ES473544A1 - New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding) - Google Patents
New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES473544A1 ES473544A1 ES473544A ES473544A ES473544A1 ES 473544 A1 ES473544 A1 ES 473544A1 ES 473544 A ES473544 A ES 473544A ES 473544 A ES473544 A ES 473544A ES 473544 A1 ES473544 A1 ES 473544A1
- Authority
- ES
- Spain
- Prior art keywords
- alpha
- difluo
- beta
- methyl
- above compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
New procedure for the synthesis of diflucortolone valerate or 6 alpha, 9 alpha-difluo-11 beta-hydroxy, 16 alpha-methyl-21-valeryloxy, 1,4-pregnadiene-3, 20 dione which is obtained in a six-step process. From flumetasone, according to the following process: reaction of flumethasone with ethylene glycol in acid medium to obtain 6 alpha-9 alpha-difluo, 11 beta, 17 alpha, 21-dihydroxy, 16-alpha-methyl, 1-pregnen-3, 20-di (1,3-dioxolone); dehydration of the above compound with boric acid to obtain 6 alpha-9 alpha difluo, 11 beta, 21-dihydroxy, 16-alpha-methyl, 1,16-pregnadiene, 3,20-di (1,3-dioxolane); catalytic hydrogenation of the above compound with hydrogen gas in the presence of palladium or raney nickel with which 6 alpha, 9 alpha-difluo, 11 beta, 21-dihydroxy, 16-alpha-methyl, 1-pregnen, 3,20-di (1,3-dioxolane); acetic hydrolysis of the above compound to obtain 6 alpha, 9 alpha-difluo, 11 beta, hydroxy, 21-acetyloxy, 16-alpha-methyl, 1-pregnen, 3,20-dione; oxidation with selenium dioxide of the above compound to form a double bond in delta 1,2 with which we obtain 6 alpha, 9 alpha-difluo, 11 beta, 21-dihydroxy, 16-alpha-methyl, 1,4-prepnadien, 3,20-dione (dione (diflucortolone acetate); reaction of the above compound with potassium valerate to obtain diflucortolone valerate. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES473544A ES473544A1 (en) | 1978-09-21 | 1978-09-21 | New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES473544A ES473544A1 (en) | 1978-09-21 | 1978-09-21 | New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES473544A1 true ES473544A1 (en) | 1979-05-16 |
Family
ID=8476793
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES473544A Expired ES473544A1 (en) | 1978-09-21 | 1978-09-21 | New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES473544A1 (en) |
-
1978
- 1978-09-21 ES ES473544A patent/ES473544A1/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991209 |