ES445169A1 - Procedure for the preparation of new eteres oximas and its quaternary ammonium derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

Abstract

Procedure for the preparation of new oxime ethers and their quaternary ammonium derivatives, the new oxime ethers being of general formula **(See formula)** wherein R represents a phenyl radical which can be substituted by a halogen atom or by one or more C1-C4 alkoxy, hydroxy, nitros or di (C1-C3 alkyl) amino groups; R1 and R2 indicate one hydrogen atom each or together a valence bond; A represents a C2-C4 straight or branched chain alkylene group; B indicates an amino or di (C1-4alkyl) -amino group or a group of general formula VII: **(See formula)** wherein R3 and R4 together denote a C4-C7 alkylene chain also containing another oxygen or nitrogen heteroatom and the latter may also carry a benzyl or C1-C3 alkyl substitute; and n represents an integer from 3 to 10; characterized in that a compound of the general formula IX is reacted: **(See formula)** in which the meaning of R, R and R is the same as that already mentioned and 2 represents a group = C = Y, a group -CH = CCI- or a group = C = N - OH, Y having the meaning above indicated, it was reacted with a compound of the general formula X: D - A'' - E where A'' represents a straight or branched chain alkylene group, D has the same meaning assigned above to β or represents a Halogen atom, and E represents an aminoxy group, a Halogen atom or a methylene halogen group, Proceeding, if desired, to the amination of the halogenated alkyl ether thus obtained and, if desired and possible, the conversion of the compound obtained of general formula I into a therapeutically tolerable acidic addition salt or a quaternary ammonium derivative, or if desired, upon the release of the base of a compound of general formula I obtained in the form of a salt. (Machine-translation by Google Translate, not legally binding)