ES442779A1 - 33 furuoro dd aranin oyobi 22 juuteroo33 furuoro dd araninnofuseigoseiho - Google Patents

33 furuoro dd aranin oyobi 22 juuteroo33 furuoro dd araninnofuseigoseiho

Info

Publication number
ES442779A1
ES442779A1 ES442779A ES442779A ES442779A1 ES 442779 A1 ES442779 A1 ES 442779A1 ES 442779 A ES442779 A ES 442779A ES 442779 A ES442779 A ES 442779A ES 442779 A1 ES442779 A1 ES 442779A1
Authority
ES
Spain
Prior art keywords
alanine
furuoro
fluoro
reacting
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES442779A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US05/525,708 external-priority patent/US3976689A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of ES442779A1 publication Critical patent/ES442779A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B53/00—Asymmetric syntheses
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
    • A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C07B59/001—Acyclic or carbocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/20—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated the carbon skeleton being further substituted by halogen atoms or by nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/05—Isotopically modified compounds, e.g. labelled

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Pest Control & Pesticides (AREA)
  • Plant Pathology (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Dentistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Indole Compounds (AREA)

Abstract

A process for the preparation of alanine derivatives which consists in reacting pyruvic fluorine acid with an optically active d-amine, thus forming the corresponding d-ketimine, reacting the latter with an alkali metal borohydride or an alkaline metal borodeuteride for thus reducing the ketimine and forming the corresponding N-substituted 3-fluoro-d-alanine or N-substituted 2-deutero-3-fluoro-d-alanine and reacting said N-substituted compound with hydrogen, in the presence of a hydrogenation constituted by palladium hydroxide in carbon, thus hydrogenolizing the N-substituent to form 3-fluoro-d-alanine or 2-deutero-3-fluoro-d-alanine. (Machine-translation by Google Translate, not legally binding)
ES442779A 1974-11-20 1975-11-18 33 furuoro dd aranin oyobi 22 juuteroo33 furuoro dd araninnofuseigoseiho Expired ES442779A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US05/525,708 US3976689A (en) 1972-02-03 1974-11-20 Process for preparing 3-fluoro-D-alanine and its deutero analogs

Publications (1)

Publication Number Publication Date
ES442779A1 true ES442779A1 (en) 1977-09-16

Family

ID=24094311

Family Applications (1)

Application Number Title Priority Date Filing Date
ES442779A Expired ES442779A1 (en) 1974-11-20 1975-11-18 33 furuoro dd aranin oyobi 22 juuteroo33 furuoro dd araninnofuseigoseiho

Country Status (9)

Country Link
JP (1) JPS5175020A (en)
CH (1) CH619685A5 (en)
DD (1) DD124972A5 (en)
DK (1) DK515575A (en)
ES (1) ES442779A1 (en)
FI (1) FI753167A (en)
NL (1) NL7513137A (en)
NO (1) NO753750L (en)
SE (1) SE7512699L (en)

Also Published As

Publication number Publication date
JPS5175020A (en) 1976-06-29
CH619685A5 (en) 1980-10-15
NO753750L (en) 1976-05-21
FI753167A (en) 1976-05-21
DK515575A (en) 1976-05-21
DD124972A5 (en) 1977-03-23
NL7513137A (en) 1976-05-24
SE7512699L (en) 1976-05-21

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