ES417006A1 - Procedimiento para la preparacion de 4-fenil-imidazolinas. - Google Patents
Procedimiento para la preparacion de 4-fenil-imidazolinas.Info
- Publication number
- ES417006A1 ES417006A1 ES417006A ES417006A ES417006A1 ES 417006 A1 ES417006 A1 ES 417006A1 ES 417006 A ES417006 A ES 417006A ES 417006 A ES417006 A ES 417006A ES 417006 A1 ES417006 A1 ES 417006A1
- Authority
- ES
- Spain
- Prior art keywords
- hydrogen
- ethyl
- alkyl
- carbon atoms
- piperazino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 150000003839 salts Chemical class 0.000 title abstract 3
- BHUSOIQBDQNPAZ-UHFFFAOYSA-N 5-phenyl-4,5-dihydro-1h-imidazol-2-amine Chemical class C1NC(N)=NC1C1=CC=CC=C1 BHUSOIQBDQNPAZ-UHFFFAOYSA-N 0.000 title 1
- -1 furfuryl Chemical group 0.000 abstract 7
- 239000001257 hydrogen Substances 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 6
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004432 carbon atom Chemical group C* 0.000 abstract 4
- 150000002431 hydrogen Chemical class 0.000 abstract 3
- GAWIXWVDTYZWAW-UHFFFAOYSA-N C[CH]O Chemical group C[CH]O GAWIXWVDTYZWAW-UHFFFAOYSA-N 0.000 abstract 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000000623 heterocyclic group Chemical group 0.000 abstract 2
- 229910052757 nitrogen Inorganic materials 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- 208000001953 Hypotension Diseases 0.000 abstract 1
- MZVQCMJNVPIDEA-UHFFFAOYSA-N [CH2]CN(CC)CC Chemical group [CH2]CN(CC)CC MZVQCMJNVPIDEA-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002947 alkylene group Chemical group 0.000 abstract 1
- 230000003288 anthiarrhythmic effect Effects 0.000 abstract 1
- 239000003416 antiarrhythmic agent Substances 0.000 abstract 1
- 229940127218 antiplatelet drug Drugs 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 1
- 208000021822 hypotensive Diseases 0.000 abstract 1
- 230000001077 hypotensive effect Effects 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 231100000252 nontoxic Toxicity 0.000 abstract 1
- 230000003000 nontoxic effect Effects 0.000 abstract 1
- 239000000106 platelet aggregation inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/46—Nitrogen atoms not forming part of a nitro radical with only hydrogen atoms attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/48—Nitrogen atoms not forming part of a nitro radical with acyclic hydrocarbon or substituted acyclic hydrocarbon radicals, attached to said nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19722235314 DE2235314A1 (de) | 1972-07-19 | 1972-07-19 | Substituierte 4-phenyl-imidazoline, deren saeureadditionssalze und verfahren zu deren herstellung |
| DE19722235328 DE2235328A1 (de) | 1972-07-19 | 1972-07-19 | Substituierte 4-phenyl-imidazoline, deren saeureadditionssalze und verfahren zu deren herstellung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES417006A1 true ES417006A1 (es) | 1976-03-01 |
Family
ID=25763580
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES417006A Expired ES417006A1 (es) | 1972-07-19 | 1973-07-17 | Procedimiento para la preparacion de 4-fenil-imidazolinas. |
| ES430752A Expired ES430752A1 (es) | 1972-07-19 | 1974-10-07 | Procedimiento para la preparacion de 4-fenil-imidazolinas. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES430752A Expired ES430752A1 (es) | 1972-07-19 | 1974-10-07 | Procedimiento para la preparacion de 4-fenil-imidazolinas. |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US4080503A (OSRAM) |
| JP (1) | JPS4951279A (OSRAM) |
| ES (2) | ES417006A1 (OSRAM) |
| FR (1) | FR2192841B1 (OSRAM) |
| GB (1) | GB1444593A (OSRAM) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4195092A (en) * | 1977-12-27 | 1980-03-25 | Eli Lilly And Company | 2-(Substituted amino)-N-(3-substituted phenyl)-2-imidazoline-1-carbothioamides |
| US4288591A (en) * | 1979-02-06 | 1981-09-08 | A. H. Robins Company, Inc. | 4-Substituted 2-iminoimidazolidine compounds |
| US4288447A (en) * | 1979-02-06 | 1981-09-08 | A. H. Robins Company, Inc. | Antihyperglycemic 4-substituted 2-iminoimidazolidine compositions |
| US5258381A (en) * | 1984-03-19 | 1993-11-02 | The Rockefeller University | 2-substituted-2-imidazolines |
| US5633376A (en) * | 1990-12-28 | 1997-05-27 | Neurogen Corporation | Certain aminomethyl phenylimidazole derivatives; and 4-aryl substituted piperazinyl and piperidinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype ligands |
| US5646279A (en) * | 1990-12-28 | 1997-07-08 | Neurogen Corporation | Substituted 4-piperazinylmethyl 2-phenylimidazoles; dopamine receptor subtype specific ligands |
| US5681956A (en) * | 1990-12-28 | 1997-10-28 | Neurogen Corporation | 4-aryl substituted piperazinylmethyl phenylimidazole derivatives; a new class of dopamine receptor subtype specific ligands |
| US5712392A (en) * | 1990-12-28 | 1998-01-27 | Neurogen Corporation | Certain 4-piperidine- and piperazinoalkyl-2-phenyl imidazole derivatives; dopamine receptor subtype specific ligands |
| US6166205A (en) * | 1998-09-02 | 2000-12-26 | Neurogen Corporation | 2-Aryl-4-(1-[4-heteroaryl]piperazin-1-yl)methylimidazoles: dopamine . D.sub4 receptor subtype ligands |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1211341A (fr) * | 1955-12-19 | 1960-03-15 | A Wander Dr | Procédé pour la préparation de 2-amino-imidazolines |
| BE759125A (fr) * | 1969-11-19 | 1971-05-18 | Boehringer Sohn Ingelheim | Nouvelles n-allyl-2-arylamino-imidazolines-(2) substituees et procedes pour les fabriquer |
-
1973
- 1973-07-16 US US05/379,750 patent/US4080503A/en not_active Expired - Lifetime
- 1973-07-17 ES ES417006A patent/ES417006A1/es not_active Expired
- 1973-07-18 JP JP48082434A patent/JPS4951279A/ja active Pending
- 1973-07-19 GB GB3443673A patent/GB1444593A/en not_active Expired
- 1973-07-19 FR FR7326601A patent/FR2192841B1/fr not_active Expired
-
1974
- 1974-10-07 ES ES430752A patent/ES430752A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| FR2192841B1 (OSRAM) | 1977-04-15 |
| US4080503A (en) | 1978-03-21 |
| ES430752A1 (es) | 1976-10-16 |
| FR2192841A1 (OSRAM) | 1974-02-15 |
| GB1444593A (en) | 1976-08-04 |
| JPS4951279A (OSRAM) | 1974-05-18 |
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