ES460371A1 - Procedimiento para la obtencion de derivados de la isoquino-leina. - Google Patents

Procedimiento para la obtencion de derivados de la isoquino-leina.

Info

Publication number
ES460371A1
ES460371A1 ES460371A ES460371A ES460371A1 ES 460371 A1 ES460371 A1 ES 460371A1 ES 460371 A ES460371 A ES 460371A ES 460371 A ES460371 A ES 460371A ES 460371 A1 ES460371 A1 ES 460371A1
Authority
ES
Spain
Prior art keywords
alkyl
alkoxy
halogen
hydrogen
phenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES460371A
Other languages
English (en)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz AG
Original Assignee
Sandoz AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from CH863276A external-priority patent/CH622783A5/de
Priority claimed from CH863176A external-priority patent/CH622782A5/de
Application filed by Sandoz AG filed Critical Sandoz AG
Publication of ES460371A1 publication Critical patent/ES460371A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/04—Ortho- or peri-condensed ring systems
    • C07D221/06—Ring systems of three rings
    • C07D221/08—Aza-anthracenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/60—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D211/62—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4
    • C07D211/66—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals attached in position 4 having a hetero atom as the second substituent in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Psychiatry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedimiento para la obtención de derivados de la isoquinoleina de fórmula I, **Fórmula** en la que R1 significa un átomo de hidrógeno, de flúor, de cloro o de bromo, o un grupo alquilo o alcoxi que contienen, cada uno, de 1 a 4 átomos de carbono, R2 significa un átomo de hidrógeno, un grupo alquilo que contiene de 1 a 6 átomos de carbono, un grupo alquenilo o alquinilo que contienen, cada uno, de 3 a 6 átomos de carbono y cuyo enlace múltiple no se halla en posición alfa con relación al átomo de nitrógeno al cual este grupo está unido; y R3 significa un átomo de hidrógeno, un grupo alquilo que contiene de 1 a 4 átomos de carbono, el grupo tienilo o un grupo fenilo que lleva eventualmente uno o dos substituyentes seleccionados entre los átomos de flúor, de cloro y de bromo y los grupos alquilo, alcoxi y alquiltio que contienen de 1 a 4 átomos de carbono, y sus sales de adición de ácidos.
ES460371A 1976-07-06 1977-07-04 Procedimiento para la obtencion de derivados de la isoquino-leina. Expired ES460371A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH863276A CH622783A5 (en) 1976-07-06 1976-07-06 Process for the preparation of novel hexahydrobenz[g]isoquinoline derivatives
CH863176A CH622782A5 (en) 1976-07-06 1976-07-06 Process for the preparation of novel hexahydrobenz[g]isoquinoline derivatives

Publications (1)

Publication Number Publication Date
ES460371A1 true ES460371A1 (es) 1979-05-01

Family

ID=25703556

Family Applications (2)

Application Number Title Priority Date Filing Date
ES460371A Expired ES460371A1 (es) 1976-07-06 1977-07-04 Procedimiento para la obtencion de derivados de la isoquino-leina.
ES476889A Expired ES476889A1 (es) 1976-07-06 1979-01-16 Procedimiento para la obtencion de derivados de la isoquino-leina.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES476889A Expired ES476889A1 (es) 1976-07-06 1979-01-16 Procedimiento para la obtencion de derivados de la isoquino-leina.

Country Status (19)

Country Link
US (1) US4150136A (es)
JP (1) JPS537681A (es)
AT (1) AT366369B (es)
CA (1) CA1094561A (es)
DE (1) DE2728831A1 (es)
DK (1) DK285077A (es)
ES (2) ES460371A1 (es)
FI (1) FI65242C (es)
FR (1) FR2357547A1 (es)
GB (1) GB1582783A (es)
IE (1) IE45241B1 (es)
IL (1) IL52449A (es)
MY (1) MY8400058A (es)
NL (1) NL7707307A (es)
NZ (1) NZ184547A (es)
PH (1) PH14074A (es)
PT (1) PT66758B (es)
SE (2) SE7707445L (es)
SU (1) SU692559A3 (es)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4678791A (en) * 1985-05-07 1987-07-07 Pennwalt Corporation 6-phenyl-1,2-3,4,4a,5-6,10b-octahydrobenz(h)isoquinolines useful for treating depression

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3325803A (en) * 1964-10-01 1967-06-13 Ibm Deflection control circuit

Also Published As

Publication number Publication date
DK285077A (da) 1978-01-07
FR2357547B1 (es) 1980-02-15
PT66758A (fr) 1977-08-01
FI771986A (es) 1978-01-07
FR2357547A1 (fr) 1978-02-03
IE45241L (en) 1978-01-06
GB1582783A (en) 1981-01-14
DE2728831A1 (de) 1978-01-19
SE8207394L (sv) 1982-12-23
IE45241B1 (en) 1982-07-14
ES476889A1 (es) 1979-07-16
AU2677177A (en) 1979-01-11
US4150136A (en) 1979-04-17
IL52449A0 (en) 1977-10-31
JPS537681A (en) 1978-01-24
PH14074A (en) 1981-01-26
ATA477577A (de) 1981-08-15
SE8207394D0 (sv) 1982-12-23
FI65242C (fi) 1984-04-10
NL7707307A (nl) 1978-01-10
AT366369B (de) 1982-04-13
SE7707445L (sv) 1978-01-07
NZ184547A (en) 1980-08-26
SU692559A3 (ru) 1979-10-15
FI65242B (fi) 1983-12-30
IL52449A (en) 1981-09-13
PT66758B (fr) 1979-03-12
CA1094561A (en) 1981-01-27
MY8400058A (en) 1984-12-31

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19990601