ES427715A2 - Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation - Google Patents
Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparationInfo
- Publication number
- ES427715A2 ES427715A2 ES427715A ES427715A ES427715A2 ES 427715 A2 ES427715 A2 ES 427715A2 ES 427715 A ES427715 A ES 427715A ES 427715 A ES427715 A ES 427715A ES 427715 A2 ES427715 A2 ES 427715A2
- Authority
- ES
- Spain
- Prior art keywords
- deoxy
- c22h24n2o8
- hpo3
- compounds
- complexes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
Alkali metal polyphosphate complexes of alpha -6-deoxy-5-hydroxytetracycline are prepared which have the formula (C22H24N2O8)z . (MePO3)x . (HPO3 )y in which Me is sodium or potassium, z = 1 to 5, x = 1 to 5, y = 1 to 5, x + y </= 6 and z </= y. The compounds are obtained by reacting metaphosphoric acid in an organic medium which is inert to the reaction with 1 to 5 mol of alpha -6-deoxy-5-hydroxytetracycline. The remaining free acid groups of the metaphosphoric acid are then neutralised with a methanolic or ethanolic solution of sodium hydroxide or potassium hydroxide in the stoichiometric quantity. The complex formed in this process is then precipitated by addition of a non-solvent which is inert to the reaction. Preferred compounds are the ethanol/water solvate of the complex of the formula C22H24N2O8 . NaPO3 . (HPO3)5 and C22H24N2O8 . (NaPO3)2 . (HPO3)4. The said compounds have an antibiotic activity, and they are very highly tolerable.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT5470870 | 1970-10-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES427715A2 true ES427715A2 (en) | 1977-02-16 |
Family
ID=20081722
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES396132A Expired ES396132A1 (en) | 1970-10-30 | 1971-10-19 | Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation |
| ES427715A Expired ES427715A2 (en) | 1970-10-30 | 1974-06-27 | Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES396132A Expired ES396132A1 (en) | 1970-10-30 | 1971-10-19 | Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation |
Country Status (18)
| Country | Link |
|---|---|
| JP (2) | JPS5510576B1 (en) |
| AT (2) | AT312166B (en) |
| AU (2) | AU473909B2 (en) |
| BE (2) | BE774717A (en) |
| CA (2) | CA988081A (en) |
| CH (2) | CH593239A5 (en) |
| DE (2) | DE2152476A1 (en) |
| DK (2) | DK152118C (en) |
| ES (2) | ES396132A1 (en) |
| FI (2) | FI54799C (en) |
| FR (2) | FR2111952B1 (en) |
| GB (1) | GB1463726A (en) |
| HK (1) | HK79079A (en) |
| IL (2) | IL38014A (en) |
| NL (2) | NL152248B (en) |
| NO (1) | NO140718C (en) |
| SE (2) | SE380518B (en) |
| ZA (2) | ZA717214B (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES396132A1 (en) * | 1970-10-30 | 1972-12-01 | Villax | Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation |
| GB1350196A (en) * | 1972-10-26 | 1974-04-18 | Pfizer | Doxycyline parenteral composition |
| PT72107B (en) * | 1980-11-25 | 1981-10-28 | Joao Emerico Villax | PROCESS FOR PREPARING A WATER SOLUBLE COMPLEX OF ALPHA-6-DIOXI-5-HYDROXITETRACYCLINE AND DESODIUM TETRAMETAPHOSPHATE |
| CN114276271A (en) * | 2021-11-22 | 2022-04-05 | 新乡医学院三全学院 | Method for preparing doxycycline hydrochloride solid powder with different granularities |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1068701B (en) * | 1959-11-12 | Bristol Laboratories Inc., East Syracuse, N. Y. (V. St. A.) | Process for the preparation of antibiotic tetracycline sodium hexametaphosphate | |
| US3068264A (en) * | 1961-06-06 | 1962-12-11 | American Cyanamid Co | Tetracycline antibiotic-aluminumphosphoric acid complexes |
| ES396132A1 (en) * | 1970-10-30 | 1972-12-01 | Villax | Complexes of a-6-deoxy-5-hydroxy tetracycline and their preparation |
-
1971
- 1971-10-19 ES ES396132A patent/ES396132A1/en not_active Expired
- 1971-10-21 DE DE19712152476 patent/DE2152476A1/en active Pending
- 1971-10-25 DK DK516671A patent/DK152118C/en not_active IP Right Cessation
- 1971-10-26 IL IL38014A patent/IL38014A/en unknown
- 1971-10-26 NL NL717114749A patent/NL152248B/en not_active IP Right Cessation
- 1971-10-26 SE SE7113551A patent/SE380518B/en unknown
- 1971-10-26 CH CH1558071A patent/CH593239A5/xx not_active IP Right Cessation
- 1971-10-27 NO NO3985/71A patent/NO140718C/en unknown
- 1971-10-27 CA CA126,250A patent/CA988081A/en not_active Expired
- 1971-10-27 FI FI3060/71A patent/FI54799C/en active
- 1971-10-28 ZA ZA717214A patent/ZA717214B/en unknown
- 1971-10-28 FR FR7138787A patent/FR2111952B1/fr not_active Expired
- 1971-10-29 BE BE774717A patent/BE774717A/en not_active IP Right Cessation
- 1971-10-30 JP JP8671171A patent/JPS5510576B1/ja active Pending
- 1971-11-01 AU AU35209/71A patent/AU473909B2/en not_active Expired
- 1971-11-02 AT AT09439/71A patent/AT312166B/en not_active IP Right Cessation
-
1974
- 1974-06-24 FI FI1919/74A patent/FI59789C/en active
- 1974-06-24 DK DK337274A patent/DK152119C/en not_active IP Right Cessation
- 1974-06-26 AU AU70520/74A patent/AU497158B2/en not_active Expired
- 1974-06-26 DE DE2430550A patent/DE2430550C2/en not_active Expired
- 1974-06-27 ES ES427715A patent/ES427715A2/en not_active Expired
- 1974-06-28 CA CA203,732A patent/CA1014552A/en not_active Expired
- 1974-06-28 ZA ZA00744181A patent/ZA744181B/en unknown
- 1974-06-28 GB GB2877374A patent/GB1463726A/en not_active Expired
- 1974-06-28 BE BE146061A patent/BE817063R/en active
- 1974-06-28 CH CH895274A patent/CH611875A5/en not_active IP Right Cessation
- 1974-06-28 IL IL45146A patent/IL45146A/en unknown
- 1974-06-28 FR FR7422640A patent/FR2282865A2/en active Granted
- 1974-06-28 AT AT540074A patent/AT332970B/en not_active IP Right Cessation
- 1974-07-01 SE SE7408685A patent/SE389333B/en not_active IP Right Cessation
- 1974-07-01 JP JP49075255A patent/JPS5745215B2/ja not_active Expired
- 1974-07-01 NL NL7408875A patent/NL7408875A/en not_active Application Discontinuation
-
1979
- 1979-11-15 HK HK790/79A patent/HK79079A/en unknown
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