ES474282A1 - A procedure to produce a piridazinoma compound. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A method of producing a pharmaceutically acceptable pyridazinone compound of the formula (* see formula) and a corresponding acid addition salt, where A represents a methylene, ethylene or vinylene group, in the case that A is an ethylene group or vinylene, may be substituted by a lower alkyl group; R1 represents a hydrogen atom, a lower alkyl group, an alkanoyl group, an alkylsulfonyl group or a benzoyl group, which can be substituted by at least one substituent at any position or positions of the phenyl nucleus, each of these substituents can independently selected from the group consisting of a halogen atom, a lower alkyl group or a lower alkoxy group; R2 represents a hydrogen atom, an alkyl group, a lower hydroxyalkyl group, a carbamoylalkyl group, a naphthyloxyalkyl group, an oxoalkyl group or a group (R6) (R7) n- (CH2) n-, where R6 and R7 represent, each a hydrogen atom or a lower alkyl group, or R6 and R7, together with the adjacent nitrogen atom, form a heterocycle and is not 2 or 3; R3 represents a hydrogen atom; R4 represents a hydrogen atom, a lower alkyl group, a hydroxymethyl group or a lower alkanoyloxamethyl group; and R5 represents a hydrogen atom or a lower alkyl group; or R3 and one of R4 and R5, together form a single bond. (Machine-translation by Google Translate, not legally binding)