ES434590A1 - Analogues of prostanoic acids and process for preparing them - Google Patents

Analogues of prostanoic acids and process for preparing them

Info

Publication number
ES434590A1
ES434590A1 ES434590A ES434590A ES434590A1 ES 434590 A1 ES434590 A1 ES 434590A1 ES 434590 A ES434590 A ES 434590A ES 434590 A ES434590 A ES 434590A ES 434590 A1 ES434590 A1 ES 434590A1
Authority
ES
Spain
Prior art keywords
compounds
analogues
action
group
prostanoic acids
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES434590A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2407186A external-priority patent/DE2407186C2/en
Priority claimed from DE19742445526 external-priority patent/DE2445526A1/en
Application filed by Hoechst AG filed Critical Hoechst AG
Publication of ES434590A1 publication Critical patent/ES434590A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D339/00—Heterocyclic compounds containing rings having two sulfur atoms as the only ring hetero atoms
    • C07D339/02—Five-membered rings
    • C07D339/06—Five-membered rings having the hetero atoms in positions 1 and 3, e.g. cyclic dithiocarbonates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C405/00—Compounds containing a five-membered ring having two side-chains in ortho position to each other, and having oxygen atoms directly attached to the ring in ortho position to one of the side-chains, one side-chain containing, not directly attached to the ring, a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, and the other side-chain having oxygen atoms attached in gamma-position to the ring, e.g. prostaglandins ; Analogues or derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/56—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds from heterocyclic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/65—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups
    • C07C45/66—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by splitting-off hydrogen atoms or functional groups; by hydrogenolysis of functional groups by dehydration
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Novel analogues of prostanoic acids, which have the accompanying formula I, in which the symbols R1 to R3 have the meaning given in Patent Claim 1, are prepared by removing the tetrahydropyranyl ether protective group and the ketal grouping simultaneously or successively from an appropriately substituted 3-tetrahydropyranyloxy- 1,5-dioxaspiro compound. The corresponding compounds in which, instead of the keto group in the cyclopentyl radical, hydrogen and a hydroxy group are present, are obtained by reduction with a complex metal hydride. The compounds can then be converted into their physiologically tolerable salts or esters. The compounds are distinguished, even in the form of their epimer mixtures, by a good general spasmolytic, in particular bronchodilatory, action. They additionally have a hypotensive action and can also be employed in some cases in gastrointestinal disorders.
ES434590A 1974-02-15 1975-02-10 Analogues of prostanoic acids and process for preparing them Expired ES434590A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE2407186A DE2407186C2 (en) 1974-02-15 1974-02-15 New, naturally non-occurring analogs of prostanoic acids and processes for their preparation, as well as pharmaceuticals containing these analogs of prostanoic acids
DE19742445526 DE2445526A1 (en) 1974-09-24 1974-09-24 7-(2-(3-Hydroxy-1-propenyl)-5-oxocyclopentyl)-4-heptenoic acids - prostaglandin analogues with bronchodilatory, hypotensive, etc., activity

Publications (1)

Publication Number Publication Date
ES434590A1 true ES434590A1 (en) 1977-04-01

Family

ID=25766631

Family Applications (2)

Application Number Title Priority Date Filing Date
ES434590A Expired ES434590A1 (en) 1974-02-15 1975-02-10 Analogues of prostanoic acids and process for preparing them
ES452901A Expired ES452901A1 (en) 1974-02-15 1976-10-30 Analogues of prostanoic acids and process for preparing them

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES452901A Expired ES452901A1 (en) 1974-02-15 1976-10-30 Analogues of prostanoic acids and process for preparing them

Country Status (13)

Country Link
JP (1) JPS5854139B2 (en)
CA (1) CA1042003A (en)
CH (1) CH617675A5 (en)
DK (1) DK55575A (en)
ES (2) ES434590A1 (en)
FR (1) FR2261004B1 (en)
GB (1) GB1507501A (en)
HU (1) HU174323B (en)
IE (1) IE41407B1 (en)
IL (1) IL46615A0 (en)
LU (1) LU71837A1 (en)
NL (1) NL7501560A (en)
SE (1) SE7501653L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4387241A (en) * 1974-11-01 1983-06-07 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives
US4032561A (en) * 1975-05-27 1977-06-28 The Upjohn Company 17-Phenyl-18,19,20-trinor-cis-4,5-didehydro-PGF1.sub.α compounds
ZA771725B (en) * 1976-04-21 1978-02-22 Upjohn Co Ayal prostaglandin analogs
US4228296A (en) * 1979-01-24 1980-10-14 American Cyanamid Company Novel 16-aryloxy-17,18,19,20-tetranorprostanoic acids and derivatives

Also Published As

Publication number Publication date
FR2261004A1 (en) 1975-09-12
SE7501653L (en) 1975-08-18
GB1507501A (en) 1978-04-19
JPS5854139B2 (en) 1983-12-02
JPS50123644A (en) 1975-09-29
IL46615A0 (en) 1975-04-25
FR2261004B1 (en) 1978-07-21
CA1042003A (en) 1978-11-07
HU174323B (en) 1979-12-28
NL7501560A (en) 1975-08-19
LU71837A1 (en) 1977-01-05
IE41407L (en) 1975-08-15
AU7817775A (en) 1976-08-19
IE41407B1 (en) 1980-01-02
ES452901A1 (en) 1977-11-01
DK55575A (en) 1975-10-13
CH617675A5 (en) 1980-06-13

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