ES398499A1 - Un procedimiento de preparacion de la vincamina natural. - Google Patents
Un procedimiento de preparacion de la vincamina natural.Info
- Publication number
- ES398499A1 ES398499A1 ES398499A ES398499A ES398499A1 ES 398499 A1 ES398499 A1 ES 398499A1 ES 398499 A ES398499 A ES 398499A ES 398499 A ES398499 A ES 398499A ES 398499 A1 ES398499 A1 ES 398499A1
- Authority
- ES
- Spain
- Prior art keywords
- vincamine
- stage
- treated
- see formula
- translation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- RXPRRQLKFXBCSJ-GIVPXCGWSA-N vincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-GIVPXCGWSA-N 0.000 title abstract 8
- RXPRRQLKFXBCSJ-UHFFFAOYSA-N dl-Vincamin Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)CC(O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-UHFFFAOYSA-N 0.000 title abstract 6
- 229960002726 vincamine Drugs 0.000 title abstract 4
- 238000000034 method Methods 0.000 title abstract 2
- RXPRRQLKFXBCSJ-HLAWJBBLSA-N 16-epivincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C[C@@](O)(C(=O)OC)N5C2=C1 RXPRRQLKFXBCSJ-HLAWJBBLSA-N 0.000 abstract 3
- OZDNDGXASTWERN-CTNGQTDRSA-N Apovincamine Chemical compound C1=CC=C2C(CCN3CCC4)=C5[C@@H]3[C@]4(CC)C=C(C(=O)OC)N5C2=C1 OZDNDGXASTWERN-CTNGQTDRSA-N 0.000 abstract 3
- 229950006936 apovincamine Drugs 0.000 abstract 2
- OZDNDGXASTWERN-UHFFFAOYSA-N apovincamine Natural products C1=CC=C2C(CCN3CCC4)=C5C3C4(CC)C=C(C(=O)OC)N5C2=C1 OZDNDGXASTWERN-UHFFFAOYSA-N 0.000 abstract 2
- 238000002425 crystallisation Methods 0.000 abstract 2
- 230000008025 crystallization Effects 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 150000002978 peroxides Chemical class 0.000 abstract 2
- RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 abstract 2
- JSLDLCGKZDUQSH-RTBUJCADSA-N 19-epivindolinine Natural products O=C(OC)[C@H]1[C@@]23[C@H](C)[C@]4([C@@H]5N(CC=C4)CC[C@]25c2c(N3)cccc2)C1 JSLDLCGKZDUQSH-RTBUJCADSA-N 0.000 abstract 1
- 125000000815 N-oxide group Chemical group 0.000 abstract 1
- KILNDJCLJBOWAN-UHFFFAOYSA-N Tabersonine Natural products CCC12CC(=C3N(C)c4cc(OC)ccc4C35CCN(CC=C1)C25)C(=O)OC KILNDJCLJBOWAN-UHFFFAOYSA-N 0.000 abstract 1
- 241001246889 Voacanga Species 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 238000009903 catalytic hydrogenation reaction Methods 0.000 abstract 1
- 239000003638 chemical reducing agent Substances 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000008707 rearrangement Effects 0.000 abstract 1
- FNGGIPWAZSFKCN-ACRUOGEOSA-N tabersonine Chemical compound N1C2=CC=CC=C2[C@]2([C@H]34)C1=C(C(=O)OC)C[C@]3(CC)C=CCN4CC2 FNGGIPWAZSFKCN-ACRUOGEOSA-N 0.000 abstract 1
- FNGGIPWAZSFKCN-UHFFFAOYSA-N xi-tabersonine Natural products N1C2=CC=CC=C2C2(C34)C1=C(C(=O)OC)CC3(CC)C=CCN4CC2 FNGGIPWAZSFKCN-UHFFFAOYSA-N 0.000 abstract 1
Landscapes
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| BE761628A BE761628A (fr) | 1971-01-15 | 1971-01-15 | Procede de preparation de la vincamine naturelle a partir de latabersonine et derives indoliques nouveaux. |
| BE763730A BE763730R (fr) | 1971-01-15 | 1971-03-03 | Procede de preparation de la vincamine naturelle a partir de latabersonine et derives indoliques |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES398499A1 true ES398499A1 (es) | 1975-09-16 |
Family
ID=25656882
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES398499A Expired ES398499A1 (es) | 1971-01-15 | 1971-12-30 | Un procedimiento de preparacion de la vincamina natural. |
| ES425906A Expired ES425906A1 (es) | 1971-01-15 | 1974-05-02 | Un procedimiento de preparacion de derivados de oxidacion de la (-) vincadiformina y de ia (-) tabersonina. |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES425906A Expired ES425906A1 (es) | 1971-01-15 | 1974-05-02 | Un procedimiento de preparacion de derivados de oxidacion de la (-) vincadiformina y de ia (-) tabersonina. |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JPS5133120B1 (enExample) |
| DK (1) | DK143562C (enExample) |
| ES (2) | ES398499A1 (enExample) |
| IT (1) | IT1043893B (enExample) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS6062078U (ja) * | 1983-10-03 | 1985-04-30 | 本州製紙株式会社 | 害虫忌避容器 |
-
1971
- 1971-12-30 ES ES398499A patent/ES398499A1/es not_active Expired
-
1972
- 1972-01-13 DK DK16772A patent/DK143562C/da not_active IP Right Cessation
- 1972-01-14 IT IT6712272A patent/IT1043893B/it active
- 1972-01-17 JP JP47006857A patent/JPS5133120B1/ja active Pending
-
1974
- 1974-05-02 ES ES425906A patent/ES425906A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| DK143562C (da) | 1982-02-01 |
| JPS5133120B1 (enExample) | 1976-09-17 |
| IT1043893B (it) | 1980-02-29 |
| ES425906A1 (es) | 1976-09-01 |
| DK143562B (da) | 1981-09-07 |
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