ES449557A1 - Procedure for preparation of polymethylene-4, 5 pirazoles. (Machine-translation by Google Translate, not legally binding) - Google Patents

Procedure for preparation of polymethylene-4, 5 pirazoles. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES449557A1
ES449557A1 ES449557A ES449557A ES449557A1 ES 449557 A1 ES449557 A1 ES 449557A1 ES 449557 A ES449557 A ES 449557A ES 449557 A ES449557 A ES 449557A ES 449557 A1 ES449557 A1 ES 449557A1
Authority
ES
Spain
Prior art keywords
formula
group
polymethylene
translation
procedure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES449557A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
RECH ENZYMOLOGIQUES SOC ET
Original Assignee
RECH ENZYMOLOGIQUES SOC ET
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by RECH ENZYMOLOGIQUES SOC ET filed Critical RECH ENZYMOLOGIQUES SOC ET
Publication of ES449557A1 publication Critical patent/ES449557A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/813—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/657—Unsaturated compounds containing a keto groups being part of a ring containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/782—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic
    • C07C49/792—Ketones containing a keto group bound to a six-membered aromatic ring polycyclic containing rings other than six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Procedure for the preparation of polymethylene-4,5-pyrazoles, which correspond to the following general formula: **(See formula)** in which: - R1 represents a hydrogen atom, an alkyl group comprising 1 to 4 carbon atoms, or a phenyl nucleus substituted by one or more halogen atoms or by two nitro groups, - R2 represents an alkyl group comprising from 1 to 4 carbon atoms, a cyclohexane group, a phenyl nucleus optionally substituted by an alkyl group comprising a maximum of 4 carbon atoms, a methoxy group or a halogen atom or a group benzyl, - R3 represents a hydrogen atom or a methyl group, and - n is equal to 3 or 4, however, the set (R1, R2, R3) cannot take the values (H, phenyl, H) and (H, methyl, H) when n = 4, characterized in that it consists of cycling a β-diketone that responds to the general formula (II): **(See formula)** in which n and R2 have the same meaning as in formula (I), due to the action of a hydrazine hydrate that responds to general formula (III): R1NH - NH2 H2O where R1 has the same meaning as in formula (I). (Machine-translation by Google Translate, not legally binding)
ES449557A 1975-07-03 1976-07-03 Procedure for preparation of polymethylene-4, 5 pirazoles. (Machine-translation by Google Translate, not legally binding) Expired ES449557A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR7520888A FR2315924A1 (en) 1975-07-03 1975-07-03 Analgesic and antiinflammatory polymethylene pyrazole derivs. - prepd. by cyclizing 2-acyl cyclic ketones with hydrazine derivs.

Publications (1)

Publication Number Publication Date
ES449557A1 true ES449557A1 (en) 1977-08-01

Family

ID=9157451

Family Applications (1)

Application Number Title Priority Date Filing Date
ES449557A Expired ES449557A1 (en) 1975-07-03 1976-07-03 Procedure for preparation of polymethylene-4, 5 pirazoles. (Machine-translation by Google Translate, not legally binding)

Country Status (3)

Country Link
DE (1) DE2630015C3 (en)
ES (1) ES449557A1 (en)
FR (1) FR2315924A1 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1986007357A2 (en) * 1985-06-14 1986-12-18 Upjohn Co Cyclopentapyrazole and tetrahydroindazole compounds
IT1287174B1 (en) * 1996-11-15 1998-08-04 Angelini Ricerche Spa PHARMACOLOGICALLY ACTIVE DIARYL-CYCLOMETHYLENPYRAZOLES, PROCEDURE FOR PREPARING THEM AND PHARMACEUTICAL COMPOSITIONS THAT CONTAIN THEM
US6083969A (en) * 1999-10-20 2000-07-04 Ortho-Mcneil Pharaceutical, Inc. 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as selective inhibitors of cyclooxygenase-2 and antiinflammatory agents
RU2485105C1 (en) * 2012-03-28 2013-06-20 Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Пермский государственный национальный исследовательский университет" 3-(3,4-dimethoxyphenyl)-4,5,6,7-tetrahydroindazole hydrochloride, analgesic and antimicrobial agent

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1948793A1 (en) * 1969-09-26 1971-04-01 Rhein Chemie Rheinau Gmbh Process for the preparation of 4,5,6,7-tetrahydroindazoles

Also Published As

Publication number Publication date
FR2315924A1 (en) 1977-01-28
DE2630015C3 (en) 1981-07-30
DE2630015A1 (en) 1977-01-27
FR2315924B1 (en) 1978-10-06
DE2630015B2 (en) 1980-10-16

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