ES470430A1 - Un metodo para preparar pseudotrisacaridos - Google Patents

Un metodo para preparar pseudotrisacaridos

Info

Publication number
ES470430A1
ES470430A1 ES470430A ES470430A ES470430A1 ES 470430 A1 ES470430 A1 ES 470430A1 ES 470430 A ES470430 A ES 470430A ES 470430 A ES470430 A ES 470430A ES 470430 A1 ES470430 A1 ES 470430A1
Authority
ES
Spain
Prior art keywords
compounds
kanamycin
active
deoxy
synthetic aminoglycosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES470430A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB2400276A external-priority patent/GB1579029A/en
Application filed by Individual filed Critical Individual
Publication of ES470430A1 publication Critical patent/ES470430A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/224—Cyclohexane rings substituted by at least two nitrogen atoms with only one saccharide radical directly attached to the cyclohexyl radical, e.g. destomycin, fortimicin, neamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/20—Carbocyclic rings
    • C07H15/22—Cyclohexane rings, substituted by nitrogen atoms
    • C07H15/222—Cyclohexane rings substituted by at least two nitrogen atoms
    • C07H15/226—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings
    • C07H15/234—Cyclohexane rings substituted by at least two nitrogen atoms with at least two saccharide radicals directly attached to the cyclohexane rings attached to non-adjacent ring carbon atoms of the cyclohexane rings, e.g. kanamycins, tobramycin, nebramycin, gentamicin A2

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Oncology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Preparación de aminoglicósidos. En particular, la invención se refiere a un método de preparar pseudotrisacáridos que tienen actividad antibiótica. Los antibióticos bien conocidos de los tipo de la Kanamicina, Gentamicina y Apramicina son amino-pseudotrisacáridos. Los antibióticos conocidos exhiben actividad contra una amplia gama de bacterias. Sin embargo, están llegando a ser muy generalizadas cepas de bacterias que presentan resistencia a estos tipos de antibióticos. Esto constituye un problema importante debido a que las cepas resistentes de bacterias tienden a producir toxinas más peligrosas que las cepas no resistentes. La presente invención se basa en el descubrimiento de que por sustitución al menos parcial de los anillos normales de estos antibióticos por anillos desoxi pueden obtenerse compuestos que tienen una actividad notablemente mejorada cuando se comparan con los correspondientes antibióticos conocidos contra tales microorganismos resistentes.
ES470430A 1976-06-10 1978-06-01 Un metodo para preparar pseudotrisacaridos Expired ES470430A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB2400276A GB1579029A (en) 1976-06-10 1976-06-10 Synthetic aminoglycosides
GB4549276 1976-11-02

Publications (1)

Publication Number Publication Date
ES470430A1 true ES470430A1 (es) 1979-10-16

Family

ID=26256831

Family Applications (3)

Application Number Title Priority Date Filing Date
ES459606A Expired ES459606A1 (es) 1976-06-10 1977-06-08 Un metodo para preparar pseudotrisacaridos.
ES470429A Expired ES470429A1 (es) 1976-06-10 1978-06-01 Un metodo para preparar pseudotriscaridos
ES470430A Expired ES470430A1 (es) 1976-06-10 1978-06-01 Un metodo para preparar pseudotrisacaridos

Family Applications Before (2)

Application Number Title Priority Date Filing Date
ES459606A Expired ES459606A1 (es) 1976-06-10 1977-06-08 Un metodo para preparar pseudotrisacaridos.
ES470429A Expired ES470429A1 (es) 1976-06-10 1978-06-01 Un metodo para preparar pseudotriscaridos

Country Status (7)

Country Link
US (1) US4208531A (es)
JP (1) JPS52156834A (es)
DE (1) DE2726113A1 (es)
ES (3) ES459606A1 (es)
FR (1) FR2354341A1 (es)
NL (1) NL7706395A (es)
PT (1) PT66654B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171356A (en) * 1976-10-28 1979-10-16 Schering Corporation 2-Unsubstituted derivatives of 4,6-di-o-(aminoglycosyl)-1,3-diaminocyclitois, methods for their use as antibacterial agents and compositions useful therefor
US7794713B2 (en) 2004-04-07 2010-09-14 Lpath, Inc. Compositions and methods for the treatment and prevention of hyperproliferative diseases
US7862812B2 (en) 2006-05-31 2011-01-04 Lpath, Inc. Methods for decreasing immune response and treating immune conditions
KR101272351B1 (ko) * 2010-04-23 2013-06-07 이화여자대학교 산학협력단 새로운 카나마이신 화합물, 카나마이신 생산 스트렙토마이세스 속 미생물 및 카나마이신의 생산 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE402777C (sv) * 1972-12-29 1979-02-05 Takeda Chemical Industries Ltd Sett att framstella aminoglykosidantibiotika av 3'- och/eller 5''-dioxineomycintyp, 3'- och/eller 2''-dioxikanamycintyp eller 3''-dioxistryptomycintyp
US4063015A (en) * 1973-08-27 1977-12-13 Schering Corporation Garamine and derivatives thereof
US4051315A (en) * 1974-11-13 1977-09-27 Bristol-Myers Company 6"-Deoxykanamycin B and 6"-deoxytobramycin
FR2290908A1 (fr) * 1974-11-13 1976-06-11 Roussel Uclaf Nouveau derive aminoglycosidique et ses sels, leur procede de preparation et leur application comme medicaments

Also Published As

Publication number Publication date
PT66654B (en) 1978-11-10
FR2354341A1 (fr) 1978-01-06
JPS52156834A (en) 1977-12-27
NL7706395A (nl) 1977-12-13
PT66654A (en) 1977-07-01
ES470429A1 (es) 1979-01-01
US4208531A (en) 1980-06-17
ES459606A1 (es) 1978-12-16
FR2354341B1 (es) 1980-03-07
DE2726113A1 (de) 1977-12-22

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