ES485025A1 - A procedure for the preparation of 4-aza-5a-androstan-3-ona 17-replaced (Machine-translation by Google Translate, not legally binding)
- Google Patents
A procedure for the preparation of 4-aza-5a-androstan-3-ona 17-replaced (Machine-translation by Google Translate, not legally binding)
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Merck and Co Inc
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Merck and Co Inc
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Priority to ES485025ApriorityCriticalpatent/ES485025A1/en
Publication of ES485025A1publicationCriticalpatent/ES485025A1/en
A process for the preparation of 17-substituted 4-aza 5 -alpha-androstan-3-one of formula ** formula ** whose process comprises the following steps: (1) reacting 17beta-carboxy-4-androsten-3- ona with an oxidizing agent to form the corresponding 5-oxo-3,5-seco-androstam-3,17 beta-dioic acid, (2) react the product of step (1) with methylamine to form 17 beta-carboxy -4- methyl-4-aza-5-androstan-3-one, (3) react the product of step (2) with hydrogen under catalytic conditions, to form 17 beta-carboxy-4-methyl-4-aza -5 alpha-androstan-3-one, (4) form the sodium salt of the product of step (3) and react it with oxalyl chloride to form 17beta carbonylchloro-4-methyl-4-aza 5 alfa-androstan-3 -one and (5) react the product of step (4) with diethylamine to form the final product 17beta-N, N-diethylcarbamoyl-4-methyl-4-aza-5 alpha -androstan-3-one. (Machine-translation by Google Translate, not legally binding)
ES485025A1979-10-151979-10-15A procedure for the preparation of 4-aza-5a-androstan-3-ona 17-replaced (Machine-translation by Google Translate, not legally binding)
ExpiredES485025A1
(en)
Process for producing 3,5-di-bracket-terc-butyl-bracket closed-4-hydroxy-phenyl-bracket-alkyl-bracket closed-carbonyl-amino-alkyl-phenoxy-alkyl-carboxylic acid derivatives
Procedure for the preparation of the 1-arginine salt of the cis-5-fluoro-2-methyl-1- (p-metilsulfinil-benciliden) -3-indenil-acetic acid. (Machine-translation by Google Translate, not legally binding)