ES413279A1 - Pyridine derivatives having hypoglycaemic activity - Google Patents
Pyridine derivatives having hypoglycaemic activityInfo
- Publication number
- ES413279A1 ES413279A1 ES413279A ES413279A ES413279A1 ES 413279 A1 ES413279 A1 ES 413279A1 ES 413279 A ES413279 A ES 413279A ES 413279 A ES413279 A ES 413279A ES 413279 A1 ES413279 A1 ES 413279A1
- Authority
- ES
- Spain
- Prior art keywords
- group
- formula
- alk
- carboxylic acid
- pyridyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
- C07D213/30—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
A procedure for the preparation of biologically active compounds in the treatment of hypoglycemia of the formula (I) or (II) **(See formula)** in whose formulas "Py" represents a substituted or unsubstituted, 2-, 3- or 4-pyridyl N-oxidized or quaternized pyridyl group; "A" represents a group of the formula (IIIA), (IIIB) or (IIIC) **(See formula)** in which "ALK" represents a straight or branched chain alkylene group with 1 to 6 carbon atoms; R1 represents a carboxylic acid group, a group that is converted in the human body to a carboxylic acid group or an acyl group; R2, R3 and R4 each represent hydrogen, a carboxylic acid group, a group that converts in the human body to a carboxylic acid group, an acyl group, a hydroxy group, an alkoxy group, an aralkoxy group, an aryloxy group, a halogen group or an amino group, except that it is not methyl, cyano or methoxycarbonyl when "Py" is 2-pyridyl or 5-ethylpyrid-2-yl and A is - [O-CH2] - and R2, R3 and R4 are hydrogen or halogen; or one of its pharmaceutically acceptable salts, characterized by condensing a compound of the formula (IV) with a compound of the formula (V) (IV) B - (Alk) nOH HO- (Alk) m-Py (V) in which n and m are 0 or 1, provided that n + m is not zero and "ALK" and "Py" have the meaning indicated in relation to formula (I) or (II) and the symbol B represents a group of the formula (IA) or (IIA) **(See formula)** in which R1, R2, R3 and R4 have the indicated meaning in relation to formula (I) or (II). (Machine-translation by Google Translate, not legally binding)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB1528072A GB1437781A (en) | 1972-04-04 | 1972-04-04 | Pyridine derivatives having hypoglycaemic activity |
Publications (1)
Publication Number | Publication Date |
---|---|
ES413279A1 true ES413279A1 (en) | 1976-01-01 |
Family
ID=10056262
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES413279A Expired ES413279A1 (en) | 1972-04-04 | 1973-04-03 | Pyridine derivatives having hypoglycaemic activity |
Country Status (20)
Country | Link |
---|---|
JP (1) | JPS49100091A (en) |
AR (1) | AR208269A1 (en) |
AT (1) | AT339301B (en) |
BE (1) | BE797715A (en) |
BG (1) | BG20352A3 (en) |
CA (1) | CA999868A (en) |
CH (1) | CH576961A5 (en) |
CS (1) | CS183689B2 (en) |
DD (1) | DD106834A5 (en) |
DE (1) | DE2316881A1 (en) |
ES (1) | ES413279A1 (en) |
FR (1) | FR2182933B1 (en) |
GB (1) | GB1437781A (en) |
HU (1) | HU165731B (en) |
IE (1) | IE37412B1 (en) |
IL (1) | IL41825A (en) |
NL (1) | NL7304610A (en) |
PL (1) | PL96043B1 (en) |
RO (2) | RO63069A (en) |
ZA (1) | ZA731853B (en) |
Families Citing this family (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4409227A (en) | 1979-08-09 | 1983-10-11 | The Dow Chemical Co. | 4-(((Heterocyclo)thio)methyl)benzoic acids, esters and amides and their pharmaceutical use |
DE69204231T2 (en) * | 1991-07-03 | 1996-01-25 | Unilever Nv | Chocolate filling containing an anti-greasy additive. |
ATE121271T1 (en) * | 1991-07-03 | 1995-05-15 | Unilever Nv | IMPROVED CHOCOLATE COMPOSITION. |
US5453433A (en) * | 1994-05-13 | 1995-09-26 | Sterling Winthrop Inc. | Thiadiazoles and antipicornaviral compositions |
JP2000509373A (en) * | 1996-04-19 | 2000-07-25 | ノボ ノルディスク アクティーゼルスカブ | Modulators of molecules with phosphotyrosine recognition units |
US6043247A (en) * | 1996-04-19 | 2000-03-28 | Novo Nordisk A/S | Modulators of molecules with phosphotyrosine recognition units |
US6329372B1 (en) | 1998-01-27 | 2001-12-11 | Celltech Therapeutics Limited | Phenylalanine derivatives |
ATE273273T1 (en) | 1998-02-26 | 2004-08-15 | Celltech Therapeutics Ltd | PHENYLALANINE DERIVATIVES AS INHIBITORS OF ALPHA4 INTEGRINS |
GB9805655D0 (en) | 1998-03-16 | 1998-05-13 | Celltech Therapeutics Ltd | Chemical compounds |
US6521626B1 (en) | 1998-03-24 | 2003-02-18 | Celltech R&D Limited | Thiocarboxamide derivatives |
GB9811159D0 (en) | 1998-05-22 | 1998-07-22 | Celltech Therapeutics Ltd | Chemical compounds |
GB9811969D0 (en) * | 1998-06-03 | 1998-07-29 | Celltech Therapeutics Ltd | Chemical compounds |
GB9812088D0 (en) | 1998-06-05 | 1998-08-05 | Celltech Therapeutics Ltd | Chemical compounds |
GB9814414D0 (en) * | 1998-07-03 | 1998-09-02 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821061D0 (en) | 1998-09-28 | 1998-11-18 | Celltech Therapeutics Ltd | Chemical compounds |
GB9821222D0 (en) | 1998-09-30 | 1998-11-25 | Celltech Therapeutics Ltd | Chemical compounds |
GB9825652D0 (en) | 1998-11-23 | 1999-01-13 | Celltech Therapeutics Ltd | Chemical compounds |
GB9826174D0 (en) | 1998-11-30 | 1999-01-20 | Celltech Therapeutics Ltd | Chemical compounds |
US6518283B1 (en) | 1999-05-28 | 2003-02-11 | Celltech R&D Limited | Squaric acid derivatives |
US6534513B1 (en) | 1999-09-29 | 2003-03-18 | Celltech R&D Limited | Phenylalkanoic acid derivatives |
US6455539B2 (en) | 1999-12-23 | 2002-09-24 | Celltech R&D Limited | Squaric acid derivates |
EP1332132B1 (en) | 2000-04-17 | 2007-10-10 | UCB Pharma, S.A. | Enamine derivatives as cell adhesion molecules |
US6545013B2 (en) | 2000-05-30 | 2003-04-08 | Celltech R&D Limited | 2,7-naphthyridine derivatives |
US6403608B1 (en) | 2000-05-30 | 2002-06-11 | Celltech R&D, Ltd. | 3-Substituted isoquinolin-1-yl derivatives |
AU2001267753A1 (en) | 2000-07-07 | 2002-01-21 | Celltech R And D Limited | Squaric acid derivatives containing a bicyclic heteroaromatic ring as integrin antagonists |
AU2001275724A1 (en) | 2000-08-02 | 2002-02-13 | Celltech R&D Limited | 3-substituted isoquinolin-1-yl derivatives |
KR101009472B1 (en) * | 2001-06-12 | 2011-01-19 | 웰스테트 테라퓨틱스 코포레이션 | Compounds for the Treatment of Metabolic Disorders |
GB0405033D0 (en) * | 2004-03-05 | 2004-04-07 | Karobio Ab | Novel pharmaceutical compositions |
TWI490214B (en) * | 2008-05-30 | 2015-07-01 | 艾德克 上野股份有限公司 | Benzene or thiophene derivative and use thereof as vap-1 inhibitor |
EP3019034B1 (en) | 2013-07-01 | 2018-10-31 | Givaudan SA | Organic compounds |
WO2016167153A1 (en) * | 2015-04-15 | 2016-10-20 | 長谷川香料株式会社 | Flavor modulator having pyridine derivative or salt thereof as active ingredient |
WO2017174879A1 (en) * | 2016-04-06 | 2017-10-12 | University Of Oulu | Compounds for use in the treatment of cancer |
-
1972
- 1972-04-04 GB GB1528072A patent/GB1437781A/en not_active Expired
-
1973
- 1973-01-01 AR AR247376A patent/AR208269A1/en active
- 1973-03-15 IE IE426/73A patent/IE37412B1/en unknown
- 1973-03-16 ZA ZA731853A patent/ZA731853B/en unknown
- 1973-03-19 IL IL41825A patent/IL41825A/en unknown
- 1973-03-30 HU HURO717A patent/HU165731B/hu unknown
- 1973-04-02 AT AT286773A patent/AT339301B/en not_active IP Right Cessation
- 1973-04-03 BE BE129595A patent/BE797715A/en unknown
- 1973-04-03 ES ES413279A patent/ES413279A1/en not_active Expired
- 1973-04-03 NL NL7304610A patent/NL7304610A/xx not_active Application Discontinuation
- 1973-04-03 CA CA167,818A patent/CA999868A/en not_active Expired
- 1973-04-03 RO RO7300083382A patent/RO63069A/en unknown
- 1973-04-03 RO RO7300074369A patent/RO62274A/en unknown
- 1973-04-03 JP JP48038610A patent/JPS49100091A/ja active Pending
- 1973-04-03 CS CS7300002387A patent/CS183689B2/en unknown
- 1973-04-04 DE DE2316881A patent/DE2316881A1/en active Pending
- 1973-04-04 CH CH482673A patent/CH576961A5/xx not_active IP Right Cessation
- 1973-04-04 PL PL1973161704A patent/PL96043B1/en unknown
- 1973-04-04 BG BG23170A patent/BG20352A3/xx unknown
- 1973-04-04 FR FR7312133A patent/FR2182933B1/fr not_active Expired
- 1973-04-04 DD DD169942A patent/DD106834A5/xx unknown
Also Published As
Publication number | Publication date |
---|---|
DE2316881A1 (en) | 1973-10-11 |
FR2182933A1 (en) | 1973-12-14 |
CS183689B2 (en) | 1978-07-31 |
IE37412B1 (en) | 1977-07-20 |
NL7304610A (en) | 1973-10-08 |
BG20352A3 (en) | 1975-11-05 |
GB1437781A (en) | 1976-06-03 |
RO63069A (en) | 1978-08-15 |
HU165731B (en) | 1974-10-28 |
IE37412L (en) | 1973-10-04 |
AR208269A1 (en) | 1976-12-20 |
DD106834A5 (en) | 1974-07-05 |
IL41825A0 (en) | 1973-05-31 |
ATA286773A (en) | 1977-02-15 |
PL96043B1 (en) | 1977-11-30 |
JPS49100091A (en) | 1974-09-20 |
IL41825A (en) | 1977-03-31 |
BE797715A (en) | 1973-10-03 |
ZA731853B (en) | 1974-01-30 |
CA999868A (en) | 1976-11-16 |
AT339301B (en) | 1977-10-10 |
RO62274A (en) | 1977-12-15 |
FR2182933B1 (en) | 1976-05-14 |
CH576961A5 (en) | 1976-06-30 |
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