ES473544A1 - New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding) - Google Patents

New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES473544A1
ES473544A1 ES473544A ES473544A ES473544A1 ES 473544 A1 ES473544 A1 ES 473544A1 ES 473544 A ES473544 A ES 473544A ES 473544 A ES473544 A ES 473544A ES 473544 A1 ES473544 A1 ES 473544A1
Authority
ES
Spain
Prior art keywords
alpha
difluo
beta
methyl
above compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES473544A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ct S A
Original Assignee
Ct S A
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct S A filed Critical Ct S A
Priority to ES473544A priority Critical patent/ES473544A1/en
Publication of ES473544A1 publication Critical patent/ES473544A1/en
Expired legal-status Critical Current

Links

Landscapes

  • Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

New procedure for the synthesis of diflucortolone valerate or 6 alpha, 9 alpha-difluo-11 beta-hydroxy, 16 alpha-methyl-21-valeryloxy, 1,4-pregnadiene-3, 20 dione which is obtained in a six-step process. From flumetasone, according to the following process: reaction of flumethasone with ethylene glycol in acid medium to obtain 6 alpha-9 alpha-difluo, 11 beta, 17 alpha, 21-dihydroxy, 16-alpha-methyl, 1-pregnen-3, 20-di (1,3-dioxolone); dehydration of the above compound with boric acid to obtain 6 alpha-9 alpha difluo, 11 beta, 21-dihydroxy, 16-alpha-methyl, 1,16-pregnadiene, 3,20-di (1,3-dioxolane); catalytic hydrogenation of the above compound with hydrogen gas in the presence of palladium or raney nickel with which 6 alpha, 9 alpha-difluo, 11 beta, 21-dihydroxy, 16-alpha-methyl, 1-pregnen, 3,20-di (1,3-dioxolane); acetic hydrolysis of the above compound to obtain 6 alpha, 9 alpha-difluo, 11 beta, hydroxy, 21-acetyloxy, 16-alpha-methyl, 1-pregnen, 3,20-dione; oxidation with selenium dioxide of the above compound to form a double bond in delta 1,2 with which we obtain 6 alpha, 9 alpha-difluo, 11 beta, 21-dihydroxy, 16-alpha-methyl, 1,4-prepnadien, 3,20-dione (dione (diflucortolone acetate); reaction of the above compound with potassium valerate to obtain diflucortolone valerate. (Machine-translation by Google Translate, not legally binding)
ES473544A 1978-09-21 1978-09-21 New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding) Expired ES473544A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES473544A ES473544A1 (en) 1978-09-21 1978-09-21 New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
ES473544A ES473544A1 (en) 1978-09-21 1978-09-21 New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding)

Publications (1)

Publication Number Publication Date
ES473544A1 true ES473544A1 (en) 1979-05-16

Family

ID=8476793

Family Applications (1)

Application Number Title Priority Date Filing Date
ES473544A Expired ES473544A1 (en) 1978-09-21 1978-09-21 New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES473544A1 (en)

Similar Documents

Publication Publication Date Title
Sowden et al. Optically active α, β-diglycerides
HK52097A (en) Process for the manufacture of budesonide
Breslow et al. Introduction of a 9 (11) double bond into steroids by selective free-radical halogenation
Hogg et al. The adrenal hormones and related compounds. I. A “direct” synthesis of hydrocortisone acetate and cortisone acetate from 11α-hydroxyprogesterone
Rowland et al. Macrocyclic Diterpenes Isolated from Tobacco. α-and β-3, 8, 13-Duvatriene-1, 5-diols
ES473544A1 (en) New procedure for synthesis of valerate of diflucortolone. (Machine-translation by Google Translate, not legally binding)
Herzog et al. 11-Oxygenated Steroids. I. Partial Syntheses of 11-Ketotestosterone and of Adrenosterone
JPS52215A (en) Process for preparation of formaldehyde
Bernstein et al. Steroidal Cyclic Ketals. VIII. 1▵ 4, 9 (11)-Pregnadi ene-17α, 21-diol-3, 20-dione
Boeckman Jr et al. Synthesis and reactivity of endocyclic α, β-epoxy-γ-butyrolactones
US3069421A (en) Process for the preparation of delta5(10)-estrene-17beta-ol-3-one and intermediates
ES370889A1 (en) Improvements in or relating to therapeutic methods using prostaglandins
US2740797A (en) Steroids
Burstein 2α-HYDROXYLATION OF CORTISOL IN THE GUINEA PIG1
Corey et al. Conversion of 6-demethyl-2, 3-oxidosqualene to 19-norlanosterol by 3, 3-oxidosqualene--sterol cyclase
Agnello et al. Corticosteroid Intermediates. V. Rearrangements of C-Ring Oxygenated Steroids1
Hart et al. Cyclopropane Chemistry. IX. Nitrous Acid Deamination of 1-Amino-and 1-Aminomethylnortricyclene1, 2
Naya et al. The structure of petasitolone, a new constituent of Petasites japonicus Maxim
Gut et al. Synthesis of Radioactive Dehydroepiandrosterone1, 2
US2894002A (en) 2, 4b-dimethyl-1-acetaldehydo-2-methallyl-1, 2, 3, 4, 4a, 4b, 5, 6, 7, 9, 10, 10a-dodecahydrophenanthrene-4, 7-dione and methods of preparing the same
IT1161942B (en) PROCESS FOR THE PRODUCTION OF ETHYL ACETATE BY APPROVAL OF METHYL ACETATE
US3192237A (en) Hydrogenation of 5-unsaturated steroidal 16-ylidenalkylcarboxylic acids
GB889309A (en) 17-carboxyalkylated 3-oxygenated 6-methyl-androsten-17-ol lactones and intermediates therefor
ES414653A1 (en) Procedure for the preparation of 6 alpha-methyl-9 alpha-fluor - 11 beta, 17 alfadihidroxi-pregna-1,4-dien-3,20-diona. (Machine-translation by Google Translate, not legally binding)
GB788302A (en) The manufacture of geranyl-acetone and dihydrogeranyl-acetone and of hexahydro-pseudoionone therefrom

Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19991209