ES430658A1 - Cephalosporin derivatives and the preparation thereof - Google Patents

Cephalosporin derivatives and the preparation thereof

Info

Publication number
ES430658A1
ES430658A1 ES430658A ES430658A ES430658A1 ES 430658 A1 ES430658 A1 ES 430658A1 ES 430658 A ES430658 A ES 430658A ES 430658 A ES430658 A ES 430658A ES 430658 A1 ES430658 A1 ES 430658A1
Authority
ES
Spain
Prior art keywords
alkyl
denotes
denotes hydrogen
aryl
alkylthio
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES430658A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Fujisawa Pharmaceutical Co Ltd
Original Assignee
Fujisawa Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP11168573A external-priority patent/JPS5715596B2/ja
Priority claimed from JP11168473A external-priority patent/JPS5652910B2/ja
Priority claimed from JP11168673A external-priority patent/JPS5062990A/ja
Priority claimed from JP11493273A external-priority patent/JPS5716117B2/ja
Application filed by Fujisawa Pharmaceutical Co Ltd filed Critical Fujisawa Pharmaceutical Co Ltd
Priority to ES450400A priority Critical patent/ES450400A1/en
Publication of ES430658A1 publication Critical patent/ES430658A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D285/00—Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
    • C07D285/01—Five-membered rings
    • C07D285/02—Thiadiazoles; Hydrogenated thiadiazoles
    • C07D285/04—Thiadiazoles; Hydrogenated thiadiazoles not condensed with other rings
    • C07D285/12—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
    • C07D285/125—1,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Cephalosporin Compounds (AREA)

Abstract

Novel derivatives of the cephalosporin series of the formula I < IMAGE > in which R1 denotes hydrogen, hydroxy(lower)alkylthio or heterocyclic thio which is optionally substituted by a lower alkyl or alkanoyloxy(lower)alkyl, R2 denotes lower alkyl, lower alkylthio(lower)alkyl, acyl(lower)alkyl, acylamino(lower)alkyl, lower alkenyl, aryl(lower)alkenyl or lower alkynyl, R3 denotes hydrogen, lower alkyl or aryl and X denotes sulphur or sulphinyl, but R2 cannot be lower alkyl if R1 denotes hydrogen, and their esters, amides and acid anhydrides on the carboxyl group are obtained by N-acylation of a corresponding 7-amino-3-cephem-4-carboxylic acid or a corresponding derivative with a carboxylic acid R2XCH(R3)COOH or a reactive derivative thereof. The compounds and their salts have a high antibacterial action and are suitable for the treatment of infectious diseases in humans and animals.
ES430658A 1973-10-03 1974-10-03 Cephalosporin derivatives and the preparation thereof Expired ES430658A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
ES450400A ES450400A1 (en) 1973-10-12 1976-08-02 A procedure for preparing an acid derivative 7- (acetamido, substituted in alpha) -3-methyl-3-cefem-4-carboxylic. (Machine-translation by Google Translate, not legally binding)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP11168573A JPS5715596B2 (en) 1973-10-03 1973-10-03
JP11168473A JPS5652910B2 (en) 1973-10-03 1973-10-03
JP11168673A JPS5062990A (en) 1973-10-03 1973-10-03
JP11493273A JPS5716117B2 (en) 1973-10-12 1973-10-12

Publications (1)

Publication Number Publication Date
ES430658A1 true ES430658A1 (en) 1977-04-01

Family

ID=27469929

Family Applications (1)

Application Number Title Priority Date Filing Date
ES430658A Expired ES430658A1 (en) 1973-10-03 1974-10-03 Cephalosporin derivatives and the preparation thereof

Country Status (14)

Country Link
AR (1) AR207960A1 (en)
CH (1) CH610901A5 (en)
DD (1) DD114086A5 (en)
DE (1) DE2447194A1 (en)
DK (1) DK518874A (en)
ES (1) ES430658A1 (en)
FI (1) FI287774A (en)
FR (1) FR2247247B1 (en)
GB (1) GB1488679A (en)
HU (1) HU168771B (en)
IE (1) IE40528B1 (en)
NO (1) NO743582L (en)
PH (1) PH14343A (en)
SE (1) SE7412429L (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS52125184A (en) 1976-03-04 1977-10-20 Toyo Jozo Co Ltd Novel cephalosporin compounds
DE2655949A1 (en) * 1976-12-10 1978-06-15 Gruenenthal Gmbh NEW CEPHALOSPORIN AND PENICILLIN DERIVATIVES, PROCESS FOR THEIR MANUFACTURING AND MEDICINAL PRODUCTS CONTAINING THESE PRODUCTS
WO2010118361A1 (en) * 2009-04-09 2010-10-14 Sopharmia, Inc. Beta lactamase inhibitors
CA2905240A1 (en) 2013-03-12 2014-10-09 Gladius Pharmaceuticals Coproration Derivatized 3-styryl-cephalosporins

Also Published As

Publication number Publication date
IE40528B1 (en) 1979-06-20
FR2247247A1 (en) 1975-05-09
AR207960A1 (en) 1976-11-22
PH14343A (en) 1981-06-03
FR2247247B1 (en) 1978-07-28
DK518874A (en) 1975-06-09
CH610901A5 (en) 1979-05-15
IE40528L (en) 1975-04-03
GB1488679A (en) 1977-10-12
SE7412429L (en) 1975-04-04
DE2447194A1 (en) 1975-04-10
FI287774A (en) 1975-04-04
DD114086A5 (en) 1975-07-12
AU7397474A (en) 1976-04-08
HU168771B (en) 1976-07-28
NO743582L (en) 1975-04-28

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