ES8204414A1 - Amides of p-isobutyl-phenyl-propionic acid - Google Patents

Amides of p-isobutyl-phenyl-propionic acid

Info

Publication number
ES8204414A1
ES8204414A1 ES504156A ES504156A ES8204414A1 ES 8204414 A1 ES8204414 A1 ES 8204414A1 ES 504156 A ES504156 A ES 504156A ES 504156 A ES504156 A ES 504156A ES 8204414 A1 ES8204414 A1 ES 8204414A1
Authority
ES
Spain
Prior art keywords
isobutyl
phenyl
propionic acid
amides
substituted amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES504156A
Other languages
Spanish (es)
Other versions
ES504156A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratori Prophin SpA
Original Assignee
Laboratori Prophin SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratori Prophin SpA filed Critical Laboratori Prophin SpA
Publication of ES504156A0 publication Critical patent/ES504156A0/en
Publication of ES8204414A1 publication Critical patent/ES8204414A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/12—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by halogen atoms or by nitro or nitroso groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Rheumatology (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)

Abstract

The amide derivatives of p-isobutyl-phenyl-propionic acid, having general formula < IMAGE > wherein X is the radical of a substituted amine, of the group comprising lysine, metatrifluorotoluidine, glutamic acid and aspartic acid, show a good anti- inflammatory activity, accompanied by favourable side properties. For the preparation of the compounds of the invention, the p-isobutyl-phenyl-propionic acid is chlorinated, and the chlorinated derivative is reacted with the proper substituted amine.
ES504156A 1980-07-22 1981-07-21 Amides of p-isobutyl-phenyl-propionic acid Expired ES8204414A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
IT23601/80A IT1193955B (en) 1980-07-22 1980-07-22 AMID DERIVATIVES OF P-ISOBUTYLPHENYLPROPIONIC ACID, PROCEDURE FOR THEIR PREPARATION AND RELATED PHARMACEUTICAL COMPOSITIONS

Publications (2)

Publication Number Publication Date
ES504156A0 ES504156A0 (en) 1982-05-16
ES8204414A1 true ES8204414A1 (en) 1982-05-16

Family

ID=11208465

Family Applications (1)

Application Number Title Priority Date Filing Date
ES504156A Expired ES8204414A1 (en) 1980-07-22 1981-07-21 Amides of p-isobutyl-phenyl-propionic acid

Country Status (16)

Country Link
JP (1) JPS5742663A (en)
KR (1) KR840001072B1 (en)
AR (1) AR226734A1 (en)
BE (1) BE889699A (en)
BR (1) BR8104728A (en)
CA (1) CA1181419A (en)
CH (1) CH648292A5 (en)
DE (1) DE3128676C2 (en)
ES (1) ES8204414A1 (en)
FR (1) FR2491456B1 (en)
GB (1) GB2080797B (en)
IN (1) IN153746B (en)
IT (1) IT1193955B (en)
LU (1) LU83497A1 (en)
MX (1) MX7038E (en)
PT (1) PT73400B (en)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4536346A (en) * 1983-05-06 1985-08-20 American Cyanamid Company Aralkanamidophenyl compounds
HU198446B (en) * 1987-09-25 1989-10-30 Richter Gedeon Vegyeszet Process for production of new amids of buten acid and medical compositions containing such active substances
IT1317826B1 (en) * 2000-02-11 2003-07-15 Dompe Spa AMIDES, USEFUL IN THE INHIBITION OF THE CHEMOTAXIS OF NEUTROPHILES INDUCED BY IL-8.
IT1318466B1 (en) * 2000-04-14 2003-08-25 Dompe Spa R-2- (AMINOARYL) -PROPIONIC ACIDS AMIDES, USEFUL IN THE PREVENTION OF LEUKOCYTIVE ACTIVATION.
ITMI20010395A1 (en) 2001-02-27 2002-08-27 Dompe Spa OMEGA-AMINO ALKYLAMIDS OF R-2-ARYL-PROPIONIC ACIDS AS INHIBITORS OF CHEMOTAXIS OF POLYMORPHONUCLEATED AND MONONUCLEATE CELLS
EP1457485A1 (en) 2003-03-14 2004-09-15 Dompé S.P.A. Sulfonic acids, their derivatives and pharmaceutical compositions containing them

Also Published As

Publication number Publication date
IN153746B (en) 1984-08-18
IT8023601A0 (en) 1980-07-22
MX7038E (en) 1987-03-18
BR8104728A (en) 1982-04-13
GB2080797A (en) 1982-02-10
FR2491456B1 (en) 1985-11-15
ES504156A0 (en) 1982-05-16
CA1181419A (en) 1985-01-22
KR840001072B1 (en) 1984-07-31
BE889699A (en) 1981-11-16
PT73400B (en) 1982-10-01
KR830006185A (en) 1983-09-20
FR2491456A1 (en) 1982-04-09
IT1193955B (en) 1988-08-31
LU83497A1 (en) 1981-10-29
JPS5742663A (en) 1982-03-10
CH648292A5 (en) 1985-03-15
DE3128676A1 (en) 1982-04-22
AR226734A1 (en) 1982-08-13
PT73400A (en) 1981-08-01
GB2080797B (en) 1984-01-18
DE3128676C2 (en) 1983-12-01

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991007