ES436328A1 - A procedure for the production of cefalosporine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the production of cefalosporine derivatives. (Machine-translation by Google Translate, not legally binding)

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Publication number
ES436328A1
ES436328A1 ES436328A ES436328A ES436328A1 ES 436328 A1 ES436328 A1 ES 436328A1 ES 436328 A ES436328 A ES 436328A ES 436328 A ES436328 A ES 436328A ES 436328 A1 ES436328 A1 ES 436328A1
Authority
ES
Spain
Prior art keywords
group
formula
given above
hydrogen atom
meaning given
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES436328A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Yamanouchi Pharmaceutical Co Ltd
Original Assignee
Yamanouchi Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP49038545A external-priority patent/JPS5953276B2/en
Priority claimed from JP4188474A external-priority patent/JPS50140480A/ja
Priority claimed from JP6312474A external-priority patent/JPS50154282A/ja
Priority claimed from JP6477474A external-priority patent/JPS604191B2/en
Application filed by Yamanouchi Pharmaceutical Co Ltd filed Critical Yamanouchi Pharmaceutical Co Ltd
Publication of ES436328A1 publication Critical patent/ES436328A1/en
Expired legal-status Critical Current

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  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

A process for the production of cephalosporin derivatives represented by the formula: **(See formula)** where R represents a hydrogen atom or a hydroxy group; A represents a 5- or 6-membered ring containing 1 or 2 nitrogen atoms, a quinoline ring, or a thiopyran ring; R1 and S1, which may be the same or different, each represent a hydrogen atom, a hydroxy group, a lower alkyl group, a lower alkoxy group, a lower alkylthio group or an oxo group; B represents a 5-membered ring containing 1 to 4 nitrogen atoms and/or 0-1 sulfur atoms, a 5-membered ring with 2 nitrogen atoms, or a 1, 2, 4-thiazolo- [3, 4- b] -1, 3, 4-thiadiazole; R3 and R4, when present, may be the same or different and each represents a hydrogen atom, an oxo group, a lower alkyl group or an amino group; D represents a sulfur atom or a group -NH-CO-; E represents an alkylene group or a phenylene group; G represents a carboxy group or a sulfo group; n is 0 or 1 when m is 0 and n is 1 when m is 1; and the pharmacologically acceptable salts of these derivatives; whose procedure consists of reacting a compound represented by the formula: **(See formula)** where R has the meaning given above and a heterocyclic carbocyclic acid represented by the formula: **(See formula)** where A, R1 and R2 have the meaning given above, or a reactive derivative thereof, to produce the compound represented by the formula: **(See formula)** where A, R, R1 and R2 have the meaning given above and then react the product with a mercapto-heterocyclic compound represented by the formula: **(See formula)** where M represents a hydrogen atom or an alkali metal atom and R3, R4, B, D, E, G, m and n have the meaning given above. (Machine-translation by Google Translate, not legally binding)
ES436328A 1974-04-05 1975-04-04 A procedure for the production of cefalosporine derivatives. (Machine-translation by Google Translate, not legally binding) Expired ES436328A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP49038545A JPS5953276B2 (en) 1974-04-05 1974-04-05 Method for producing new cephalosporin derivatives
JP4188474A JPS50140480A (en) 1974-04-15 1974-04-15
JP6312474A JPS50154282A (en) 1974-06-04 1974-06-04
JP6477474A JPS604191B2 (en) 1974-06-07 1974-06-07 Method for synthesizing new cephalosporanic acid derivatives

Publications (1)

Publication Number Publication Date
ES436328A1 true ES436328A1 (en) 1977-05-16

Family

ID=27460631

Family Applications (1)

Application Number Title Priority Date Filing Date
ES436328A Expired ES436328A1 (en) 1974-04-05 1975-04-04 A procedure for the production of cefalosporine derivatives. (Machine-translation by Google Translate, not legally binding)

Country Status (1)

Country Link
ES (1) ES436328A1 (en)

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