ES461388A1 - 1,5-disubstituted - 2 - pyrrolidones - Google Patents
1,5-disubstituted - 2 - pyrrolidonesInfo
- Publication number
- ES461388A1 ES461388A1 ES461388A ES461388A ES461388A1 ES 461388 A1 ES461388 A1 ES 461388A1 ES 461388 A ES461388 A ES 461388A ES 461388 A ES461388 A ES 461388A ES 461388 A1 ES461388 A1 ES 461388A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- alkyl
- carbon atoms
- tetrazol
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
- C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/24—Oxygen or sulfur atoms
- C07D207/26—2-Pyrrolidones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A process for the preparation of a pyrrolidone compound of the formula: ** (Formula) ** and the C5 epimer thereof, where: Q is -COOR'', tetrazol-5-yl or -CONHR "; W is a single bond or a double bond with a cis configuration; Z is a single bond or a double bond with a trans configuration; M is H/"'' OH or HO /"'' H; R is alpha-thienyl, phenyl, monosubstituted phenoxy or monosubstituted phenoxy, in which the substituent is chlorine, fluorine, phenyl, methoxy trifluomethyl or alkyl having one to three carbon atoms; R'' is hydrogen, alkyl having one to five carbon atoms, phenyl or p- biphenyl; R "is -COR''" or -SO2R'' ", where R"'' is phenyl or alkyl having one to five carbon atoms; and the alkali metal, alkaline earth metal, and ammonium salts of those compounds in which Q is a carboxylate or tetrazol-5-yl group. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US71236276A | 1976-08-06 | 1976-08-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES461388A1 true ES461388A1 (en) | 1978-12-01 |
Family
ID=24861795
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES461388A Expired ES461388A1 (en) | 1976-08-06 | 1977-08-05 | 1,5-disubstituted - 2 - pyrrolidones |
| ES471349A Expired ES471349A1 (en) | 1976-08-06 | 1978-07-01 | 1,5-disubstituted - 2 - pyrrolidones |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES471349A Expired ES471349A1 (en) | 1976-08-06 | 1978-07-01 | 1,5-disubstituted - 2 - pyrrolidones |
Country Status (31)
| Country | Link |
|---|---|
| JP (2) | JPS5321159A (en) |
| AR (1) | AR217080A1 (en) |
| AT (1) | AT362887B (en) |
| AU (1) | AU508007B2 (en) |
| BE (1) | BE857506A (en) |
| BG (1) | BG31073A3 (en) |
| CA (1) | CA1077948A (en) |
| CH (1) | CH624934A5 (en) |
| CS (1) | CS221269B2 (en) |
| DD (2) | DD143768A5 (en) |
| DE (1) | DE2735904A1 (en) |
| DK (1) | DK352077A (en) |
| ES (2) | ES461388A1 (en) |
| FI (1) | FI70009C (en) |
| FR (1) | FR2369260A1 (en) |
| GB (2) | GB1556569A (en) |
| GR (1) | GR68688B (en) |
| HU (1) | HU180273B (en) |
| IE (1) | IE45505B1 (en) |
| IL (1) | IL52615A (en) |
| LU (1) | LU77936A1 (en) |
| NL (1) | NL7708637A (en) |
| NO (1) | NO772752L (en) |
| NZ (1) | NZ184806A (en) |
| PH (1) | PH17398A (en) |
| PL (2) | PL112931B1 (en) |
| PT (1) | PT66891B (en) |
| SE (1) | SE423813B (en) |
| SU (3) | SU703016A3 (en) |
| YU (1) | YU192577A (en) |
| ZA (1) | ZA774704B (en) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5695569A (en) * | 1979-12-27 | 1981-08-03 | Canon Inc | Forming method for bar lens sphere face |
| US4321201A (en) * | 1980-09-22 | 1982-03-23 | E. I. Du Pont De Nemours And Company | Optically active tert-alkyl 7-(2-oxo-5-carbonyloxypyrrolidinyl) heptanoates |
| JPS59137224A (en) * | 1983-01-25 | 1984-08-07 | Mitsubishi Electric Corp | Feed voltage compensator for electric railroad |
| ATE327751T1 (en) | 2000-01-31 | 2006-06-15 | Pfizer Prod Inc | USE OF PROSTAGLAND RECEPTOR 4 ACTIVATORS FOR THE TREATMENT OF ACUTE OR CHRONIC RENAL INSUFFICIENCY |
| WO2002024647A1 (en) * | 2000-09-21 | 2002-03-28 | Ono Pharmaceutical Co., Ltd. | Ep4 receptor agonists containing 8-azaprostaglandin derivatives as the active ingredient |
| PT1339678E (en) * | 2000-11-27 | 2007-11-30 | Pfizer Prod Inc | Ep4 receptor selective agonists in the treatment of osteoporosis |
| TWI313608B (en) * | 2001-07-23 | 2009-08-21 | Ono Pharmaceutical Co | Lower bone mass treating agent containing er4 agonist as active ingredient |
| MXPA04005555A (en) * | 2002-03-18 | 2005-05-16 | Pfizer Prod Inc | Methods of treatment with selective ep4 receptor agonists. |
| US6573294B1 (en) * | 2002-05-14 | 2003-06-03 | Allergan, Inc. | 8-azaprostaglandin analogs as agents for lowering intraocular pressure |
| US7256211B1 (en) * | 2003-01-21 | 2007-08-14 | Ono Pharmaceutical Co., Ltd. | 8-azaprostaglandin derivatives and medical use thereof |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1386146A (en) * | 1972-05-03 | 1975-03-05 | Ici Ltd | Cyclopentane derivatives |
| JPS511460A (en) * | 1974-06-24 | 1976-01-08 | Tanabe Seiyaku Co | 22 piroridonjudotaino seiho |
| JPS514166A (en) * | 1974-06-28 | 1976-01-14 | Tanabe Seiyaku Co | 22PIRORIDONJUDOTAINO SEIHO |
| US3975399A (en) * | 1974-08-06 | 1976-08-17 | E. I. Du Pont De Nemours And Company | 1,5-Disubstituted-2-pyrrolidinones, -3-pyrrolin-2-ones, and -4-pyrrolin-2-ones |
| DE2528664A1 (en) * | 1975-06-27 | 1977-01-13 | Hoechst Ag | PYRROLIDONE AND THE METHOD FOR MANUFACTURING THEIR |
-
1977
- 1977-07-27 CA CA283,598A patent/CA1077948A/en not_active Expired
- 1977-07-27 SE SE7708642A patent/SE423813B/en unknown
- 1977-07-28 IL IL52615A patent/IL52615A/en unknown
- 1977-07-28 GR GR54058A patent/GR68688B/el unknown
- 1977-08-01 AU AU27515/77A patent/AU508007B2/en not_active Expired
- 1977-08-02 NZ NZ184806A patent/NZ184806A/en unknown
- 1977-08-02 PH PH20060A patent/PH17398A/en unknown
- 1977-08-04 NL NL7708637A patent/NL7708637A/en not_active Application Discontinuation
- 1977-08-04 PT PT66891A patent/PT66891B/en unknown
- 1977-08-04 ZA ZA00774704A patent/ZA774704B/en unknown
- 1977-08-05 CH CH964677A patent/CH624934A5/fr not_active IP Right Cessation
- 1977-08-05 ES ES461388A patent/ES461388A1/en not_active Expired
- 1977-08-05 BG BG037109A patent/BG31073A3/en unknown
- 1977-08-05 YU YU01925/77A patent/YU192577A/en unknown
- 1977-08-05 SU SU772511155A patent/SU703016A3/en active
- 1977-08-05 GB GB33002/77A patent/GB1556569A/en not_active Expired
- 1977-08-05 FI FI772376A patent/FI70009C/en not_active IP Right Cessation
- 1977-08-05 HU HU77PI587A patent/HU180273B/en unknown
- 1977-08-05 IE IE1641/77A patent/IE45505B1/en unknown
- 1977-08-05 FR FR7724290A patent/FR2369260A1/en active Granted
- 1977-08-05 DK DK352077A patent/DK352077A/en not_active Application Discontinuation
- 1977-08-05 AR AR268699A patent/AR217080A1/en active
- 1977-08-05 DD DD77213369A patent/DD143768A5/en unknown
- 1977-08-05 NO NO772752A patent/NO772752L/en unknown
- 1977-08-05 LU LU77936A patent/LU77936A1/xx unknown
- 1977-08-05 DE DE19772735904 patent/DE2735904A1/en not_active Ceased
- 1977-08-05 DD DD77200468A patent/DD136135A5/en unknown
- 1977-08-05 BE BE1008318A patent/BE857506A/en not_active IP Right Cessation
- 1977-08-05 GB GB43588/78A patent/GB1556570A/en not_active Expired
- 1977-08-05 CS CS775202A patent/CS221269B2/en unknown
- 1977-08-06 JP JP9458977A patent/JPS5321159A/en active Granted
- 1977-08-08 PL PL1977215666A patent/PL112931B1/en unknown
- 1977-08-08 AT AT0579477A patent/AT362887B/en not_active IP Right Cessation
- 1977-08-08 PL PL77200124A patent/PL200124A1/en unknown
-
1978
- 1978-07-01 ES ES471349A patent/ES471349A1/en not_active Expired
- 1978-10-11 SU SU782672200A patent/SU818480A3/en active
- 1978-10-17 SU SU782674602A patent/SU850000A3/en active
-
1979
- 1979-09-03 JP JP54112743A patent/JPS585196B2/en not_active Expired
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19981103 |