ES8104296A1 - Intermediate compounds for preparation of morphine derivatives - Google Patents

Intermediate compounds for preparation of morphine derivatives

Info

Publication number
ES8104296A1
ES8104296A1 ES494122A ES494122A ES8104296A1 ES 8104296 A1 ES8104296 A1 ES 8104296A1 ES 494122 A ES494122 A ES 494122A ES 494122 A ES494122 A ES 494122A ES 8104296 A1 ES8104296 A1 ES 8104296A1
Authority
ES
Spain
Prior art keywords
preparation
intermediate compounds
morphine derivatives
hydroxynormorphones
dihydro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES494122A
Other languages
Spanish (es)
Other versions
ES494122A0 (en
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mallinckrodt Inc
Original Assignee
Mallinckrodt Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mallinckrodt Inc filed Critical Mallinckrodt Inc
Publication of ES494122A0 publication Critical patent/ES494122A0/en
Publication of ES8104296A1 publication Critical patent/ES8104296A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Saccharide Compounds (AREA)

Abstract

N-acyl-dihydro-14-hydroxynormorphones such as N-(cycloalkylcarbonyl)-dihydro-14-hydroxynormorphones which are intermediates useful in the preparation of morphine derivatives that are both narcotic antagonists as well as analagetics. A process for preparing these intermediates is also disclosed.
ES494122A 1979-08-09 1980-08-08 Intermediate compounds for preparation of morphine derivatives Expired ES8104296A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6527579A 1979-08-09 1979-08-09

Publications (2)

Publication Number Publication Date
ES494122A0 ES494122A0 (en) 1981-04-16
ES8104296A1 true ES8104296A1 (en) 1981-04-16

Family

ID=22061564

Family Applications (1)

Application Number Title Priority Date Filing Date
ES494122A Expired ES8104296A1 (en) 1979-08-09 1980-08-08 Intermediate compounds for preparation of morphine derivatives

Country Status (16)

Country Link
JP (1) JPS56501010A (en)
AU (1) AU6116580A (en)
BE (1) BE884671A (en)
DD (1) DD154541A5 (en)
DK (1) DK151781A (en)
ES (1) ES8104296A1 (en)
FI (1) FI802479A (en)
FR (1) FR2465735A1 (en)
GB (1) GB2066256A (en)
IL (1) IL60783A0 (en)
IT (1) IT8068267A0 (en)
NL (1) NL8020319A (en)
NO (1) NO802139L (en)
PL (1) PL226162A1 (en)
SE (1) SE8102214L (en)
WO (1) WO1981000409A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4795813A (en) * 1981-08-17 1989-01-03 The Florida Board Of Regents On Behalf Of The Florida State University Synthesis of derivatives of codeine and other 3-O-alkylmorphines
US5668285A (en) * 1986-10-31 1997-09-16 The United States Of America As Represented By The Department Of Health And Human Services Total synthesis of northebaine, normophine, noroxymorphone enantiomers and derivatives via N-Nor intermediates
DE69033035T2 (en) * 1989-10-16 1999-08-05 The United States of America, represented by the Secretary, U.S. Department of Commerce, Washington, D.C. TOTAL SYNTHESIS OF NORTHEBAIN, NORMORPHIN, NOROXYMORPHONE ENANTIOMERS AND DERIVATIVES VIA N-NOR INTERMEDIATE COMPOUNDS

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3249616A (en) * 1966-05-03 Ix-dfflydroxy-g-oxo-n-phenethylmor- phinan (cis) and production thereof
CA913077A (en) * 1972-10-24 J. Pachter Irwin Process of preparing n-substituted 14-hydroxydihydronormorphines
US2772270A (en) * 1954-10-21 1956-11-27 M J Lewenstein 14-hydroxymorphinone and 8, 14-dihydroxydihydromorphinone
US2806033A (en) * 1955-08-03 1957-09-10 Lewenstein Morphine derivative
BE638369A (en) * 1962-10-10
US3332950A (en) * 1963-03-23 1967-07-25 Endo Lab 14-hydroxydihydronormorphinone derivatives
NL7106612A (en) * 1971-05-13 1972-11-15 N-cycloalkylalkyl-14-hydroxy-dihydronormorphines - - by o-demethylation of 14-methoxy cpds
US3775414A (en) * 1972-05-10 1973-11-27 Bristol Myers Co Process for the preparation of 14-hydroxymorphinan derivatives
US4161597A (en) * 1976-12-20 1979-07-17 Research Corporation N-alkyl-14-hydroxymorphinans and derivatives

Also Published As

Publication number Publication date
DK151781A (en) 1981-04-03
SE8102214L (en) 1981-04-07
DD154541A5 (en) 1982-03-31
JPS56501010A (en) 1981-07-23
BE884671A (en) 1980-12-01
GB2066256A (en) 1981-07-08
ES494122A0 (en) 1981-04-16
NL8020319A (en) 1981-07-01
AU6116580A (en) 1981-02-12
FI802479A (en) 1981-02-10
NO802139L (en) 1981-02-10
FR2465735A1 (en) 1981-03-27
WO1981000409A1 (en) 1981-02-19
IT8068267A0 (en) 1980-08-07
PL226162A1 (en) 1981-04-24
IL60783A0 (en) 1980-10-26

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