ES460993A1 - Pyrrolidine and pyrroline derivatives - Google Patents
Pyrrolidine and pyrroline derivativesInfo
- Publication number
- ES460993A1 ES460993A1 ES460993A ES460993A ES460993A1 ES 460993 A1 ES460993 A1 ES 460993A1 ES 460993 A ES460993 A ES 460993A ES 460993 A ES460993 A ES 460993A ES 460993 A1 ES460993 A1 ES 460993A1
- Authority
- ES
- Spain
- Prior art keywords
- phenyl
- substituted
- formula
- tertiary amino
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Heterocyclic compounds of the formula < IMAGE > in which R<1> is 2-thienyl or is phenyl which is substituted by a lower tertiary amino group, R<2> and R<3> are, independently of one another, hydrogen or lower alkyl and R<4> is phenyl which can be substituted by halogen, lower alkyl, lower alkoxy or primary, lower secondary or lower tertiary amino, where R<1> is phenyl substituted by a lower tertiary amino group if R<4> is phenyl or halogen-substituted phenyl, are prepared by reducing a compound of the formula < IMAGE > or an N-oxide of a compound of the formula II. It is furthermore possible for a phenyl group R<4> to be converted by nitration into a nitrophenyl group resulting bases can be converted into acid addition salts resulting mixtures of cis and trans isomers can be fractionated, and resulting racemates can be resolved into the optical antipodes. The products have an analgesic activity and can be used to control pain.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AT549076A AT355012B (en) | 1976-07-26 | 1976-07-26 | METHOD FOR PRODUCING NEW PYRROLIDINE DERIVATIVES, THEIR RACEMATS, OPTICAL ANTI-PODES, THE CIS AND TRANS-ISOMERS AND THEIR MIXTURES AND ACID ADDITIONAL SALTS OF THEM |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES460993A1 true ES460993A1 (en) | 1978-05-01 |
Family
ID=3576384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES460993A Expired ES460993A1 (en) | 1976-07-26 | 1977-07-23 | Pyrrolidine and pyrroline derivatives |
Country Status (26)
| Country | Link |
|---|---|
| JP (1) | JPS5315365A (en) |
| AR (1) | AR220682A1 (en) |
| AT (1) | AT355012B (en) |
| AU (1) | AU512688B2 (en) |
| BE (1) | BE857098A (en) |
| CH (1) | CH629188A5 (en) |
| DE (1) | DE2733232A1 (en) |
| DK (1) | DK333877A (en) |
| ES (1) | ES460993A1 (en) |
| FI (1) | FI772269A (en) |
| FR (1) | FR2359824A1 (en) |
| GB (1) | GB1564656A (en) |
| GR (1) | GR72106B (en) |
| HU (1) | HU174926B (en) |
| IE (1) | IE45171B1 (en) |
| IL (1) | IL52557A (en) |
| IT (1) | IT1143737B (en) |
| LU (1) | LU77826A1 (en) |
| MC (1) | MC1158A1 (en) |
| NL (1) | NL7708280A (en) |
| NO (1) | NO146467C (en) |
| NZ (1) | NZ184691A (en) |
| PH (1) | PH12499A (en) |
| PT (1) | PT66845B (en) |
| SE (1) | SE424988B (en) |
| ZA (1) | ZA774345B (en) |
-
1976
- 1976-07-26 AT AT549076A patent/AT355012B/en not_active IP Right Cessation
-
1977
- 1977-06-17 CH CH746077A patent/CH629188A5/en not_active IP Right Cessation
- 1977-06-30 IT IT25264/77A patent/IT1143737B/en active
- 1977-07-01 GR GR54020A patent/GR72106B/el unknown
- 1977-07-19 IL IL52557A patent/IL52557A/en unknown
- 1977-07-19 ZA ZA00774345A patent/ZA774345B/en unknown
- 1977-07-20 IE IE1518/77A patent/IE45171B1/en unknown
- 1977-07-20 AU AU27158/77A patent/AU512688B2/en not_active Expired
- 1977-07-20 NZ NZ184691A patent/NZ184691A/en unknown
- 1977-07-21 MC MC771253A patent/MC1158A1/en unknown
- 1977-07-22 LU LU77826A patent/LU77826A1/xx unknown
- 1977-07-22 NO NO772626A patent/NO146467C/en unknown
- 1977-07-22 DE DE19772733232 patent/DE2733232A1/en not_active Withdrawn
- 1977-07-22 AR AR268536A patent/AR220682A1/en active
- 1977-07-22 JP JP8750577A patent/JPS5315365A/en active Pending
- 1977-07-22 FR FR7722582A patent/FR2359824A1/en active Granted
- 1977-07-22 HU HU77HO2005A patent/HU174926B/en unknown
- 1977-07-22 DK DK333877A patent/DK333877A/en not_active Application Discontinuation
- 1977-07-23 ES ES460993A patent/ES460993A1/en not_active Expired
- 1977-07-25 BE BE179585A patent/BE857098A/en unknown
- 1977-07-25 SE SE7708536A patent/SE424988B/en unknown
- 1977-07-25 PT PT66845A patent/PT66845B/en unknown
- 1977-07-25 FI FI772269A patent/FI772269A/fi not_active Application Discontinuation
- 1977-07-25 GB GB31113/77A patent/GB1564656A/en not_active Expired
- 1977-07-26 NL NL7708280A patent/NL7708280A/en not_active Application Discontinuation
- 1977-07-26 PH PH20033A patent/PH12499A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AT355012B (en) | 1980-02-11 |
| IE45171B1 (en) | 1982-06-30 |
| NO146467C (en) | 1982-10-06 |
| FI772269A (en) | 1978-01-27 |
| AU2715877A (en) | 1979-01-25 |
| IE45171L (en) | 1978-01-26 |
| IL52557A (en) | 1980-02-29 |
| NL7708280A (en) | 1978-01-30 |
| DK333877A (en) | 1978-01-27 |
| HU174926B (en) | 1980-04-28 |
| IL52557A0 (en) | 1977-10-31 |
| PH12499A (en) | 1979-04-05 |
| JPS5315365A (en) | 1978-02-13 |
| MC1158A1 (en) | 1978-04-17 |
| NZ184691A (en) | 1980-05-08 |
| FR2359824B1 (en) | 1981-01-09 |
| BE857098A (en) | 1978-01-25 |
| AR220682A1 (en) | 1980-11-28 |
| ZA774345B (en) | 1978-06-28 |
| FR2359824A1 (en) | 1978-02-24 |
| ATA549076A (en) | 1979-07-15 |
| SE7708536L (en) | 1978-01-27 |
| AU512688B2 (en) | 1980-10-23 |
| DE2733232A1 (en) | 1978-02-09 |
| NO772626L (en) | 1978-01-27 |
| GB1564656A (en) | 1980-04-10 |
| PT66845A (en) | 1977-08-01 |
| PT66845B (en) | 1979-06-07 |
| IT1143737B (en) | 1986-10-22 |
| GR72106B (en) | 1983-09-14 |
| NO146467B (en) | 1982-06-28 |
| SE424988B (en) | 1982-08-23 |
| LU77826A1 (en) | 1978-09-14 |
| CH629188A5 (en) | 1982-04-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FD1A | Patent lapsed |
Effective date: 19991102 |