Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Symphar SA
Original Assignee
Symphar SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB7933157Aexternal-prioritypatent/GB2043072B/en
Application filed by Symphar SAfiledCriticalSymphar SA
Priority to ES498991ApriorityCriticalpatent/ES498991A0/es
Publication of ES8201592A1publicationCriticalpatent/ES8201592A1/es
Publication of ES498991A0publicationCriticalpatent/ES498991A0/es
Organic Low-Molecular-Weight Compounds And Preparation Thereof
(AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds
(AREA)
Abstract
PROCEDIMIENTO DE PREPARACION DE DERIVADOS DE GEM-DIFOSFONATO, DE FORMULA (I), EN QUE R Y R'' PUEDEN SER HIDROGENO, METILO, ETILO O BUTILO; Y A, UN GRUPO DE FORMULA (II), SIENDO Y HIDROGENO, METILO, HALOGENO U OTROS. SE HACE REACCIONAR UN METILENDIFOSFONATO DE TETRAETILO DE FORMULA (III) CON UN HALURO DE ARILALQUILO DE FORMULA (IV), SIENDO Z UN HALOGENO. LA REACCION SE EFECTUA A ELEVADA TEMPERATURA Y EN PRESENCIA DE UN AGENTE DE CONDENSACION ALCALINO. EL DIFOSFONATO DE TETRAETILO RESULTANTE SE HIDROLIZA CON UNA SOLUCION ACIDA, Y SE ESTERIFICA EL ACIDO. SE USAN COMO AGENTES ANTIATEROGENICOS EN EL TRATAMIENTO DE ENFERMEDADES CARDIOVASCULARES EN EL HOMBRE. *FORMULA*
ES498991A1979-09-251981-01-30Procedimiento para preparar derivados de gem-difosfonato
GrantedES498991A0
(es)