ES451242A1 - A procedure for the preparation of imidazoles. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

A procedure for the preparation of imidazoles of the formula **(See formula)** where R and R1 are independently selected from hydrogen, C1-C10 alkyl substituted with 1-3 substituents, aryl, aryl substituted with 1-5 substituents, a heterocyclic group of 5 or 6 ring atoms, halogen, cyano, carboxy and derivatives of carboxy and (see formula) where Ra is H or C1-C6 alkyl; R3 is aryl of 6 ring atoms of which 0 to 2 are not carbon atoms, aryl substituted with 1-4 substituents, ring aryl fused to 9 or 10 ring atoms of which 0 to 2 are not they are carbon atoms and fused ring aryl substituted with 1-4 substituents; R4 is selected from hydroxy and (see formula) where Rb is C1-C6 alkyl and R5 and R6, when separated, are independently selected from hydrogen, C1-C6 alkyl, and substituted C1-C6 alkyl and, when linked, form a 5- or 6-membered N-alicyclic ring; whose procedure is to react a compound of formula (b): **(See formula)** where L is halogen, in the presence of ammonia, which may optionally have been previously treated with a weak base with a compound of formula (a): **(See formula)** and optionally form the addition salts of organic or inorganic acids. (Machine-translation by Google Translate, not legally binding)