ES436328A1 - A procedure for the production of cefalosporine derivatives. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the production of cefalosporine derivatives. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES436328A1 ES436328A1 ES436328A ES436328A ES436328A1 ES 436328 A1 ES436328 A1 ES 436328A1 ES 436328 A ES436328 A ES 436328A ES 436328 A ES436328 A ES 436328A ES 436328 A1 ES436328 A1 ES 436328A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- given above
- hydrogen atom
- meaning given
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Landscapes
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
A process for the production of cephalosporin derivatives represented by the formula: **(See formula)** where R represents a hydrogen atom or a hydroxy group; A represents a 5- or 6-membered ring containing 1 or 2 nitrogen atoms, a quinoline ring, or a thiopyran ring; R1 and S1, which may be the same or different, each represent a hydrogen atom, a hydroxy group, a lower alkyl group, a lower alkoxy group, a lower alkylthio group or an oxo group; B represents a 5-membered ring containing 1 to 4 nitrogen atoms and/or 0-1 sulfur atoms, a 5-membered ring with 2 nitrogen atoms, or a 1, 2, 4-thiazolo- [3, 4- b] -1, 3, 4-thiadiazole; R3 and R4, when present, may be the same or different and each represents a hydrogen atom, an oxo group, a lower alkyl group or an amino group; D represents a sulfur atom or a group -NH-CO-; E represents an alkylene group or a phenylene group; G represents a carboxy group or a sulfo group; n is 0 or 1 when m is 0 and n is 1 when m is 1; and the pharmacologically acceptable salts of these derivatives; whose procedure consists of reacting a compound represented by the formula: **(See formula)** where R has the meaning given above and a heterocyclic carbocyclic acid represented by the formula: **(See formula)** where A, R1 and R2 have the meaning given above, or a reactive derivative thereof, to produce the compound represented by the formula: **(See formula)** where A, R, R1 and R2 have the meaning given above and then react the product with a mercapto-heterocyclic compound represented by the formula: **(See formula)** where M represents a hydrogen atom or an alkali metal atom and R3, R4, B, D, E, G, m and n have the meaning given above. (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP49038545A JPS5953276B2 (en) | 1974-04-05 | 1974-04-05 | Method for producing new cephalosporin derivatives |
JP4188474A JPS50140480A (en) | 1974-04-15 | 1974-04-15 | |
JP6312474A JPS50154282A (en) | 1974-06-04 | 1974-06-04 | |
JP6477474A JPS604191B2 (en) | 1974-06-07 | 1974-06-07 | Method for synthesizing new cephalosporanic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
ES436328A1 true ES436328A1 (en) | 1977-05-16 |
Family
ID=27460631
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES436328A Expired ES436328A1 (en) | 1974-04-05 | 1975-04-04 | A procedure for the production of cefalosporine derivatives. (Machine-translation by Google Translate, not legally binding) |
Country Status (1)
Country | Link |
---|---|
ES (1) | ES436328A1 (en) |
-
1975
- 1975-04-04 ES ES436328A patent/ES436328A1/en not_active Expired
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