente farmaceuticamente aceitável.
WO2008115433A1 (en) 2007-03-15 2008-09-25 University Of Florida Desferrithiocin polyether analogues
BR112012028321A2 (pt) 2010-05-04 2017-03-21 Shire Llc "compostos análogos de desazadesferrotiocina e desazadesferrotiocina poliéter como agentes de quelação de metal, composição farmacêutica e usos dos ditos compostos"
AU2012352025B2 (en) 2011-12-16 2018-01-18 University Of Florida Research Foundation, Inc. Uses of 4'-desferrithiocin analogs
WO2015077655A1 (en) 2013-11-22 2015-05-28 University Of Florida Research Foundation, Inc. Desferrithiocin analogs and uses thereof
JP2018515475A (ja) 2015-04-27 2018-06-14 ユニバーシティー オブ フロリダ リサーチ ファンデーション， インク． 代謝的にプログラムされた金属キレーターおよびその使用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB584981A (en) * 1945-03-12 1947-01-28 Herbert Clare Carrington Manufacture of thiazoline derivatives
US3809754A (en) * 1968-12-31 1974-05-07 Medial De Toledo & Cie Method of treating diseases of the mucous membrane using compounds of a thiazolidine carboxylic acid and pharmaceutical preparations thereof
US3882110A (en) * 1969-06-11 1975-05-06 Roussel Uclaf Novel 2-alkyl-5-thiazole-carboxylic acid derivatives
IT1050117B (it) * 1969-09-17 1981-03-10 Godo Shusei Kk Metodo per la sintesi dell acido aeruginoico
FR2062120A5 (es) * 1969-10-10 1971-06-25 Messier Fa
FR2141526B1 (es) * 1971-06-14 1975-05-30 Roussel Uclaf
DE2245560A1 (de) * 1972-09-16 1974-03-21 Basf Ag Verfahren zur herstellung von 4alkoxycarbonyl-2-thiazolinen
GB1584981A (en) * 1977-01-13 1981-02-18 Davy Instr Ltd Conveyor weigher
DE3002989A1 (de) * 1980-01-29 1981-07-30 Hoechst Ag, 6000 Frankfurt Hydroxyphenyl-thiazol, -thiazolin und -thiazolidin-carbonsaeuren, verfahren zu ihrer herstellung und ihre verwendung zur beeinflussung des kollagenstoffwechsels
US4367233A (en) * 1981-10-02 1983-01-04 American Home Products Corporation Inhibitors of mammalian collagenase

Also Published As

Publication number Publication date
JPS56120675A (en) 1981-09-22
EP0033151B1 (de) 1984-05-02
DE3002989A1 (de) 1981-07-30
ES8200670A1 (es) 1981-11-01
ES498766A0 (es) 1982-05-01
ATE7297T1 (de) 1984-05-15
DE3163339D1 (en) 1984-06-07
EP0033151A1 (de) 1981-08-05
ES498750A0 (es) 1981-11-01
US4457936A (en) 1984-07-03
CA1171420A (en) 1984-07-24

Similar Documents

Publication Publication Date Title
ES8200670A1 (es) Procedimiento para la preparacion de acidos carboxilicos
EP0482410A3 (en) Anti-microbial compounds, including substituted 2-cyclohexyl-amine derivatives and their preparation
IE820856L (en) Omega-cyano-1,omega-diphenyl-azaalkane derivatives.
ES476682A1 (es) Un procedimiento para la preparacion de nuevos dericados de 1-aza-biciclo (2,2,2)octano, utiles como psicotrupos.
ES8104264A1 (es) Procedimiento para la preparacion de n- (trimetoxibencil)- n'-fenilpiperazinas
ES8304977A1 (es) "procedimiento para la preparacion de derivados triptaminicos sustituidos de tieniloxipropanolaminas, racemicos y opticamente activos".
JPS5392729A (en) Adduct of dipeptide derivatives and amino acid derivatives and process for their preparation
DE3374005D1 (en) 1-methyl-5-nitro-imidazoline derivatives and therapeutic compositions which contain them as active principle
ZA83856B (en) Thiazaspirane derivatives,processes for their preparation,and medicaments
AU588414B2 (en) Methionine-substituted 1, 4-dihydropyridines, process for the preparation and their use
ES8703847A1 (es) Procedimiento para la obtencion de derivados de sulfonilgua-nidinopirimidina
AU553493B2 (en) 3,7alpha-diazacyclohepta(j,k)fluoriene derivatives
DE3470741D1 (en) Azolylmethylcycloacetals, process for their preparation and their use as medicaments
ES8305734A1 (es) "procedimiento para la preparacion de derivados de 5(6)-fenil-sulfoniloxi-bencimidazol".
ES8703855A1 (es) Procedimiento para la obtencion de derivados de sulfonilgua-nidinotriazina
AU573062B2 (en) Dihydrodithiazine derivatives
JPS52148036A (en) Lysinol derivatives
DK469381A (da) Piperidinderivater og fremgangsmaade til deres fremstilling
ES8707960A1 (es) Procedimiento para la obtencion de derivados de triazolo- (3,2-c)perhidroxazin-8-ona
IT1175916B (it) Nuovo procedimento per preparare composti farmacologicamente attivi contenenti un gruppo sulfossido
ES2153822T3 (es) Esteres del acido 2-amino-cinamico.
ES8504193A1 (es) Un procedimiento de preparacion de hexahidro-indolo-naftiridinas
ZA873224B (en) 3-amino-dihydropyridines,a process for their preparation,and their use in medicaments
JPS5283520A (en) Novel 2-arylthio-cyclopentanones
JPS53101373A (en) Imidazole-4(5)-carboxylic acid anilide derivatives