ES449362A1 - Secondary acyloxy compounds - Google Patents
Secondary acyloxy compoundsInfo
- Publication number
- ES449362A1 ES449362A1 ES449362A ES449362A ES449362A1 ES 449362 A1 ES449362 A1 ES 449362A1 ES 449362 A ES449362 A ES 449362A ES 449362 A ES449362 A ES 449362A ES 449362 A1 ES449362 A1 ES 449362A1
- Authority
- ES
- Spain
- Prior art keywords
- compounds
- acyl
- novel compounds
- cycloaliphatic
- novel
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 125000004423 acyloxy group Chemical group 0.000 title 1
- 150000001875 compounds Chemical class 0.000 abstract 5
- 125000002252 acyl group Chemical group 0.000 abstract 3
- 125000001931 aliphatic group Chemical group 0.000 abstract 2
- 239000004215 Carbon black (E152) Substances 0.000 abstract 1
- AVXURJPOCDRRFD-UHFFFAOYSA-N Hydroxylamine Chemical class ON AVXURJPOCDRRFD-UHFFFAOYSA-N 0.000 abstract 1
- 125000003118 aryl group Chemical group 0.000 abstract 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 abstract 1
- 239000002368 cardiac glycoside Substances 0.000 abstract 1
- 229940097217 cardiac glycoside Drugs 0.000 abstract 1
- 239000000496 cardiotonic agent Substances 0.000 abstract 1
- 230000003177 cardiotonic effect Effects 0.000 abstract 1
- 230000005792 cardiovascular activity Effects 0.000 abstract 1
- 230000002057 chronotropic effect Effects 0.000 abstract 1
- -1 cycloaliphatic Chemical group 0.000 abstract 1
- 230000032050 esterification Effects 0.000 abstract 1
- 238000005886 esterification reaction Methods 0.000 abstract 1
- 229930195733 hydrocarbon Natural products 0.000 abstract 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 1
- 239000001257 hydrogen Substances 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 230000002107 myocardial effect Effects 0.000 abstract 1
- 239000000825 pharmaceutical preparation Substances 0.000 abstract 1
- 230000000144 pharmacologic effect Effects 0.000 abstract 1
- 230000009090 positive inotropic effect Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229930002534 steroid glycoside Natural products 0.000 abstract 1
- 150000008143 steroidal glycosides Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C11—ANIMAL OR VEGETABLE OILS, FATS, FATTY SUBSTANCES OR WAXES; FATTY ACIDS THEREFROM; DETERGENTS; CANDLES
- C11D—DETERGENT COMPOSITIONS; USE OF SINGLE SUBSTANCES AS DETERGENTS; SOAP OR SOAP-MAKING; RESIN SOAPS; RECOVERY OF GLYCEROL
- C11D17/00—Detergent materials or soaps characterised by their shape or physical properties
- C11D17/0047—Detergents in the form of bars or tablets
- C11D17/0065—Solid detergents containing builders
- C11D17/0073—Tablets
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C219/00—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C219/02—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C219/04—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C219/06—Compounds containing amino and esterified hydroxy groups bound to the same carbon skeleton having esterified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having the hydroxy groups esterified by carboxylic acids having the esterifying carboxyl groups bound to hydrogen atoms or to acyclic carbon atoms of an acyclic saturated carbon skeleton
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Wood Science & Technology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
There are prepared novel secondary acyloxyamines of the formula < IMAGE > in which Z1 represents hydrogen or acyl and Z2 represents acyl, where acyl denotes the radical of an aliphatic, cycloaliphatic, aromatic or araliphatic carboxylic acid, and R1 represents an optionally substituted aliphatic, cycloaliphatic or araliphatic hydrocarbon radical, or their salts. These compounds are obtained in a manner known per se by esterification of corresponding hydroxyamines. The novel compounds in particular have cardioselective beta -receptor-stimulating actions of a long duration of action. The novel compounds thus have a positive chronotropic and in particular a positive inotropic action. These pharmacological activities characterise the novel compounds as cardiotonics, which can be used alone or in combination with other compounds having cardiovascular activity, e.g. cardiac glycosides, in the form of pharmaceutical preparations for the treatment of myocardial insufficiency.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CH854075A CH618958A5 (en) | 1975-07-01 | 1975-07-01 | Process for the preparation of novel secondary acyloxyamines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES449362A1 true ES449362A1 (en) | 1977-08-01 |
Family
ID=4341730
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES449362A Expired ES449362A1 (en) | 1975-07-01 | 1976-06-30 | Secondary acyloxy compounds |
Country Status (17)
| Country | Link |
|---|---|
| JP (1) | JPS527931A (en) |
| AT (1) | AT345801B (en) |
| AU (1) | AU499045B2 (en) |
| BE (1) | BE843675A (en) |
| CA (1) | CA1090369A (en) |
| CH (1) | CH618958A5 (en) |
| DE (1) | DE2628877A1 (en) |
| DK (1) | DK293476A (en) |
| ES (1) | ES449362A1 (en) |
| FI (1) | FI761877A (en) |
| FR (1) | FR2315919A1 (en) |
| GB (1) | GB1511090A (en) |
| IL (1) | IL49942A0 (en) |
| NL (1) | NL7607193A (en) |
| NO (1) | NO143101B (en) |
| SE (1) | SE7607464L (en) |
| ZA (1) | ZA763901B (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4210653A (en) * | 1978-06-27 | 1980-07-01 | Merck & Co., Inc. | Pyridyloxypropanolamines |
| DE3625738A1 (en) * | 1986-07-30 | 1988-02-11 | Goedecke Ag | 2-ACYLOXYPROPYLAMINE DERIVATIVES, METHOD FOR THE PRODUCTION AND THEIR USE |
-
1975
- 1975-07-01 CH CH854075A patent/CH618958A5/en not_active IP Right Cessation
-
1976
- 1976-06-26 DE DE19762628877 patent/DE2628877A1/en active Pending
- 1976-06-28 FR FR7619589A patent/FR2315919A1/en active Granted
- 1976-06-29 FI FI761877A patent/FI761877A/fi not_active Application Discontinuation
- 1976-06-29 GB GB26986/76A patent/GB1511090A/en not_active Expired
- 1976-06-29 CA CA255,950A patent/CA1090369A/en not_active Expired
- 1976-06-30 SE SE7607464A patent/SE7607464L/en unknown
- 1976-06-30 DK DK293476A patent/DK293476A/en unknown
- 1976-06-30 AU AU15440/76A patent/AU499045B2/en not_active Expired
- 1976-06-30 ZA ZA00763901A patent/ZA763901B/en unknown
- 1976-06-30 ES ES449362A patent/ES449362A1/en not_active Expired
- 1976-06-30 NL NL7607193A patent/NL7607193A/en not_active Application Discontinuation
- 1976-06-30 IL IL49942A patent/IL49942A0/en unknown
- 1976-06-30 NO NO762268A patent/NO143101B/en unknown
- 1976-06-30 AT AT476776A patent/AT345801B/en not_active IP Right Cessation
- 1976-07-01 BE BE168546A patent/BE843675A/en unknown
- 1976-07-01 JP JP51077113A patent/JPS527931A/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CA1090369A (en) | 1980-11-25 |
| FR2315919A1 (en) | 1977-01-28 |
| NO762268L (en) | 1977-01-04 |
| AU1544076A (en) | 1978-01-05 |
| IL49942A0 (en) | 1976-08-31 |
| DK293476A (en) | 1977-01-02 |
| AU499045B2 (en) | 1979-04-05 |
| FI761877A (en) | 1977-01-02 |
| JPS527931A (en) | 1977-01-21 |
| GB1511090A (en) | 1978-05-17 |
| NL7607193A (en) | 1977-01-04 |
| FR2315919B1 (en) | 1978-11-17 |
| SE7607464L (en) | 1977-01-02 |
| NO143101B (en) | 1980-09-08 |
| AT345801B (en) | 1978-10-10 |
| ATA476776A (en) | 1978-02-15 |
| DE2628877A1 (en) | 1977-01-20 |
| CH618958A5 (en) | 1980-08-29 |
| BE843675A (en) | 1977-01-03 |
| ZA763901B (en) | 1978-02-22 |
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