Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Laboratorios Rubio SA
Original Assignee
Laboratorios Rubio SA
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Filing date
Publication date
Application filed by Laboratorios Rubio SAfiledCriticalLaboratorios Rubio SA
Priority to ES493743ApriorityCriticalpatent/ES493743A0/en
Publication of ES8106493A1publicationCriticalpatent/ES8106493A1/en
Publication of ES493743A0publicationCriticalpatent/ES493743A0/en
Process for obtaining N[(2S)(-)-3-mercapto-2- methylpropanoyl]-L-proline. This comprises starting from L-proline amino acid, whose active hydrogens have been previously protected by reaction with trimethyl-monochloro-silane in order to form an anhydrous suspension of the protected derivative N-trimethyl silyl-L-prolinyl-trimethylsilyl-ester, and subsequently acylating the said protected L-proline derivative with an anhydrous solution of mixed anhydride formed in situ from (S)(-)-3-acetylthio-2-methyl- propionic ... of pivaloyl chloride. All in accordance with the following reaction:
ES493743A1980-07-261980-07-26
NEW PROCEDURE FOR OBTAINING N (25-3-MERCAPTO-2- METHYL-PROPANOIL) -L-PROLINE.
GrantedES493743A0
(en)
7-Amino-1-cyclopropyl-6,8-difluoro-1,4-dihydro-4-oxo-3-quinoline-carboxylic acid, processes for their preparation and antibacterial agents containing them.
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