ES424429A1 - 3-n-butyl-amino-4-phenoxy-5-sulphamoyl-benzoic acids and process for their manufacture - Google Patents

3-n-butyl-amino-4-phenoxy-5-sulphamoyl-benzoic acids and process for their manufacture

Info

Publication number
ES424429A1
ES424429A1 ES424429A ES424429A ES424429A1 ES 424429 A1 ES424429 A1 ES 424429A1 ES 424429 A ES424429 A ES 424429A ES 424429 A ES424429 A ES 424429A ES 424429 A1 ES424429 A1 ES 424429A1
Authority
ES
Spain
Prior art keywords
formula
phenoxy
alcohol
group
sulphamoyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES424429A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hoechst AG
Original Assignee
Hoechst AG
Farbwerke Hoechst AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19732314937 external-priority patent/DE2314937A1/en
Priority claimed from DE19732339714 external-priority patent/DE2339714A1/en
Application filed by Hoechst AG, Farbwerke Hoechst AG filed Critical Hoechst AG
Publication of ES424429A1 publication Critical patent/ES424429A1/en
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/18—Sulfonamides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof

Abstract

Procedure for the preparation of 3-n-butylamino-4-phenoxy-5-sulfamoylbenzoic acids of the formula I ** (See formula) ** wherein R1 means an alcohol group with 1 to 6 carbon atoms that may be branched or once unsaturated, or an aralkohyl group with up to 9 carbon atoms or a 2- (3- or 4-) pyridylmethyl group, characterized in that a 3-n-butylamino-4-phenoxy-5-sulfamoylbenzoic acid derivative of the formula II is reacted ** (See formula) ** with an alcohol of the formula R1OH if R2 represents CH2-O-CH3 and R represents hydrogen; with formaldehyde in the presence of an alcohol of the formula R1OH if R and R2 represent hydrogen, and hydrogenating a compound of the formula II in the presence of a palladium catalyst if R2 represents CH2-OR1 and R represents a benzyl group which may have one or plus alcohol or alkoxy groups, halogen atoms or nitro groups in the phenyl radical. (Machine-translation by Google Translate, not legally binding)
ES424429A 1973-03-26 1974-03-20 3-n-butyl-amino-4-phenoxy-5-sulphamoyl-benzoic acids and process for their manufacture Expired ES424429A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19732314937 DE2314937A1 (en) 1973-03-26 1973-03-26 3-Butylamino-4-phenoxy-5-sulphamoyl-benzoic acids - as diuretic and saluretic agents
DE19732339714 DE2339714A1 (en) 1973-08-06 1973-08-06 3-Butylamino-4-phenoxy-5-sulphamoyl-benzoic acids - as diuretic and saluretic agents

Publications (1)

Publication Number Publication Date
ES424429A1 true ES424429A1 (en) 1976-07-01

Family

ID=25764875

Family Applications (1)

Application Number Title Priority Date Filing Date
ES424429A Expired ES424429A1 (en) 1973-03-26 1974-03-20 3-n-butyl-amino-4-phenoxy-5-sulphamoyl-benzoic acids and process for their manufacture

Country Status (8)

Country Link
JP (1) JPS49126647A (en)
AT (1) AT331780B (en)
AU (1) AU6710074A (en)
ES (1) ES424429A1 (en)
FR (1) FR2223023B1 (en)
GB (1) GB1459677A (en)
IL (1) IL44476A0 (en)
NL (1) NL7403835A (en)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2010508300A (en) * 2006-10-26 2010-03-18 フライン、ギャリー・エー． Aquaporin modifiers and methods for their use for the treatment of edema and fluid balance abnormalities

Also Published As

Publication number Publication date
AU6710074A (en) 1975-09-25
AT331780B (en) 1976-08-25
ATA245174A (en) 1975-12-15
JPS49126647A (en) 1974-12-04
FR2223023A1 (en) 1974-10-25
GB1459677A (en) 1976-12-22
NL7403835A (en) 1974-09-30
IL44476A0 (en) 1974-06-30
FR2223023B1 (en) 1977-11-04

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