ES465073A1 - Procedure for obtaining naloxone from tebaina (Machine-translation by Google Translate, not legally binding) - Google Patents
Procedure for obtaining naloxone from tebaina (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES465073A1 ES465073A1 ES465073A ES465073A ES465073A1 ES 465073 A1 ES465073 A1 ES 465073A1 ES 465073 A ES465073 A ES 465073A ES 465073 A ES465073 A ES 465073A ES 465073 A1 ES465073 A1 ES 465073A1
- Authority
- ES
- Spain
- Prior art keywords
- obtaining
- naloxone
- translation
- legally binding
- google translate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Abstract
Process for obtaining naloxone from thebaine.- essentially characterized in that it consists of separately obtaining dihydroxydeinone starting from thebaine, subsequently breaking the phenolic ether of the dihydroxydeinone by means of pyridine salts of a strong acid and in a solvent such as dimethylsulfoxide, demethylating the oxycodone, obtaining as an intermediate element oxymorphone, subsequently treating said oxymorphone with alkyl chloroformates, protecting the phenolic group and eliminating the methyl linked to the nitrogen by transformation to an intermediate derivative of the urethane type, obtaining the nordihydroxymorphinone by hydrolysis of the derivative. Intermediate, subsequently producing the alkylation of the nitrogen by unsaturated alkyl halides, obtaining naloxone in basic and solid state, said naoloxone being subjected to a washing and subsequent crystallization, which gives rise to a pure product which is the starting base for the tion of denaloxone salts. (Machine-translation by Google Translate, not legally binding)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES465073A ES465073A1 (en) | 1977-12-14 | 1977-12-14 | Procedure for obtaining naloxone from tebaina (Machine-translation by Google Translate, not legally binding) |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES465073A ES465073A1 (en) | 1977-12-14 | 1977-12-14 | Procedure for obtaining naloxone from tebaina (Machine-translation by Google Translate, not legally binding) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES465073A1 true ES465073A1 (en) | 1979-01-01 |
Family
ID=8475086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES465073A Expired ES465073A1 (en) | 1977-12-14 | 1977-12-14 | Procedure for obtaining naloxone from tebaina (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
| Country | Link |
|---|---|
| ES (1) | ES465073A1 (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3252055A1 (en) | 2016-05-31 | 2017-12-06 | Alcaliber Investigacion Desarrollo e Innovacion, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
-
1977
- 1977-12-14 ES ES465073A patent/ES465073A1/en not_active Expired
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3252055A1 (en) | 2016-05-31 | 2017-12-06 | Alcaliber Investigacion Desarrollo e Innovacion, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
| WO2017207519A1 (en) | 2016-05-31 | 2017-12-07 | Alcaliber Investigación Desarrollo E Innovación, S.L. | Process for obtaining 3,14-diacetyloxymorphone from oripavine |
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