ES434593A1 - Procedure for the obtaining of beneflpenicilinas alfasustituidas. (Machine-translation by Google Translate, not legally binding)
- Google Patents
Procedure for the obtaining of beneflpenicilinas alfasustituidas. (Machine-translation by Google Translate, not legally binding)
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Tresquim S A
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Tresquim S A
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Low-Molecular Organic Synthesis Reactions Using Catalysts
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Abstract
Process for obtaining alpha-substituted benzylpenicillins, of the general formula ** (see formula) ** Wherein m and m1, independently of one another, mean hydrogen, sodium or potassium, characterized in that, in a first phase, the benzyl monoester of phenyl malonic acid is reacted with thionyl chloride, forming the corresponding acid chloride, according to the reaction scheme ** (see formula) ** In a second phase, the above-mentioned intermediate compound is condensed with the alkali salt of 6-amino-pyriclanic acid, according to the equation ** (see formula) ** And the (alpha-phenyl-alpha-benzylcarboxylate) -6-acetamido-penicillanic acid, resulting from the above reaction, is transformed, in a third phase of the process, into its alkaline salt, which is hydrogenated in aqueous medium under palladium catalyst, according to the reaction scheme ** (see formula) ** Optionally completing the reaction until the formation of the dialkaline salt, raising the ph of the solution formed in the previous phase with the corresponding alkali hydroxide and finally lyophilizing the resulting solution. (Machine-translation by Google Translate, not legally binding)
ES434593A1975-02-101975-02-10Procedure for the obtaining of beneflpenicilinas alfasustituidas. (Machine-translation by Google Translate, not legally binding)
ExpiredES434593A1
(en)
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